IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10643
Gene name Gene Name - the full gene name approved by the HGNC.
Insulin like growth factor 2 mRNA binding protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IGF2BP3
Synonyms (NCBI Gene) Gene synonyms aliases
CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p15.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5` UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded prot
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(529)
miRTarBase ID miRNA Experiments Reference
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT026059 hsa-miR-196a-5p Sequencing 20371350
MIRT032130 hsa-let-7d-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(37)
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IDA 29476152
GO:0000932 Component P-body IEA
GO:0001817 Process Regulation of cytokine production IC 9891060
GO:0001817 Process Regulation of cytokine production IEA
GO:0003676 Function Nucleic acid binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608259 28868 ENSG00000136231
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O00425
Protein name Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Protein function RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcr
PDB 2E44 , 6FQ1 , 6FQR , 6GQE , 6GX6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 4 → 69 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 83 → 150 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00013 KH_1 197 → 262 KH domain Domain
PF00013 KH_1 278 → 345 KH domain Domain
PF00013 KH_1 407 → 472 KH domain Domain
PF00013 KH_1 489 → 555 KH domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in tes
Sequence
Sequence length 579
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Show/Hide Text Mining Associations (77)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 35569444
Adenocarcinoma of Lung Associate 18098206, 28381175
Aortic Aneurysm Thoracic Associate 35730141
Arthritis Rheumatoid Associate 36582238
Astrocytoma Associate 23584203, 25521223
Autosomal Recessive Primary Microcephaly Associate 34402213
Brain Neoplasms Associate 34008756
Breast Neoplasms Associate 28523716, 29847788, 30423315, 34287743, 37474008, 37705505, 37861451
Carcinogenesis Associate 35217832, 35845940
Carcinoma Hepatocellular Associate 26327240, 27387388, 33297932, 34312475, 34647424, 35833147, 35963644, 37234166, 37301543, 38059827