GAS2L1 (growth arrest specific 2 like 1)

Gene

• Entrez ID: 10634
• Gene name: Growth arrest specific 2 like 1
• Gene symbol: GAS2L1
• Synonyms (NCBI Gene): GAR22
• Chromosome: 22
• Chromosome location: 22q12.2
• Summary: This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002903	hsa-miR-124-3p	Microarray, qRT-PCR	16549876
MIRT002903	hsa-miR-124-3p	qRT-PCR;Other	16549876
MIRT1012262	hsa-miR-1915	CLIP-seq
MIRT1012263	hsa-miR-3125	CLIP-seq
MIRT1012264	hsa-miR-3916	CLIP-seq
MIRT1012265	hsa-miR-451b	CLIP-seq
MIRT1012266	hsa-miR-4640-5p	CLIP-seq
MIRT1012267	hsa-miR-4726-3p	CLIP-seq
MIRT1012268	hsa-miR-4726-5p	CLIP-seq
MIRT1921611	hsa-miR-1976	CLIP-seq
MIRT1921612	hsa-miR-483-3p	CLIP-seq
MIRT1921611	hsa-miR-1976	CLIP-seq
MIRT1921612	hsa-miR-483-3p	CLIP-seq
MIRT2233263	hsa-miR-1	CLIP-seq
MIRT2233264	hsa-miR-125a-5p	CLIP-seq
MIRT2233265	hsa-miR-125b	CLIP-seq
MIRT2233266	hsa-miR-1827	CLIP-seq
MIRT2233267	hsa-miR-206	CLIP-seq
MIRT2233268	hsa-miR-2467-3p	CLIP-seq
MIRT2233269	hsa-miR-298	CLIP-seq
MIRT2233270	hsa-miR-3144-5p	CLIP-seq
MIRT2233271	hsa-miR-3154	CLIP-seq
MIRT2233272	hsa-miR-3191	CLIP-seq
MIRT2233273	hsa-miR-361-3p	CLIP-seq
MIRT2233274	hsa-miR-4257	CLIP-seq
MIRT2233275	hsa-miR-4283	CLIP-seq
MIRT2233276	hsa-miR-4289	CLIP-seq
MIRT2233277	hsa-miR-4319	CLIP-seq
MIRT2233278	hsa-miR-4652-5p	CLIP-seq
MIRT2233279	hsa-miR-4667-5p	CLIP-seq
MIRT2233280	hsa-miR-4700-5p	CLIP-seq
MIRT2233281	hsa-miR-4717-5p	CLIP-seq
MIRT2233282	hsa-miR-4732-3p	CLIP-seq
MIRT2233283	hsa-miR-4753-5p	CLIP-seq
MIRT2233284	hsa-miR-574-3p	CLIP-seq
MIRT2233285	hsa-miR-613	CLIP-seq
MIRT2233286	hsa-miR-615-5p	CLIP-seq
MIRT2233287	hsa-miR-637	CLIP-seq
MIRT2233288	hsa-miR-670	CLIP-seq
MIRT2450058	hsa-miR-3918	CLIP-seq
MIRT2450059	hsa-miR-4632	CLIP-seq
MIRT2450060	hsa-miR-4691-3p	CLIP-seq
MIRT2450061	hsa-miR-4707-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001578	Process	Microtubule bundle formation	IBA
GO:0001578	Process	Microtubule bundle formation	IEA
GO:0001578	Process	Microtubule bundle formation	IMP	12584248, 24706950
GO:0001725	Component	Stress fiber	IBA
GO:0001725	Component	Stress fiber	IDA	12584248
GO:0001725	Component	Stress fiber	IEA
GO:0005515	Function	Protein binding	IPI	24706950, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12584248
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IDA	12584248
GO:0005884	Component	Actin filament	IMP	24706950
GO:0007026	Process	Negative regulation of microtubule depolymerization	IEA
GO:0007026	Process	Negative regulation of microtubule depolymerization	IMP	12584248
GO:0008017	Function	Microtubule binding	IDA	12584248
GO:0008017	Function	Microtubule binding	IEA
GO:0008093	Function	Cytoskeletal anchor activity	IDA	12584248
GO:0008093	Function	Cytoskeletal anchor activity	IEA
GO:0009267	Process	Cellular response to starvation	ISS	12584248
GO:0031110	Process	Regulation of microtubule polymerization or depolymerization	IBA
GO:0031110	Process	Regulation of microtubule polymerization or depolymerization	IMP	24706950
GO:0035371	Component	Microtubule plus-end	IBA
GO:0035371	Component	Microtubule plus-end	IMP	24706950
GO:0051015	Function	Actin filament binding	IBA
GO:0051764	Process	Actin crosslink formation	IBA
GO:1904825	Process	Protein localization to microtubule plus-end	IBA
GO:1904825	Process	Protein localization to microtubule plus-end	IDA	24706950
GO:1904825	Process	Protein localization to microtubule plus-end	IEA

Other IDs

• MIM: 602128
• HGNC: 16955
• e!Ensembl: ENSG00000185340

Protein

• UniProt ID: Q99501
• Protein name: GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1)
• Protein function: Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	27 → 149	Calponin homology (CH) domain	Domain
  PF02187	GAS2	208 → 276	Growth-Arrest-Specific Protein 2 Domain	Family

• Sequence:

  MADPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGFLTGLATGT
  TLCQHANAVTEAARALAAARPARGVAFQAHSVVPGSFMARDNVATFIGWCRVELGVPEVL
  MFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQFEQEIERELRAAPPAPNAPAA
  GEDTTETAPAPGTPARGPRMTPSDLRNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDS
  SLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTT
  SPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDSDSSAS
  SAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRGRPRGAPGG
  RGAQLSVPSPARRARSQSREEQAVLLVRRDRDGQHSWVPRGRGSGGSGRSTPQTPRARSP
  AAPRLSRVSSPSPELGTTPASIFRTPLQLDPQQEQQLFRRLEEEFLANARALEAVASVTP
  TGPVPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANGLPGPRSQALSS
  SSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPA
  ELGTWHALHSVTPRAEPDSWM

• Sequence length: 681