POP4 (POP4 ribonuclease P/MRP subunit)

Gene

• Entrez ID: 10775
• Gene name: POP4 ribonuclease P/MRP subunit
• Gene symbol: POP4
• Synonyms (NCBI Gene): RPP29
• Chromosome: 19
• Chromosome location: 19q12
• Summary: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029286	hsa-miR-26b-5p	Microarray	19088304
MIRT049425	hsa-miR-92a-3p	CLASH	23622248
MIRT045865	hsa-miR-128-3p	CLASH	23622248
MIRT650776	hsa-miR-4301	HITS-CLIP	23824327
MIRT650775	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650774	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT650773	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT650772	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT650771	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT650770	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT650769	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT650776	hsa-miR-4301	HITS-CLIP	23824327
MIRT650775	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650774	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT650773	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT650772	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT650771	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT650770	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT650769	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT442653	hsa-miR-1264	PAR-CLIP	22100165
MIRT442651	hsa-miR-4499	PAR-CLIP	22100165
MIRT442652	hsa-miR-1178-5p	PAR-CLIP	22100165
MIRT442650	hsa-miR-4494	PAR-CLIP	22100165
MIRT442649	hsa-miR-499b-5p	PAR-CLIP	22100165
MIRT442648	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT442647	hsa-miR-4480	PAR-CLIP	22100165
MIRT442646	hsa-miR-6801-5p	PAR-CLIP	22100165
MIRT1250176	hsa-miR-1200	CLIP-seq
MIRT1250177	hsa-miR-1224-5p	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250179	hsa-miR-1238	CLIP-seq
MIRT1250180	hsa-miR-1245b-3p	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT1250182	hsa-miR-1262	CLIP-seq
MIRT1250183	hsa-miR-1273g	CLIP-seq
MIRT1250184	hsa-miR-1291	CLIP-seq
MIRT1250185	hsa-miR-1293	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT1250188	hsa-miR-15a	CLIP-seq
MIRT1250189	hsa-miR-15b	CLIP-seq
MIRT1250190	hsa-miR-16	CLIP-seq
MIRT1250191	hsa-miR-195	CLIP-seq
MIRT1250192	hsa-miR-214	CLIP-seq
MIRT1250193	hsa-miR-2861	CLIP-seq
MIRT1250194	hsa-miR-3064-5p	CLIP-seq
MIRT1250195	hsa-miR-3135b	CLIP-seq
MIRT1250196	hsa-miR-3140-5p	CLIP-seq
MIRT1250197	hsa-miR-3173-5p	CLIP-seq
MIRT1250198	hsa-miR-3176	CLIP-seq
MIRT1250199	hsa-miR-3190	CLIP-seq
MIRT1250200	hsa-miR-3202	CLIP-seq
MIRT1250201	hsa-miR-328	CLIP-seq
MIRT1250202	hsa-miR-3616-5p	CLIP-seq
MIRT1250203	hsa-miR-3619-5p	CLIP-seq
MIRT1250204	hsa-miR-3647-5p	CLIP-seq
MIRT1250205	hsa-miR-3650	CLIP-seq
MIRT1250206	hsa-miR-3652	CLIP-seq
MIRT1250207	hsa-miR-3689d	CLIP-seq
MIRT1250208	hsa-miR-3922-3p	CLIP-seq
MIRT1250209	hsa-miR-3942-3p	CLIP-seq
MIRT1250210	hsa-miR-424	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT1250212	hsa-miR-4291	CLIP-seq
MIRT1250213	hsa-miR-4299	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT1250215	hsa-miR-4310	CLIP-seq
MIRT1250216	hsa-miR-4430	CLIP-seq
MIRT1250217	hsa-miR-4456	CLIP-seq
MIRT1250218	hsa-miR-4483	CLIP-seq
MIRT1250219	hsa-miR-4505	CLIP-seq
MIRT1250220	hsa-miR-4512	CLIP-seq
MIRT1250221	hsa-miR-4533	CLIP-seq
MIRT1250222	hsa-miR-4670-3p	CLIP-seq
MIRT1250223	hsa-miR-4701-3p	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT1250227	hsa-miR-4751	CLIP-seq
MIRT1250228	hsa-miR-4795-5p	CLIP-seq
MIRT1250229	hsa-miR-497	CLIP-seq
MIRT1250230	hsa-miR-545	CLIP-seq
MIRT1250231	hsa-miR-548p	CLIP-seq
MIRT1250232	hsa-miR-548q	CLIP-seq
MIRT1250233	hsa-miR-573	CLIP-seq
MIRT1250234	hsa-miR-761	CLIP-seq
MIRT1250235	hsa-miR-892b	CLIP-seq
MIRT1250236	hsa-miR-922	CLIP-seq
MIRT1250193	hsa-miR-2861	CLIP-seq
MIRT1250200	hsa-miR-3202	CLIP-seq
MIRT1250220	hsa-miR-4512	CLIP-seq
MIRT1250221	hsa-miR-4533	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT2073868	hsa-miR-1275	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT2073869	hsa-miR-1343	CLIP-seq
MIRT2073870	hsa-miR-1910	CLIP-seq
MIRT2073871	hsa-miR-1976	CLIP-seq
MIRT2073872	hsa-miR-24	CLIP-seq
MIRT2073873	hsa-miR-3175	CLIP-seq
MIRT2073874	hsa-miR-3664-3p	CLIP-seq
MIRT2073875	hsa-miR-3682-5p	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT2073876	hsa-miR-4279	CLIP-seq
MIRT2073877	hsa-miR-4284	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT2073878	hsa-miR-4525	CLIP-seq
MIRT2073879	hsa-miR-455-3p	CLIP-seq
MIRT2073880	hsa-miR-4660	CLIP-seq
MIRT2073881	hsa-miR-4665-5p	CLIP-seq
MIRT2073882	hsa-miR-4691-5p	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT2073883	hsa-miR-4723-5p	CLIP-seq
MIRT2073884	hsa-miR-4773	CLIP-seq
MIRT2073885	hsa-miR-625	CLIP-seq
MIRT2073886	hsa-miR-637	CLIP-seq
MIRT2073887	hsa-miR-885-3p	CLIP-seq
MIRT1250177	hsa-miR-1224-5p	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250180	hsa-miR-1245b-3p	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT2300714	hsa-miR-1914	CLIP-seq
MIRT2300715	hsa-miR-2682	CLIP-seq
MIRT1250194	hsa-miR-3064-5p	CLIP-seq
MIRT2300716	hsa-miR-3120-5p	CLIP-seq
MIRT1250206	hsa-miR-3652	CLIP-seq
MIRT2300717	hsa-miR-3688-5p	CLIP-seq
MIRT2300718	hsa-miR-3714	CLIP-seq
MIRT2300719	hsa-miR-3942-5p	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT1250216	hsa-miR-4430	CLIP-seq
MIRT2300720	hsa-miR-4457	CLIP-seq
MIRT2300721	hsa-miR-4484	CLIP-seq
MIRT2300722	hsa-miR-449c	CLIP-seq
MIRT1250219	hsa-miR-4505	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT2300723	hsa-miR-4703-5p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT1250227	hsa-miR-4751	CLIP-seq
MIRT2300724	hsa-miR-548an	CLIP-seq
MIRT2392849	hsa-miR-103a	CLIP-seq
MIRT2392850	hsa-miR-107	CLIP-seq
MIRT1250177	hsa-miR-1224-5p	CLIP-seq
MIRT1250178	hsa-miR-1237	CLIP-seq
MIRT1250180	hsa-miR-1245b-3p	CLIP-seq
MIRT1250181	hsa-miR-1248	CLIP-seq
MIRT1250186	hsa-miR-133a	CLIP-seq
MIRT1250187	hsa-miR-133b	CLIP-seq
MIRT2300714	hsa-miR-1914	CLIP-seq
MIRT1250193	hsa-miR-2861	CLIP-seq
MIRT2300716	hsa-miR-3120-5p	CLIP-seq
MIRT1250200	hsa-miR-3202	CLIP-seq
MIRT1250206	hsa-miR-3652	CLIP-seq
MIRT2300717	hsa-miR-3688-5p	CLIP-seq
MIRT1250211	hsa-miR-4259	CLIP-seq
MIRT1250214	hsa-miR-4303	CLIP-seq
MIRT1250216	hsa-miR-4430	CLIP-seq
MIRT1250219	hsa-miR-4505	CLIP-seq
MIRT1250220	hsa-miR-4512	CLIP-seq
MIRT1250221	hsa-miR-4533	CLIP-seq
MIRT1250224	hsa-miR-4703-3p	CLIP-seq
MIRT1250225	hsa-miR-4715-5p	CLIP-seq
MIRT1250226	hsa-miR-4716-5p	CLIP-seq
MIRT1250227	hsa-miR-4751	CLIP-seq
MIRT2597556	hsa-miR-122	CLIP-seq
MIRT2597557	hsa-miR-1321	CLIP-seq
MIRT2597558	hsa-miR-145	CLIP-seq
MIRT1250188	hsa-miR-15a	CLIP-seq
MIRT1250189	hsa-miR-15b	CLIP-seq
MIRT1250190	hsa-miR-16	CLIP-seq
MIRT1250191	hsa-miR-195	CLIP-seq
MIRT2597559	hsa-miR-198	CLIP-seq
MIRT1250192	hsa-miR-214	CLIP-seq
MIRT2597560	hsa-miR-2909	CLIP-seq
MIRT2597561	hsa-miR-3138	CLIP-seq
MIRT2597562	hsa-miR-3148	CLIP-seq
MIRT2597563	hsa-miR-3162-5p	CLIP-seq
MIRT2597564	hsa-miR-345	CLIP-seq
MIRT1250203	hsa-miR-3619-5p	CLIP-seq
MIRT2597565	hsa-miR-3646	CLIP-seq
MIRT2597566	hsa-miR-3647-3p	CLIP-seq
MIRT2597567	hsa-miR-3662	CLIP-seq
MIRT2597568	hsa-miR-377	CLIP-seq
MIRT2597569	hsa-miR-3909	CLIP-seq
MIRT1250210	hsa-miR-424	CLIP-seq
MIRT1250212	hsa-miR-4291	CLIP-seq
MIRT2597570	hsa-miR-4311	CLIP-seq
MIRT2597571	hsa-miR-4328	CLIP-seq
MIRT2597572	hsa-miR-4640-5p	CLIP-seq
MIRT2597573	hsa-miR-4643	CLIP-seq
MIRT2597574	hsa-miR-4698	CLIP-seq
MIRT2597575	hsa-miR-4717-3p	CLIP-seq
MIRT2597576	hsa-miR-4726-5p	CLIP-seq
MIRT2597577	hsa-miR-4739	CLIP-seq
MIRT2597578	hsa-miR-4756-5p	CLIP-seq
MIRT2597579	hsa-miR-488	CLIP-seq
MIRT1250229	hsa-miR-497	CLIP-seq
MIRT2597580	hsa-miR-499a-5p	CLIP-seq
MIRT2597581	hsa-miR-539	CLIP-seq
MIRT1250230	hsa-miR-545	CLIP-seq
MIRT2597582	hsa-miR-548c-3p	CLIP-seq
MIRT2597583	hsa-miR-548l	CLIP-seq
MIRT2597584	hsa-miR-548n	CLIP-seq
MIRT1250231	hsa-miR-548p	CLIP-seq
MIRT2597585	hsa-miR-642b	CLIP-seq
MIRT1250234	hsa-miR-761	CLIP-seq
MIRT1250236	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000172	Component	Ribonuclease MRP complex	IBA
GO:0000172	Component	Ribonuclease MRP complex	IEA
GO:0000172	Component	Ribonuclease MRP complex	TAS	10352175
GO:0001682	Process	TRNA 5'-leader removal	IDA	16723659, 30454648
GO:0001682	Process	TRNA 5'-leader removal	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004526	Function	Ribonuclease P activity	IDA	30454648
GO:0004526	Function	Ribonuclease P activity	IEA
GO:0005515	Function	Protein binding	IPI	15096576, 28514442, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	10444065
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IBA
GO:0006396	Process	RNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0030677	Component	Ribonuclease P complex	IBA
GO:0030677	Component	Ribonuclease P complex	IEA
GO:0030681	Component	Multimeric ribonuclease P complex	IDA	16723659, 30454648
GO:0033204	Function	Ribonuclease P RNA binding	IBA
GO:0033204	Function	Ribonuclease P RNA binding	IDA	16723659, 30454648
GO:0033204	Function	Ribonuclease P RNA binding	IEA

Other IDs

• MIM: 606114
• HGNC: 30081
• e!Ensembl: ENSG00000105171

Protein

• UniProt ID: O95707
• Protein name: Ribonuclease P protein subunit p29 (hPOP4)
• Protein function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
• PDB: 6AHR, 6AHU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01868	UPF0086	128 → 210	Domain of unknown function UPF0086	Family

• Sequence:

  MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEY
  FTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPD
  TQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKL
  NCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTIDL

• Sequence length: 220

Pathways

KEGG:

Ribosome biogenesis in eukaryotes

Reactome:

tRNA processing in the nucleus

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Nonpapillary renal cell carcinoma	Likely benign	rs773330218	RCV005929010
Thyroid cancer, nonmedullary, 1	Likely benign	rs773330218	RCV005929011

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	22433433
Cysts	Associate	33943042
Glioma	Associate	29921582
Neoplasms	Associate	22174824, 22433433, 39736017
Ovarian Neoplasms	Associate	22174824
Pancreatic Neoplasms	Associate	22377737
Polycystic Ovary Syndrome	Associate	32729067
Prostatic Neoplasms	Associate	19893039