Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10768
Gene name Gene Name - the full gene name approved by the HGNC.
Adenosylhomocysteinase like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AHCYL1
Synonyms (NCBI Gene) Gene synonyms aliases
DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms h
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019871 hsa-miR-375 Microarray 20215506
MIRT031633 hsa-miR-16-5p Proteomics 18668040
MIRT052133 hsa-let-7b-5p CLASH 23622248
MIRT049333 hsa-miR-92a-3p CLASH 23622248
MIRT036279 hsa-miR-1229-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0004013 Function Adenosylhomocysteinase activity IBA 21873635
GO:0005515 Function Protein binding IPI 16769890, 16793548, 18829453, 19220705, 19224921, 20584908, 22190034, 25416956, 25910212, 26871637, 27995898, 28514442, 29513927, 31046837, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm ISS
GO:0005789 Component Endoplasmic reticulum membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607826 344 ENSG00000168710
Protein
UniProt ID O43865
Protein name S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)
Protein function Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphospha
PDB 3MTG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05221 AdoHcyase 104 241 S-adenosyl-L-homocysteine hydrolase Domain
PF05221 AdoHcyase 237 529 S-adenosyl-L-homocysteine hydrolase Domain
PF00670 AdoHcyase_NAD 289 450 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in dendritic cells. {ECO:0000269|PubMed:11904675}.
Sequence
MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQFADDMQEFTKFPTKTGR
RSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREI
EIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIY
STQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHW
VYKK
Y
PNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDG
LKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKL
NEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVR
SQVDHVIWPDGKRVVLLAEGRLLNLSCSTV
PTFVLSITATTQALALIELYNAPEGRYKQD
VYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYR
Y
Sequence length 530
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cysteine and methionine metabolism
One carbon pool by folate
Metabolic pathways
  Ion homeostasis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
26830138
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Cerebellar Diseases Associate 28698159
Colorectal Neoplasms Associate 38294692
Inflammation Associate 28809398
Melanoma Associate 38294692
Neoplasms Associate 38294692