Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10772
Gene name Gene Name - the full gene name approved by the HGNC.
Serine and arginine rich splicing factor 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SRSF10
Synonyms (NCBI Gene) Gene synonyms aliases
FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003994 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT003994 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT003994 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT003994 hsa-miR-29c-3p Reporter assay 18390668
MIRT048638 hsa-miR-99a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000244 Process Spliceosomal tri-snRNP complex assembly NAS 11684676
GO:0000375 Process RNA splicing, via transesterification reactions IDA 9774382
GO:0000375 Process RNA splicing, via transesterification reactions IEA
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IBA
GO:0000398 Process MRNA splicing, via spliceosome IDA 9774382
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605221 16713 ENSG00000188529
Protein
UniProt ID O75494
Protein name Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-a
Protein function Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Requ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 12 82 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:11891055}.
Sequence
MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED
VRDAEDALHNLDRKWICGRQIE
IQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSR
SRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSR
SRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSR
SQSRSRSKSRSRSWTSPKSSGH
Sequence length 262
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Spliceosome   mRNA Splicing - Major Pathway
<