Gene Gene information from NCBI Gene database.
Entrez ID 10768
Gene name Adenosylhomocysteinase like 1
Gene symbol AHCYL1
Synonyms (NCBI Gene)
DCALIRBITPPP1R78PRO0233XPVKONA
Chromosome 1
Chromosome location 1p13.3
Summary The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms h
miRNA miRNA information provided by mirtarbase database.
379
miRTarBase ID miRNA Experiments Reference
MIRT019871 hsa-miR-375 Microarray 20215506
MIRT031633 hsa-miR-16-5p Proteomics 18668040
MIRT052133 hsa-let-7b-5p CLASH 23622248
MIRT049333 hsa-miR-92a-3p CLASH 23622248
MIRT036279 hsa-miR-1229-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0004013 Function Adenosylhomocysteinase activity IBA
GO:0005515 Function Protein binding IPI 16769890, 16793548, 18829453, 19220705, 19224921, 20584908, 22190034, 25416956, 25910212, 26871637, 27995898, 28514442, 29513927, 31046837, 31515488, 32296183, 32814053, 33961781, 35156780, 36012204
GO:0005737 Component Cytoplasm IEA
GO:0005737 Component Cytoplasm ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607826 344 ENSG00000168710
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43865
Protein name S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)
Protein function Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphospha
PDB 3MTG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05221 AdoHcyase 104 241 S-adenosyl-L-homocysteine hydrolase Domain
PF05221 AdoHcyase 237 529 S-adenosyl-L-homocysteine hydrolase Domain
PF00670 AdoHcyase_NAD 289 450 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in dendritic cells. {ECO:0000269|PubMed:11904675}.
Sequence
MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQFADDMQEFTKFPTKTGR
RSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREI
EIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIY
STQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHW
VYKK
Y
PNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDG
LKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKL
NEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVR
SQVDHVIWPDGKRVVLLAEGRLLNLSCSTV
PTFVLSITATTQALALIELYNAPEGRYKQD
VYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYR
Y
Sequence length 530
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cysteine and methionine metabolism
One carbon pool by folate
Metabolic pathways
  Ion homeostasis