Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10767
Gene name Gene Name - the full gene name approved by the HGNC.
HBS1 like translational GTPase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HBS1L
Synonyms (NCBI Gene) Gene synonyms aliases
EF-1a, ERFS, HBS1, HSPC276, eRF3c
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitat
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028343 hsa-miR-32-5p Sequencing 20371350
MIRT046986 hsa-miR-218-5p CLASH 23622248
MIRT046078 hsa-miR-125b-5p CLASH 23622248
MIRT038298 hsa-miR-130b-5p CLASH 23622248
MIRT693268 hsa-miR-5003-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003746 Function Translation elongation factor activity IEA
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 31515488, 32296183
GO:0005525 Function GTP binding IEA
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612450 4834 ENSG00000112339
Protein
UniProt ID Q9Y450
Protein name HBS1-like protein (EC 3.6.5.-) (ERFS)
Protein function GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at th
PDB 5LZW , 5LZX , 5LZY , 5LZZ , 9G8M , 9G8N , 9G8O , 9G8P , 9G8R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08938 HBS1_N 41 129 HBS1 N-terminus Domain
PF00009 GTP_EFTU 258 487 Elongation factor Tu GTP binding domain Domain
PF03144 GTP_EFTU_D2 502 569 Elongation factor Tu domain 2 Domain
PF03143 GTP_EFTU_D3 574 683 Elongation factor Tu C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in heart, brain, placenta, liver, muscle, kidney and pancreas. {ECO:0000269|PubMed:9872408}.
Sequence
Sequence length 684
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mRNA surveillance pathway
Legionellosis
  mRNA decay by 3' to 5' exoribonuclease
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Hypothyroidism Hypothyroidism GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Coronary artery disease Coronary artery disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anemia Hemolytic Associate 29879141
Anemia Sickle Cell Associate 18667698, 21068433, 24667352, 25084696, 25928412, 28280727, 28332727, 29879141, 38339995
beta Thalassemia Associate 19696200, 21068433, 21385855, 22271886, 26771086, 27009595, 28280727
Colorectal Neoplasms Associate 34537824
Disease Associate 33990643
Glycogen Storage Disease 0 Muscle Associate 26771086
Neoplasms Associate 25849990, 29047144
Ovarian Neoplasms Associate 32998774
Pain Associate 18667698
Spinocerebellar Ataxia 11 Associate 24667352, 25084696