Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
10767
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
HBS1 like translational GTPase |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
HBS1L |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
EF-1a, ERFS, HBS1, HSPC276, eRF3c |
Chromosome
Chromosome number
|
6 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
6q23.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitat |
UniProt ID |
Q9Y450
|
Protein name |
HBS1-like protein (EC 3.6.5.-) (ERFS) |
Protein function |
GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at th |
PDB |
5LZW
,
5LZX
,
5LZY
,
5LZZ
,
9G8M
,
9G8N
,
9G8O
,
9G8P
,
9G8R
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF08938
|
HBS1_N |
41 → 129 |
HBS1 N-terminus |
Domain |
PF00009
|
GTP_EFTU |
258 → 487 |
Elongation factor Tu GTP binding domain |
Domain |
PF03144
|
GTP_EFTU_D2 |
502 → 569 |
Elongation factor Tu domain 2 |
Domain |
PF03143
|
GTP_EFTU_D3 |
574 → 683 |
Elongation factor Tu C-terminal domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Detected in heart, brain, placenta, liver, muscle, kidney and pancreas. {ECO:0000269|PubMed:9872408}. |
Sequence |
|
Sequence length |
684 |
Interactions |
View interactions
|