Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10672
Gene name Gene Name - the full gene name approved by the HGNC.
G protein subunit alpha 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GNA13
Synonyms (NCBI Gene) Gene synonyms aliases
G13, HG1N
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q24.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001546 hsa-miR-155-5p pSILAC 18668040
MIRT001546 hsa-miR-155-5p Proteomics;Other 18668040
MIRT023441 hsa-miR-30b-5p Sequencing 20371350
MIRT023990 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT028679 hsa-miR-30a-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001664 Function G protein-coupled receptor binding IBA 21873635
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 10026210, 12681510, 18703424, 20300064, 23773523, 23994616
GO:0005525 Function GTP binding IEA
GO:0005634 Component Nucleus IDA 18703424
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604406 4381 ENSG00000120063
Protein
UniProt ID Q14344
Protein name Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16705036, PubMed:16787920, PubMed:27084452). Activates effector molecule RhoA by bindi
PDB 7SF7 , 7SF8 , 7T6B , 7YDH , 8H8J , 8KGG , 8ZX4 , 8ZX5 , 9GE2 , 9GE3 , 9IY8 , 9IZH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00503 G-alpha 28 366 G-protein alpha subunit Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa
Sequence
Sequence length 377
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Hormone signaling
Vascular smooth muscle contraction
Apelin signaling pathway
Platelet activation
Long-term depression
Regulation of actin cytoskeleton
Parathyroid hormone synthesis, secretion and action
Pathogenic Escherichia coli infection
Human cytomegalovirus infection
Pathways in cancer
  NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
Thrombin signalling through proteinase activated receptors (PARs)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Burkitt`s lymphoma Burkitt Lymphoma, Burkitt Leukemia rs28933407, rs121918683, rs121918684 23143597
Diffuse lymphoma Diffuse Large B-Cell Lymphoma rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 36418457
Breast Neoplasms Associate 18493596, 25889182
Burkitt Lymphoma Associate 23143597, 30567752, 36201743
Carcinogenesis Associate 11136230, 16787920, 31636124
Carcinoma Hepatocellular Associate 27883022
Celiac Disease Associate 22136669
Colonic Neoplasms Associate 25922072
Colorectal Neoplasms Associate 24958816, 25193986
Death Associate 36606708
Drug Resistant Epilepsy Associate 36606708