Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10681
Gene name	G protein subunit beta 5
Gene symbol	GNB5
Synonyms (NCBI Gene)	GB5HG2EIDDCALADCILDMLS1LDMLS2gbeta5
Chromosome	15
Chromosome location	15q21.2
Summary	Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene enc

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SNP ID	Visualize variation	Clinical significance	Consequence
rs749597091	G>A,C,T	Pathogenic	Stop gained, non coding transcript variant, coding sequence variant, synonymous variant
rs761399728	G>A	Pathogenic, not-provided, likely-pathogenic	Missense variant, non coding transcript variant, genic upstream transcript variant, coding sequence variant
rs766004901	T>C	Pathogenic	Intron variant, genic upstream transcript variant
rs773902879	G>A	Pathogenic	Stop gained, coding sequence variant, non coding transcript variant
rs886041054	C>T	Pathogenic	Synonymous variant, genic upstream transcript variant, coding sequence variant, non coding transcript variant
rs886041055	C>A	Pathogenic	Genic upstream transcript variant, splice donor variant
rs1085307675	ATCTT>-	Pathogenic, not-provided	Genic upstream transcript variant, non coding transcript variant, coding sequence variant, frameshift variant
rs1261069673	A>-	Likely-pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant

406

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020117	hsa-miR-130b-3p	Sequencing	20371350
MIRT021914	hsa-miR-128-3p	Sequencing	20371350
MIRT025993	hsa-miR-148a-3p	Sequencing	20371350
MIRT028691	hsa-miR-27a-3p	Sequencing	20371350
MIRT028825	hsa-miR-26b-5p	Microarray	19088304
MIRT039346	hsa-miR-425-5p	CLASH	23622248
MIRT696205	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT696204	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT696203	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT696202	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT696201	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT696200	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT696199	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT696198	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT696197	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT696196	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT696195	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT696194	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT696193	hsa-miR-302e	HITS-CLIP	23313552
MIRT696192	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT696191	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT696190	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT696189	hsa-miR-520b	HITS-CLIP	23313552
MIRT696188	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT696187	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT696186	hsa-miR-520e	HITS-CLIP	23313552
MIRT696185	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT696184	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT696183	hsa-miR-520h	HITS-CLIP	23313552
MIRT696182	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT696181	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT696180	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT696179	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT696178	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT696177	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT696176	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT696175	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT696174	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT696173	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696172	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT649747	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT649746	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT649744	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT649745	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT649743	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT649742	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT649741	hsa-miR-1976	HITS-CLIP	23824327
MIRT649740	hsa-miR-4279	HITS-CLIP	23824327
MIRT519121	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT519120	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT696205	hsa-miR-106a-5p	HITS-CLIP	27418678
MIRT696204	hsa-miR-106b-5p	HITS-CLIP	27418678
MIRT696181	hsa-miR-1234-3p	HITS-CLIP	27418678
MIRT696179	hsa-miR-150-5p	HITS-CLIP	27418678
MIRT696203	hsa-miR-17-5p	HITS-CLIP	27418678
MIRT696182	hsa-miR-186-3p	HITS-CLIP	27418678
MIRT696202	hsa-miR-20a-5p	HITS-CLIP	27418678
MIRT696201	hsa-miR-20b-5p	HITS-CLIP	27418678
MIRT696197	hsa-miR-302a-3p	HITS-CLIP	27418678
MIRT696196	hsa-miR-302b-3p	HITS-CLIP	27418678
MIRT696195	hsa-miR-302c-3p	HITS-CLIP	27418678
MIRT696194	hsa-miR-302d-3p	HITS-CLIP	27418678
MIRT696193	hsa-miR-302e	HITS-CLIP	27418678
MIRT696192	hsa-miR-372-3p	HITS-CLIP	27418678
MIRT696191	hsa-miR-373-3p	HITS-CLIP	27418678
MIRT696176	hsa-miR-4707-3p	HITS-CLIP	27418678
MIRT696174	hsa-miR-4731-5p	HITS-CLIP	27418678
MIRT696172	hsa-miR-5089-5p	HITS-CLIP	27418678
MIRT696185	hsa-miR-512-3p	HITS-CLIP	27418678
MIRT696200	hsa-miR-519d-3p	HITS-CLIP	27418678
MIRT696190	hsa-miR-520a-3p	HITS-CLIP	27418678
MIRT696189	hsa-miR-520b	HITS-CLIP	27418678
MIRT696188	hsa-miR-520c-3p	HITS-CLIP	27418678
MIRT696187	hsa-miR-520d-3p	HITS-CLIP	27418678
MIRT696186	hsa-miR-520e	HITS-CLIP	27418678
MIRT696184	hsa-miR-520g-3p	HITS-CLIP	27418678
MIRT696183	hsa-miR-520h	HITS-CLIP	27418678
MIRT696199	hsa-miR-526b-3p	HITS-CLIP	27418678
MIRT696173	hsa-miR-5589-5p	HITS-CLIP	27418678
MIRT696178	hsa-miR-619-5p	HITS-CLIP	27418678
MIRT696177	hsa-miR-6506-5p	HITS-CLIP	27418678
MIRT696175	hsa-miR-6778-3p	HITS-CLIP	27418678
MIRT696180	hsa-miR-7107-5p	HITS-CLIP	27418678
MIRT696198	hsa-miR-93-5p	HITS-CLIP	27418678
MIRT696205	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT696204	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT696203	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT696202	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT696201	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT696200	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT696199	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT696198	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT696197	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT696196	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT696195	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT696194	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT696193	hsa-miR-302e	HITS-CLIP	23313552
MIRT696192	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT696191	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT696190	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT696189	hsa-miR-520b	HITS-CLIP	23313552
MIRT696188	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT696187	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT696186	hsa-miR-520e	HITS-CLIP	23313552
MIRT696185	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT696184	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT696183	hsa-miR-520h	HITS-CLIP	23313552
MIRT696182	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT696181	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT696180	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT696179	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT696178	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT696177	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT696176	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT696175	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT696174	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT696173	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696172	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT649747	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT649746	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT649744	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT649745	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT649743	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT649742	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT649741	hsa-miR-1976	HITS-CLIP	23824327
MIRT649740	hsa-miR-4279	HITS-CLIP	23824327
MIRT519121	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT519120	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT1024090	hsa-miR-106a	CLIP-seq
MIRT1024091	hsa-miR-106b	CLIP-seq
MIRT1024092	hsa-miR-128	CLIP-seq
MIRT1024093	hsa-miR-148a	CLIP-seq
MIRT1024094	hsa-miR-148b	CLIP-seq
MIRT1024095	hsa-miR-152	CLIP-seq
MIRT1024096	hsa-miR-17	CLIP-seq
MIRT1024097	hsa-miR-20a	CLIP-seq
MIRT1024098	hsa-miR-20b	CLIP-seq
MIRT1024099	hsa-miR-27a	CLIP-seq
MIRT1024100	hsa-miR-27b	CLIP-seq
MIRT1024101	hsa-miR-2861	CLIP-seq
MIRT1024102	hsa-miR-302a	CLIP-seq
MIRT1024103	hsa-miR-302b	CLIP-seq
MIRT1024104	hsa-miR-302c	CLIP-seq
MIRT1024105	hsa-miR-302d	CLIP-seq
MIRT1024106	hsa-miR-3065-3p	CLIP-seq
MIRT1024107	hsa-miR-3074-3p	CLIP-seq
MIRT1024108	hsa-miR-3125	CLIP-seq
MIRT1024109	hsa-miR-3163	CLIP-seq
MIRT1024110	hsa-miR-3180-5p	CLIP-seq
MIRT1024111	hsa-miR-3194-3p	CLIP-seq
MIRT1024112	hsa-miR-331-3p	CLIP-seq
MIRT1024113	hsa-miR-3609	CLIP-seq
MIRT1024114	hsa-miR-361-5p	CLIP-seq
MIRT1024115	hsa-miR-3646	CLIP-seq
MIRT1024116	hsa-miR-3647-3p	CLIP-seq
MIRT1024117	hsa-miR-3662	CLIP-seq
MIRT1024118	hsa-miR-372	CLIP-seq
MIRT1024119	hsa-miR-373	CLIP-seq
MIRT1024120	hsa-miR-3916	CLIP-seq
MIRT1024121	hsa-miR-4308	CLIP-seq
MIRT1024122	hsa-miR-4454	CLIP-seq
MIRT1024123	hsa-miR-4476	CLIP-seq
MIRT1024124	hsa-miR-4487	CLIP-seq
MIRT1024125	hsa-miR-4494	CLIP-seq
MIRT1024126	hsa-miR-455-3p	CLIP-seq
MIRT1024127	hsa-miR-4633-3p	CLIP-seq
MIRT1024128	hsa-miR-4645-5p	CLIP-seq
MIRT1024129	hsa-miR-4668-3p	CLIP-seq
MIRT1024130	hsa-miR-4673	CLIP-seq
MIRT1024131	hsa-miR-4700-3p	CLIP-seq
MIRT1024132	hsa-miR-4764-5p	CLIP-seq
MIRT1024133	hsa-miR-4766-5p	CLIP-seq
MIRT1024134	hsa-miR-4796-3p	CLIP-seq
MIRT1024135	hsa-miR-499a-5p	CLIP-seq
MIRT1024136	hsa-miR-5095	CLIP-seq
MIRT1024137	hsa-miR-518a-5p	CLIP-seq
MIRT1024138	hsa-miR-519d	CLIP-seq
MIRT1024139	hsa-miR-520a-5p	CLIP-seq
MIRT1024140	hsa-miR-525-5p	CLIP-seq
MIRT1024141	hsa-miR-527	CLIP-seq
MIRT1024142	hsa-miR-539	CLIP-seq
MIRT1024143	hsa-miR-548ah	CLIP-seq
MIRT1024144	hsa-miR-93	CLIP-seq
MIRT1024145	hsa-miR-1260	CLIP-seq
MIRT1024146	hsa-miR-1260b	CLIP-seq
MIRT1024147	hsa-miR-1304	CLIP-seq
MIRT1024148	hsa-miR-186	CLIP-seq
MIRT1024149	hsa-miR-188-3p	CLIP-seq
MIRT1024150	hsa-miR-219-1-3p	CLIP-seq
MIRT1024151	hsa-miR-2467-5p	CLIP-seq
MIRT1024152	hsa-miR-3156-3p	CLIP-seq
MIRT1024153	hsa-miR-3188	CLIP-seq
MIRT1024154	hsa-miR-3975	CLIP-seq
MIRT1024155	hsa-miR-4263	CLIP-seq
MIRT1024156	hsa-miR-4422	CLIP-seq
MIRT1024122	hsa-miR-4454	CLIP-seq
MIRT1024157	hsa-miR-4509	CLIP-seq
MIRT1024158	hsa-miR-4744	CLIP-seq
MIRT1024159	hsa-miR-4799-5p	CLIP-seq
MIRT1024160	hsa-miR-485-5p	CLIP-seq
MIRT1024161	hsa-miR-5096	CLIP-seq
MIRT1024162	hsa-miR-571	CLIP-seq
MIRT1024163	hsa-miR-576-5p	CLIP-seq
MIRT1024164	hsa-miR-581	CLIP-seq
MIRT2003671	hsa-miR-1270	CLIP-seq
MIRT2003672	hsa-miR-1279	CLIP-seq
MIRT1024092	hsa-miR-128	CLIP-seq
MIRT2003673	hsa-miR-129-5p	CLIP-seq
MIRT2003674	hsa-miR-1299	CLIP-seq
MIRT2003675	hsa-miR-139-3p	CLIP-seq
MIRT2003676	hsa-miR-2276	CLIP-seq
MIRT2003677	hsa-miR-3149	CLIP-seq
MIRT1024110	hsa-miR-3180-5p	CLIP-seq
MIRT2003678	hsa-miR-3199	CLIP-seq
MIRT2003679	hsa-miR-3606	CLIP-seq
MIRT2003680	hsa-miR-3661	CLIP-seq
MIRT2003681	hsa-miR-3940-5p	CLIP-seq
MIRT2003682	hsa-miR-411	CLIP-seq
MIRT2003683	hsa-miR-4257	CLIP-seq
MIRT2003684	hsa-miR-4258	CLIP-seq
MIRT2003685	hsa-miR-4267	CLIP-seq
MIRT2003686	hsa-miR-4268	CLIP-seq
MIRT2003687	hsa-miR-4280	CLIP-seq
MIRT2003688	hsa-miR-4284	CLIP-seq
MIRT2003689	hsa-miR-4315	CLIP-seq
MIRT2003690	hsa-miR-4328	CLIP-seq
MIRT2003691	hsa-miR-4438	CLIP-seq
MIRT2003692	hsa-miR-4507	CLIP-seq
MIRT2003693	hsa-miR-4531	CLIP-seq
MIRT2003694	hsa-miR-4532	CLIP-seq
MIRT2003695	hsa-miR-4635	CLIP-seq
MIRT2003696	hsa-miR-4638-5p	CLIP-seq
MIRT2003697	hsa-miR-4645-3p	CLIP-seq
MIRT2003698	hsa-miR-4678	CLIP-seq
MIRT2003699	hsa-miR-4687-3p	CLIP-seq
MIRT2003700	hsa-miR-4735-5p	CLIP-seq
MIRT2003701	hsa-miR-4775	CLIP-seq
MIRT2003702	hsa-miR-4790-5p	CLIP-seq
MIRT2003703	hsa-miR-493	CLIP-seq
MIRT1024136	hsa-miR-5095	CLIP-seq
MIRT1024161	hsa-miR-5096	CLIP-seq
MIRT1024139	hsa-miR-520a-5p	CLIP-seq
MIRT1024140	hsa-miR-525-5p	CLIP-seq
MIRT2003704	hsa-miR-542-3p	CLIP-seq
MIRT2003705	hsa-miR-590-3p	CLIP-seq
MIRT2003706	hsa-miR-618	CLIP-seq
MIRT2003707	hsa-miR-620	CLIP-seq
MIRT2003708	hsa-miR-630	CLIP-seq
MIRT2003709	hsa-miR-631	CLIP-seq
MIRT2003710	hsa-miR-633	CLIP-seq
MIRT2003711	hsa-miR-720	CLIP-seq
MIRT2003712	hsa-miR-766	CLIP-seq
MIRT2003713	hsa-miR-875-3p	CLIP-seq
MIRT2003714	hsa-miR-889	CLIP-seq
MIRT2003715	hsa-miR-921	CLIP-seq
MIRT1024090	hsa-miR-106a	CLIP-seq
MIRT1024091	hsa-miR-106b	CLIP-seq
MIRT2236477	hsa-miR-1234	CLIP-seq
MIRT1024096	hsa-miR-17	CLIP-seq
MIRT1024097	hsa-miR-20a	CLIP-seq
MIRT1024098	hsa-miR-20b	CLIP-seq
MIRT1024102	hsa-miR-302a	CLIP-seq
MIRT1024103	hsa-miR-302b	CLIP-seq
MIRT1024104	hsa-miR-302c	CLIP-seq
MIRT1024105	hsa-miR-302d	CLIP-seq
MIRT2003678	hsa-miR-3199	CLIP-seq
MIRT1024118	hsa-miR-372	CLIP-seq
MIRT1024119	hsa-miR-373	CLIP-seq
MIRT2003684	hsa-miR-4258	CLIP-seq
MIRT2003688	hsa-miR-4284	CLIP-seq
MIRT2003691	hsa-miR-4438	CLIP-seq
MIRT2003700	hsa-miR-4735-5p	CLIP-seq
MIRT2003701	hsa-miR-4775	CLIP-seq
MIRT1024136	hsa-miR-5095	CLIP-seq
MIRT1024138	hsa-miR-519d	CLIP-seq
MIRT2003705	hsa-miR-590-3p	CLIP-seq
MIRT1024144	hsa-miR-93	CLIP-seq
MIRT1024101	hsa-miR-2861	CLIP-seq
MIRT2003673	hsa-miR-129-5p	CLIP-seq
MIRT2003675	hsa-miR-139-3p	CLIP-seq
MIRT2003677	hsa-miR-3149	CLIP-seq
MIRT2003682	hsa-miR-411	CLIP-seq
MIRT2450448	hsa-miR-4294	CLIP-seq
MIRT2003689	hsa-miR-4315	CLIP-seq
MIRT2003700	hsa-miR-4735-5p	CLIP-seq
MIRT2003701	hsa-miR-4775	CLIP-seq
MIRT2003702	hsa-miR-4790-5p	CLIP-seq
MIRT2003705	hsa-miR-590-3p	CLIP-seq
MIRT2003711	hsa-miR-720	CLIP-seq
MIRT2540182	hsa-miR-1253	CLIP-seq
MIRT2540183	hsa-miR-1254	CLIP-seq
MIRT2003673	hsa-miR-129-5p	CLIP-seq
MIRT2003674	hsa-miR-1299	CLIP-seq
MIRT2540184	hsa-miR-135a	CLIP-seq
MIRT2540185	hsa-miR-135b	CLIP-seq
MIRT1024148	hsa-miR-186	CLIP-seq
MIRT2540186	hsa-miR-1910	CLIP-seq
MIRT2003676	hsa-miR-2276	CLIP-seq
MIRT1024101	hsa-miR-2861	CLIP-seq
MIRT2540187	hsa-miR-3116	CLIP-seq
MIRT2003677	hsa-miR-3149	CLIP-seq
MIRT2540188	hsa-miR-3150b-3p	CLIP-seq
MIRT1024110	hsa-miR-3180-5p	CLIP-seq
MIRT1024112	hsa-miR-331-3p	CLIP-seq
MIRT2540189	hsa-miR-3613-3p	CLIP-seq
MIRT2540190	hsa-miR-3663-5p	CLIP-seq
MIRT2540191	hsa-miR-3918	CLIP-seq
MIRT2540192	hsa-miR-3921	CLIP-seq
MIRT2540193	hsa-miR-3938	CLIP-seq
MIRT2003682	hsa-miR-411	CLIP-seq
MIRT2540194	hsa-miR-4254	CLIP-seq
MIRT2003683	hsa-miR-4257	CLIP-seq
MIRT2003684	hsa-miR-4258	CLIP-seq
MIRT1024155	hsa-miR-4263	CLIP-seq
MIRT2003685	hsa-miR-4267	CLIP-seq
MIRT2003687	hsa-miR-4280	CLIP-seq
MIRT2003688	hsa-miR-4284	CLIP-seq
MIRT1024121	hsa-miR-4308	CLIP-seq
MIRT2540195	hsa-miR-4421	CLIP-seq
MIRT1024156	hsa-miR-4422	CLIP-seq
MIRT1024157	hsa-miR-4509	CLIP-seq
MIRT2540196	hsa-miR-4512	CLIP-seq
MIRT2003694	hsa-miR-4532	CLIP-seq
MIRT2003696	hsa-miR-4638-5p	CLIP-seq
MIRT2003697	hsa-miR-4645-3p	CLIP-seq
MIRT2540197	hsa-miR-4649-3p	CLIP-seq
MIRT2540198	hsa-miR-4653-5p	CLIP-seq
MIRT2003699	hsa-miR-4687-3p	CLIP-seq
MIRT2540199	hsa-miR-4689	CLIP-seq
MIRT1024131	hsa-miR-4700-3p	CLIP-seq
MIRT2540200	hsa-miR-4704-5p	CLIP-seq
MIRT2003700	hsa-miR-4735-5p	CLIP-seq
MIRT1024158	hsa-miR-4744	CLIP-seq
MIRT1024132	hsa-miR-4764-5p	CLIP-seq
MIRT2003701	hsa-miR-4775	CLIP-seq
MIRT2540201	hsa-miR-4784	CLIP-seq
MIRT1024159	hsa-miR-4799-5p	CLIP-seq
MIRT1024136	hsa-miR-5095	CLIP-seq
MIRT1024139	hsa-miR-520a-5p	CLIP-seq
MIRT2540202	hsa-miR-520d-5p	CLIP-seq
MIRT2540203	hsa-miR-524-5p	CLIP-seq
MIRT1024140	hsa-miR-525-5p	CLIP-seq
MIRT2003704	hsa-miR-542-3p	CLIP-seq
MIRT1024163	hsa-miR-576-5p	CLIP-seq
MIRT2003705	hsa-miR-590-3p	CLIP-seq
MIRT2540204	hsa-miR-600	CLIP-seq
MIRT2540205	hsa-miR-7	CLIP-seq
MIRT2003712	hsa-miR-766	CLIP-seq
MIRT2003713	hsa-miR-875-3p	CLIP-seq
MIRT2540182	hsa-miR-1253	CLIP-seq
MIRT2003673	hsa-miR-129-5p	CLIP-seq
MIRT2003674	hsa-miR-1299	CLIP-seq
MIRT2540184	hsa-miR-135a	CLIP-seq
MIRT2540185	hsa-miR-135b	CLIP-seq
MIRT1024148	hsa-miR-186	CLIP-seq
MIRT2540186	hsa-miR-1910	CLIP-seq
MIRT2003676	hsa-miR-2276	CLIP-seq
MIRT1024101	hsa-miR-2861	CLIP-seq
MIRT2003677	hsa-miR-3149	CLIP-seq
MIRT2540188	hsa-miR-3150b-3p	CLIP-seq
MIRT1024110	hsa-miR-3180-5p	CLIP-seq
MIRT1024112	hsa-miR-331-3p	CLIP-seq
MIRT2540189	hsa-miR-3613-3p	CLIP-seq
MIRT2540190	hsa-miR-3663-5p	CLIP-seq
MIRT2540192	hsa-miR-3921	CLIP-seq
MIRT2540193	hsa-miR-3938	CLIP-seq
MIRT2003682	hsa-miR-411	CLIP-seq
MIRT2003683	hsa-miR-4257	CLIP-seq
MIRT2003684	hsa-miR-4258	CLIP-seq
MIRT1024155	hsa-miR-4263	CLIP-seq
MIRT2003685	hsa-miR-4267	CLIP-seq
MIRT2003687	hsa-miR-4280	CLIP-seq
MIRT2003688	hsa-miR-4284	CLIP-seq
MIRT1024121	hsa-miR-4308	CLIP-seq
MIRT2003690	hsa-miR-4328	CLIP-seq
MIRT2540195	hsa-miR-4421	CLIP-seq
MIRT1024156	hsa-miR-4422	CLIP-seq
MIRT1024157	hsa-miR-4509	CLIP-seq
MIRT2003694	hsa-miR-4532	CLIP-seq
MIRT2003696	hsa-miR-4638-5p	CLIP-seq
MIRT2003697	hsa-miR-4645-3p	CLIP-seq
MIRT2540197	hsa-miR-4649-3p	CLIP-seq
MIRT2540198	hsa-miR-4653-5p	CLIP-seq
MIRT2003699	hsa-miR-4687-3p	CLIP-seq
MIRT2540199	hsa-miR-4689	CLIP-seq
MIRT1024131	hsa-miR-4700-3p	CLIP-seq
MIRT2540200	hsa-miR-4704-5p	CLIP-seq
MIRT2003700	hsa-miR-4735-5p	CLIP-seq
MIRT1024158	hsa-miR-4744	CLIP-seq
MIRT1024132	hsa-miR-4764-5p	CLIP-seq
MIRT2003701	hsa-miR-4775	CLIP-seq
MIRT2540201	hsa-miR-4784	CLIP-seq
MIRT1024159	hsa-miR-4799-5p	CLIP-seq
MIRT1024136	hsa-miR-5095	CLIP-seq
MIRT1024139	hsa-miR-520a-5p	CLIP-seq
MIRT2540202	hsa-miR-520d-5p	CLIP-seq
MIRT2540203	hsa-miR-524-5p	CLIP-seq
MIRT1024140	hsa-miR-525-5p	CLIP-seq
MIRT2003704	hsa-miR-542-3p	CLIP-seq
MIRT1024163	hsa-miR-576-5p	CLIP-seq
MIRT2003705	hsa-miR-590-3p	CLIP-seq
MIRT2540204	hsa-miR-600	CLIP-seq
MIRT2003710	hsa-miR-633	CLIP-seq
MIRT2540205	hsa-miR-7	CLIP-seq
MIRT2003712	hsa-miR-766	CLIP-seq
MIRT2003713	hsa-miR-875-3p	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	NAS	9606987
GO:0005096	Function	GTPase activator activity	IDA	27677260
GO:0005096	Function	GTPase activator activity	IDA	10521509
GO:0005515	Function	Protein binding	IPI	12606627, 19376773, 25036637, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IDA	10521509
GO:0005829	Component	Cytosol	TAS
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	NAS	9606987
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007212	Process	G protein-coupled dopamine receptor signaling pathway	IBA
GO:0007212	Process	G protein-coupled dopamine receptor signaling pathway	IDA	27677260
GO:0016020	Component	Membrane	IEA
GO:0030159	Function	Signaling receptor complex adaptor activity	IBA
GO:0030425	Component	Dendrite	IEA
GO:0031682	Function	G-protein gamma-subunit binding	IPI	12606627
GO:0036367	Process	Light adaption	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	10521509
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051087	Function	Protein-folding chaperone binding	IPI	19376773
GO:0051286	Component	Cell tip	IEA
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0098793	Component	Presynapse	IEA
GO:1901386	Process	Negative regulation of voltage-gated calcium channel activity	IDA	11007869, 12606627
GO:1902773	Component	GTPase activator complex	TAS	27677260
GO:1990603	Process	Dark adaptation	IEA

MIM	HGNC	e!Ensembl
604447	4401	ENSG00000069966

O14775

Protein name

Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)

Protein function

Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating

PDB

7EWP , 7EWR , 8SG8 , 8SG9 , 8SGC , 8SGL , 8SH9 , 8SHA , 8SHD , 8SHE , 8SHF , 8SHG , 8SHL , 8SHN , 8SHO , 8SHP , 8SHQ , 8SHT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	95 → 133	WD domain, G-beta repeat	Repeat
PF00400	WD40	227 → 267	WD domain, G-beta repeat	Repeat
PF00400	WD40	271 → 309	WD domain, G-beta repeat	Repeat
PF00400	WD40	320 → 353	WD domain, G-beta repeat	Repeat
PF00400	WD40	357 → 394	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9606987}.

Sequence

MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSE
AESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRI
VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK
NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADV
LCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGS
DDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV
SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA

Sequence length

395

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer		Activation of G protein gated Potassium channels G-protein activation Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Show/Hide Causal Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormality of the nervous system	Likely pathogenic; Pathogenic	rs2141193854	RCV001814509
Attention deficit hyperactivity disorder	Pathogenic	rs761399728	RCV000239906
Cardiovascular phenotype	Likely pathogenic	rs1332666675	RCV005405047
Delayed speech and language development	Pathogenic	rs761399728	RCV000239906
Global developmental delay	Pathogenic; Likely pathogenic	rs761399728	RCV000239906 RCV001255386
GNB5-related disorder	Pathogenic; Likely pathogenic	rs768022031, rs2543008738, rs886041055	RCV004528520 RCV004529128 RCV003596256
Gnb5-related intellectual disability-cardiac arrhythmia syndrome	Pathogenic; Likely pathogenic	rs768022031, rs201041536, rs2141181367, rs1379641378, rs761399728, rs886041054, rs773902879, rs886041055, rs749597091, rs2034001586, rs755832695, rs2543008806, rs1085307675	RCV001580374 RCV003989713 RCV002250024 RCV002262192 RCV000709974 RCV000258840 RCV000258819 RCV000258827 RCV000258821 RCV003321474 RCV003321475 RCV003321476 RCV003321477 RCV000709973 RCV001250226 RCV001580375
GNB5-reled disorder	Pathogenic	rs768022031	RCV005225440
Language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia	Likely pathogenic; Pathogenic	rs2141193854, rs1379641378, rs761399728, rs1085307675, rs749597091	RCV005867158 RCV002262192 RCV000258832 RCV000709973 RCV005252943
LODDER-MERLA SYNDROME, TYPE 2, WITH DEVELOPMENTAL DELAY AND CARDIAC ARRHYTHMIA	Pathogenic	rs1085307675	RCV003321635

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs117479818	RCV005911513
Clear cell carcinoma of kidney	Benign	rs34637551	RCV005905163
Fraser syndrome 3	Uncertain significance	rs1253307264	RCV001251008
Lung cancer	Benign	rs34637551	RCV005905166
Ovarian serous cystadenocarcinoma	Likely benign; Benign	rs117479818, rs34637551	RCV005911514 RCV005905165
Sarcoma	Benign; Uncertain significance	rs34637551, rs1253307264	RCV005905164 RCV005909213
Uterine corpus endometrial carcinoma	Benign	rs34637551	RCV005905167

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
3 methylcrotonyl CoA carboxylase 1 deficiency	Associate	34573334
Alzheimer Disease	Associate	32525932
Anxiety	Associate	34684344
Arrhythmias Cardiac	Associate	40565581
Asymptomatic Diseases	Associate	32525932
Bradycardia	Associate	34573334
Carcinoma Embryonal	Associate	8679447
Cognition Disorders	Associate	32525932
Colorectal Neoplasms	Associate	30719834
Cytomegalovirus Infections	Associate	31438890
Diabetes Mellitus Type 1	Associate	40565581
Diabetes Mellitus Type 2	Associate	32525932
Epilepsy	Associate	31479876
Genetic Diseases Inborn	Associate	31479876
Heart Arrest	Associate	34573334
Intellectual Disability	Associate	31479876, 34573334
Muscle Hypotonia	Associate	31479876
Osteoporosis	Associate	37335694
Parkinson Disease	Associate	35342758, 38255780
Prader Willi Syndrome	Associate	40565581
Pre Eclampsia	Stimulate	34894939
Prostatic Neoplasms	Associate	23773523
Seizures	Associate	38166692
Seminoma	Inhibit	8679447
Sick Sinus Syndrome	Associate	31479876
Uniparental disomy of chromosome 2	Associate	40565581
Vision Disorders	Associate	31479876

GNB5 (G protein subunit beta 5)