Gene Gene information from NCBI Gene database.
Entrez ID 10611
Gene name PDZ and LIM domain 5
Gene symbol PDLIM5
Synonyms (NCBI Gene)
ENHENH1L9LIM
Chromosome 4
Chromosome location 4q22.3
Summary This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in
miRNA miRNA information provided by mirtarbase database.
504
miRTarBase ID miRNA Experiments Reference
MIRT001527 hsa-miR-155-5p pSILAC 18668040
MIRT001527 hsa-miR-155-5p Western blot 20584899
MIRT032035 hsa-miR-16-5p Proteomics 18668040
MIRT051014 hsa-miR-17-5p CLASH 23622248
MIRT438719 hsa-miR-133a-3p Luciferase reporter assayqRT-PCRWestern blot 23968734
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IBA
GO:0003779 Function Actin binding IBA
GO:0003779 Function Actin binding ISS
GO:0005080 Function Protein kinase C binding ISS
GO:0005515 Function Protein binding IPI 16549780, 25416956, 31515488, 32814053
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605904 17468 ENSG00000163110
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96HC4
Protein name PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)
Protein function May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isofo
PDB 2DAR , 2UZC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00595 PDZ 4 82 PDZ domain Domain
PF15936 DUF4749 213 305 Domain of unknown function (DUF4749) Family
PF00412 LIM 420 475 LIM domain Domain
PF00412 LIM 479 534 LIM domain Domain
PF00412 LIM 538 594 LIM domain Domain
Tissue specificity TISSUE SPECIFICITY: Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression. {ECO:0000269|PubMed:10429367, ECO:0000269|PubMed:16044170, ECO:0000269|PubMed:162
Sequence
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG
MTHLEAQNKIKGCTGSLNMTLQ
RASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTST
NNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH
ANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPR
KHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEA
DNTKK
ANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKS
PSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMC
AHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFF
APECG
RCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF
GTICHG
CEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSV
NF
Sequence length 596
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Cytoskeleton in muscle cells