Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10795
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger protein 268
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZNF268
Synonyms (NCBI Gene) Gene synonyms aliases
HZF3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT271119 hsa-miR-217 PAR-CLIP 20371350
MIRT271126 hsa-miR-6807-3p PAR-CLIP 20371350
MIRT271120 hsa-miR-296-3p PAR-CLIP 20371350
MIRT271125 hsa-miR-4729 PAR-CLIP 20371350
MIRT510418 hsa-miR-342-3p PAR-CLIP 20371350
Transcription factors
Transcription factor Regulation Reference
GATA1 Repression 22235304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 12822888
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 Function DNA binding NAS 11311945
GO:0003700 Function DNA-binding transcription factor activity NAS 11311945
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604753 13061 ENSG00000090612
Protein
UniProt ID Q14587
Protein name Zinc finger protein 268 (Zinc finger protein HZF3)
Protein function [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; [Isoform 2]: Contributes to cervical carcinogenesis in
PDB 2EL4 , 2EL5 , 2EL6 , 2EM1 , 2EMV , 2EMW , 2EMX , 2EMY , 2EN0 , 2EN6 , 2EN7 , 2EOF , 2EOG , 2EOI , 2EOJ , 2EOK , 2EOL , 2EOP , 2EPV , 2EPW , 2EPY , 2YTF , 2YTQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 80 121 KRAB box Family
PF00096 zf-C2H2 304 326 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 332 354 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 360 382 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 388 410 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 416 438 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 444 466 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 500 522 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 528 550 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 556 578 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 584 606 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 612 634 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 640 662 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 668 690 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 696 718 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 724 746 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 752 774 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 780 802 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 808 830 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 864 886 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 892 914 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in b
Sequence
MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEK
VLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSL
G
YQHTKPDIIFKLEQGEELCMVQAQVPNQTCPNTVWKIDDLMDWHQENKDKLGSTAKSFE
CTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSDYARNNPNGFQVHGKSFFHSKHE
QTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAE
EKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPY
ECCECGKVFSRKDQLVSHQKTH
SGQKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNE
CQKAFNTKSNLMVHQRTH
TGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKG
FSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFK
SQLIIHQRIH
TGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLI
IHQRTH
TGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKG
VH
TGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTG
EKPHECRECGKSFSFNSQLIVHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEKPY
GCSECGKAFSSKSYLIIHMRTH
SGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQ
CEKSFSGKLRLLVHQRMHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKT
FSQKSILSAHQRTH
TGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH
Sequence length 947
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Coronary artery disease Coronary artery disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Inhibit 35735115
Leukemia Associate 18375384
Leukemia Lymphoma Adult T Cell Associate 18375384
Neoplasms Inhibit 35735115