Gene Gene information from NCBI Gene database.
Entrez ID 10795
Gene name Zinc finger protein 268
Gene symbol ZNF268
Synonyms (NCBI Gene)
HZF3
Chromosome 12
Chromosome location 12q24.33
miRNA miRNA information provided by mirtarbase database.
402
miRTarBase ID miRNA Experiments Reference
MIRT271119 hsa-miR-217 PAR-CLIP 20371350
MIRT271126 hsa-miR-6807-3p PAR-CLIP 20371350
MIRT271120 hsa-miR-296-3p PAR-CLIP 20371350
MIRT271125 hsa-miR-4729 PAR-CLIP 20371350
MIRT510418 hsa-miR-342-3p PAR-CLIP 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
GATA1 Repression 22235304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 12822888
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001934 Process Positive regulation of protein phosphorylation IDA 23091055
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding NAS 11311945
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604753 13061 ENSG00000090612
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14587
Protein name Zinc finger protein 268 (Zinc finger protein HZF3)
Protein function [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; [Isoform 2]: Contributes to cervical carcinogenesis in
PDB 2EL4 , 2EL5 , 2EL6 , 2EM1 , 2EMV , 2EMW , 2EMX , 2EMY , 2EN0 , 2EN6 , 2EN7 , 2EOF , 2EOG , 2EOI , 2EOJ , 2EOK , 2EOL , 2EOP , 2EPV , 2EPW , 2EPY , 2YTF , 2YTQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 80 121 KRAB box Family
PF00096 zf-C2H2 304 326 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 332 354 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 360 382 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 388 410 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 416 438 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 444 466 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 500 522 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 528 550 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 556 578 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 584 606 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 612 634 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 640 662 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 668 690 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 696 718 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 724 746 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 752 774 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 780 802 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 808 830 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 864 886 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 892 914 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in b
Sequence
MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEK
VLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSL
G
YQHTKPDIIFKLEQGEELCMVQAQVPNQTCPNTVWKIDDLMDWHQENKDKLGSTAKSFE
CTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSDYARNNPNGFQVHGKSFFHSKHE
QTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAE
EKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPY
ECCECGKVFSRKDQLVSHQKTH
SGQKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNE
CQKAFNTKSNLMVHQRTH
TGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKG
FSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFK
SQLIIHQRIH
TGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLI
IHQRTH
TGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKG
VH
TGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTG
EKPHECRECGKSFSFNSQLIVHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEKPY
GCSECGKAFSSKSYLIIHMRTH
SGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQ
CEKSFSGKLRLLVHQRMHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKT
FSQKSILSAHQRTH
TGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH
Sequence length 947
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
EBV-positive nodal T- and NK-cell lymphoma Likely benign rs1956816023 RCV004558064
Melanoma Benign rs36127550 RCV005923559
Thyroid cancer, nonmedullary, 1 Benign rs36127550 RCV005923558
Uterine carcinosarcoma Benign rs36127550 RCV005923557
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Renal Cell Inhibit 35735115
Leukemia Associate 18375384
Leukemia Lymphoma Adult T Cell Associate 18375384
Neoplasms Inhibit 35735115