Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10642
Gene name Gene Name - the full gene name approved by the HGNC.
Insulin like growth factor 2 mRNA binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IGF2BP1
Synonyms (NCBI Gene) Gene synonyms aliases
CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
Transcription factors
Transcription factor Regulation Reference
MYC Activation 21252116
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IC 9891060
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA 21873635
GO:0003729 Function MRNA binding IDA 17101699, 17289661
GO:0003730 Function MRNA 3'-UTR binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608288 28866 ENSG00000159217
Protein
UniProt ID Q9NZI8
Protein name Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
Protein function RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcript
PDB 3KRM , 6QEY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 4 69 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 83 150 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00013 KH_1 197 262 KH domain Domain
PF00013 KH_1 278 345 KH domain Domain
PF00013 KH_1 407 472 KH domain Domain
PF00013 KH_1 489 555 KH domain Domain
Tissue specificity TISSUE SPECIFICITY: Mainly expressed in the embryo, including in fetal liver, fetal lung, fetal kidney, fetal thymus (at protein level). Also expressed follicles of ovary, as well as in gonocytes of testis, spermatogonia, semen, oocytes and placenta (at p
Sequence
Sequence length 577
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MicroRNAs in cancer   Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
MAPK6/MAPK4 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 28714975
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Myocardial Infarction Myocardial Infarction GWAS
Insomnia Insomnia GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 28787442
Adenocarcinoma Follicular Associate 32719445
Adenocarcinoma of Lung Associate 28381175, 35860262, 36650118, 36737405, 37047493
Breast Neoplasms Associate 22266909, 29669595, 33469161, 33629308, 34707800, 36632454, 36647722
Calcinosis Cutis Stimulate 29369405
Carcinogenesis Associate 36308276
Carcinoma Hepatocellular Associate 26547929, 28244848, 28677801, 28975985, 37024475, 37137887, 37891494, 37926706, 38048735
Carcinoma Non Small Cell Lung Associate 28381175, 36074102, 36672208
Carcinoma Pancreatic Ductal Associate 32545414
Carcinoma Renal Cell Associate 26332146, 36516496