UniProt ID |
Q14587
|
Protein name |
Zinc finger protein 268 (Zinc finger protein HZF3) |
Protein function |
[Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; [Isoform 2]: Contributes to cervical carcinogenesis in |
PDB |
2EL4
,
2EL5
,
2EL6
,
2EM1
,
2EMV
,
2EMW
,
2EMX
,
2EMY
,
2EN0
,
2EN6
,
2EN7
,
2EOF
,
2EOG
,
2EOI
,
2EOJ
,
2EOK
,
2EOL
,
2EOP
,
2EPV
,
2EPW
,
2EPY
,
2YTF
,
2YTQ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01352
|
KRAB |
80 → 121 |
KRAB box |
Family |
PF00096
|
zf-C2H2 |
304 → 326 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
332 → 354 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
360 → 382 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
388 → 410 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
416 → 438 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
444 → 466 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
500 → 522 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
528 → 550 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
556 → 578 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
584 → 606 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
612 → 634 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
640 → 662 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
668 → 690 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
696 → 718 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
724 → 746 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
752 → 774 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
780 → 802 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
808 → 830 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
864 → 886 |
Zinc finger, C2H2 type |
Domain |
PF00096
|
zf-C2H2 |
892 → 914 |
Zinc finger, C2H2 type |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in b |
Sequence |
|
Sequence length |
947 |
Interactions |
View interactions
|