CDC42EP3 (CDC42 effector protein 3)

Gene

• Entrez ID: 10602
• Gene name: CDC42 effector protein 3
• Gene symbol: CDC42EP3
• Synonyms (NCBI Gene): BORG2, CEP3, UB1
• Chromosome: 2
• Chromosome location: 2p22.2
• Summary: This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is i

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022352	hsa-miR-124-3p	Microarray	18668037
MIRT023231	hsa-miR-122-5p	Microarray	17612493
MIRT440970	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440970	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT878126	hsa-miR-202	CLIP-seq
MIRT878127	hsa-miR-3200-3p	CLIP-seq
MIRT878128	hsa-miR-4678	CLIP-seq
MIRT878129	hsa-miR-4723-5p	CLIP-seq
MIRT878130	hsa-miR-4724-3p	CLIP-seq
MIRT1546344	hsa-miR-2276	CLIP-seq
MIRT1546345	hsa-miR-3616-5p	CLIP-seq
MIRT1546346	hsa-miR-3647-5p	CLIP-seq
MIRT1546347	hsa-miR-4251	CLIP-seq
MIRT1546348	hsa-miR-4711-3p	CLIP-seq
MIRT1546349	hsa-miR-548b-3p	CLIP-seq
MIRT1546350	hsa-miR-573	CLIP-seq
MIRT1960261	hsa-miR-1273d	CLIP-seq
MIRT1960262	hsa-miR-1323	CLIP-seq
MIRT1960263	hsa-miR-4668-3p	CLIP-seq
MIRT1960264	hsa-miR-4672	CLIP-seq
MIRT1960265	hsa-miR-548a-3p	CLIP-seq
MIRT1960266	hsa-miR-548e	CLIP-seq
MIRT1960267	hsa-miR-548f	CLIP-seq
MIRT1960268	hsa-miR-548o	CLIP-seq
MIRT1960269	hsa-miR-605	CLIP-seq
MIRT2197069	hsa-miR-103b	CLIP-seq
MIRT2197070	hsa-miR-1183	CLIP-seq
MIRT2197071	hsa-miR-1236	CLIP-seq
MIRT2197072	hsa-miR-1273g	CLIP-seq
MIRT2197073	hsa-miR-129-3p	CLIP-seq
MIRT2197074	hsa-miR-141	CLIP-seq
MIRT2197075	hsa-miR-200a	CLIP-seq
MIRT2197076	hsa-miR-200b	CLIP-seq
MIRT2197077	hsa-miR-200c	CLIP-seq
MIRT2197078	hsa-miR-205	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2197080	hsa-miR-338-5p	CLIP-seq
MIRT2197081	hsa-miR-3660	CLIP-seq
MIRT2197082	hsa-miR-369-3p	CLIP-seq
MIRT2197083	hsa-miR-371-3p	CLIP-seq
MIRT2197084	hsa-miR-371b-3p	CLIP-seq
MIRT2197085	hsa-miR-374a	CLIP-seq
MIRT2197086	hsa-miR-374b	CLIP-seq
MIRT2197087	hsa-miR-376a	CLIP-seq
MIRT2197088	hsa-miR-376b	CLIP-seq
MIRT2197089	hsa-miR-3926	CLIP-seq
MIRT2197090	hsa-miR-3942-5p	CLIP-seq
MIRT2197091	hsa-miR-4282	CLIP-seq
MIRT2197092	hsa-miR-429	CLIP-seq
MIRT2197093	hsa-miR-4318	CLIP-seq
MIRT2197094	hsa-miR-4434	CLIP-seq
MIRT2197095	hsa-miR-4516	CLIP-seq
MIRT2197096	hsa-miR-4526	CLIP-seq
MIRT2197097	hsa-miR-4531	CLIP-seq
MIRT2197098	hsa-miR-4645-3p	CLIP-seq
MIRT2197099	hsa-miR-4690-3p	CLIP-seq
MIRT2197100	hsa-miR-4698	CLIP-seq
MIRT2197101	hsa-miR-4703-5p	CLIP-seq
MIRT2197102	hsa-miR-4710	CLIP-seq
MIRT1546348	hsa-miR-4711-3p	CLIP-seq
MIRT878130	hsa-miR-4724-3p	CLIP-seq
MIRT2197103	hsa-miR-4753-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2197105	hsa-miR-4792	CLIP-seq
MIRT2197106	hsa-miR-515-3p	CLIP-seq
MIRT2197107	hsa-miR-519e	CLIP-seq
MIRT1546349	hsa-miR-548b-3p	CLIP-seq
MIRT2197108	hsa-miR-548s	CLIP-seq
MIRT2197109	hsa-miR-671-5p	CLIP-seq
MIRT2197110	hsa-miR-942	CLIP-seq
MIRT2197074	hsa-miR-141	CLIP-seq
MIRT2197075	hsa-miR-200a	CLIP-seq
MIRT2427223	hsa-miR-101	CLIP-seq
MIRT2427224	hsa-miR-144	CLIP-seq
MIRT2197076	hsa-miR-200b	CLIP-seq
MIRT2197077	hsa-miR-200c	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2197082	hsa-miR-369-3p	CLIP-seq
MIRT2197085	hsa-miR-374a	CLIP-seq
MIRT2197086	hsa-miR-374b	CLIP-seq
MIRT2197091	hsa-miR-4282	CLIP-seq
MIRT2197092	hsa-miR-429	CLIP-seq
MIRT2197098	hsa-miR-4645-3p	CLIP-seq
MIRT2197100	hsa-miR-4698	CLIP-seq
MIRT1546348	hsa-miR-4711-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2427225	hsa-miR-582-5p	CLIP-seq
MIRT2197091	hsa-miR-4282	CLIP-seq
MIRT2197098	hsa-miR-4645-3p	CLIP-seq
MIRT2197100	hsa-miR-4698	CLIP-seq
MIRT2500301	hsa-miR-124	CLIP-seq
MIRT2500302	hsa-miR-183	CLIP-seq
MIRT2500303	hsa-miR-22	CLIP-seq
MIRT1546344	hsa-miR-2276	CLIP-seq
MIRT2500304	hsa-miR-302a	CLIP-seq
MIRT2500305	hsa-miR-302b	CLIP-seq
MIRT2500306	hsa-miR-302c	CLIP-seq
MIRT2500307	hsa-miR-302d	CLIP-seq
MIRT2500308	hsa-miR-302e	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2500309	hsa-miR-3154	CLIP-seq
MIRT2500310	hsa-miR-3163	CLIP-seq
MIRT2500311	hsa-miR-3170	CLIP-seq
MIRT2500312	hsa-miR-3171	CLIP-seq
MIRT2500313	hsa-miR-3189-3p	CLIP-seq
MIRT2500314	hsa-miR-3617	CLIP-seq
MIRT2500315	hsa-miR-3622a-5p	CLIP-seq
MIRT2500316	hsa-miR-3654	CLIP-seq
MIRT2500317	hsa-miR-3662	CLIP-seq
MIRT2500318	hsa-miR-3668	CLIP-seq
MIRT2500319	hsa-miR-3680	CLIP-seq
MIRT2500320	hsa-miR-372	CLIP-seq
MIRT2500321	hsa-miR-373	CLIP-seq
MIRT2500322	hsa-miR-378	CLIP-seq
MIRT2500323	hsa-miR-378b	CLIP-seq
MIRT2500324	hsa-miR-378c	CLIP-seq
MIRT2500325	hsa-miR-378d	CLIP-seq
MIRT2500326	hsa-miR-378e	CLIP-seq
MIRT2500327	hsa-miR-378f	CLIP-seq
MIRT2500328	hsa-miR-378h	CLIP-seq
MIRT2500329	hsa-miR-378i	CLIP-seq
MIRT2500330	hsa-miR-422a	CLIP-seq
MIRT2500331	hsa-miR-4290	CLIP-seq
MIRT2500332	hsa-miR-4464	CLIP-seq
MIRT2500333	hsa-miR-4480	CLIP-seq
MIRT2500334	hsa-miR-4502	CLIP-seq
MIRT2500335	hsa-miR-4520a-5p	CLIP-seq
MIRT2500336	hsa-miR-4520b-5p	CLIP-seq
MIRT2500337	hsa-miR-4522	CLIP-seq
MIRT2500338	hsa-miR-4655-3p	CLIP-seq
MIRT2500339	hsa-miR-4662a-3p	CLIP-seq
MIRT2500340	hsa-miR-4684-5p	CLIP-seq
MIRT2500341	hsa-miR-4696	CLIP-seq
MIRT2500342	hsa-miR-4718	CLIP-seq
MIRT2500343	hsa-miR-4738-3p	CLIP-seq
MIRT2500344	hsa-miR-4748	CLIP-seq
MIRT2500345	hsa-miR-4772-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2500346	hsa-miR-4776-3p	CLIP-seq
MIRT2500347	hsa-miR-4796-5p	CLIP-seq
MIRT2500348	hsa-miR-506	CLIP-seq
MIRT2500349	hsa-miR-5095	CLIP-seq
MIRT2500350	hsa-miR-519a	CLIP-seq
MIRT2500351	hsa-miR-519b-3p	CLIP-seq
MIRT2500352	hsa-miR-519c-3p	CLIP-seq
MIRT2500353	hsa-miR-520a-3p	CLIP-seq
MIRT2500354	hsa-miR-520b	CLIP-seq
MIRT2500355	hsa-miR-520c-3p	CLIP-seq
MIRT2500356	hsa-miR-520d-3p	CLIP-seq
MIRT2500357	hsa-miR-520e	CLIP-seq
MIRT2500358	hsa-miR-544	CLIP-seq
MIRT2500359	hsa-miR-548an	CLIP-seq
MIRT2500360	hsa-miR-548c-3p	CLIP-seq
MIRT2500361	hsa-miR-549	CLIP-seq
MIRT2500362	hsa-miR-555	CLIP-seq
MIRT2500363	hsa-miR-600	CLIP-seq
MIRT2500364	hsa-miR-615-5p	CLIP-seq
MIRT2500365	hsa-miR-641	CLIP-seq
MIRT2500302	hsa-miR-183	CLIP-seq
MIRT2500303	hsa-miR-22	CLIP-seq
MIRT1546344	hsa-miR-2276	CLIP-seq
MIRT2500304	hsa-miR-302a	CLIP-seq
MIRT2500305	hsa-miR-302b	CLIP-seq
MIRT2500306	hsa-miR-302c	CLIP-seq
MIRT2500307	hsa-miR-302d	CLIP-seq
MIRT2500308	hsa-miR-302e	CLIP-seq
MIRT2197079	hsa-miR-3152-5p	CLIP-seq
MIRT2500310	hsa-miR-3163	CLIP-seq
MIRT2500311	hsa-miR-3170	CLIP-seq
MIRT2500312	hsa-miR-3171	CLIP-seq
MIRT2500313	hsa-miR-3189-3p	CLIP-seq
MIRT2500314	hsa-miR-3617	CLIP-seq
MIRT2500316	hsa-miR-3654	CLIP-seq
MIRT2500317	hsa-miR-3662	CLIP-seq
MIRT2500318	hsa-miR-3668	CLIP-seq
MIRT2500320	hsa-miR-372	CLIP-seq
MIRT2500321	hsa-miR-373	CLIP-seq
MIRT2500322	hsa-miR-378	CLIP-seq
MIRT2500323	hsa-miR-378b	CLIP-seq
MIRT2500324	hsa-miR-378c	CLIP-seq
MIRT2500325	hsa-miR-378d	CLIP-seq
MIRT2500326	hsa-miR-378e	CLIP-seq
MIRT2500327	hsa-miR-378f	CLIP-seq
MIRT2500328	hsa-miR-378h	CLIP-seq
MIRT2500329	hsa-miR-378i	CLIP-seq
MIRT2500330	hsa-miR-422a	CLIP-seq
MIRT2500331	hsa-miR-4290	CLIP-seq
MIRT2500334	hsa-miR-4502	CLIP-seq
MIRT2500335	hsa-miR-4520a-5p	CLIP-seq
MIRT2500336	hsa-miR-4520b-5p	CLIP-seq
MIRT2500337	hsa-miR-4522	CLIP-seq
MIRT2500338	hsa-miR-4655-3p	CLIP-seq
MIRT2500340	hsa-miR-4684-5p	CLIP-seq
MIRT2500341	hsa-miR-4696	CLIP-seq
MIRT2500342	hsa-miR-4718	CLIP-seq
MIRT2500343	hsa-miR-4738-3p	CLIP-seq
MIRT2500345	hsa-miR-4772-3p	CLIP-seq
MIRT2197104	hsa-miR-4774-3p	CLIP-seq
MIRT2500347	hsa-miR-4796-5p	CLIP-seq
MIRT2500349	hsa-miR-5095	CLIP-seq
MIRT2500350	hsa-miR-519a	CLIP-seq
MIRT2500351	hsa-miR-519b-3p	CLIP-seq
MIRT2500352	hsa-miR-519c-3p	CLIP-seq
MIRT2500353	hsa-miR-520a-3p	CLIP-seq
MIRT2500354	hsa-miR-520b	CLIP-seq
MIRT2500355	hsa-miR-520c-3p	CLIP-seq
MIRT2500356	hsa-miR-520d-3p	CLIP-seq
MIRT2500357	hsa-miR-520e	CLIP-seq
MIRT2500358	hsa-miR-544	CLIP-seq
MIRT2500361	hsa-miR-549	CLIP-seq
MIRT2500362	hsa-miR-555	CLIP-seq
MIRT2500363	hsa-miR-600	CLIP-seq
MIRT2500364	hsa-miR-615-5p	CLIP-seq
MIRT2500365	hsa-miR-641	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24947832, 29513927, 32296183
GO:0005519	Function	Cytoskeletal regulatory protein binding	TAS	11035016
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0007165	Process	Signal transduction	TAS	11035016
GO:0007266	Process	Rho protein signal transduction	IBA
GO:0008360	Process	Regulation of cell shape	IBA
GO:0008360	Process	Regulation of cell shape	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	IBA
GO:0031267	Function	Small GTPase binding	IBA
GO:0031274	Process	Positive regulation of pseudopodium assembly	IBA

Other IDs

• MIM: 606133
• HGNC: 16943
• e!Ensembl: ENSG00000163171

Protein

• UniProt ID: Q9UKI2
• Protein name: Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein)
• Protein function: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00786	PBD	30 → 86	P21-Rho-binding domain	Domain
  PF14957	BORG_CEP	102 → 253	Cdc42 effector	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the heart and weakly in the brain. {ECO:0000269|PubMed:10490598}.
• Sequence:

  MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQ
  GNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALML
  PLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQ
  SSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGP
  SLLDEVLNVMDKNK

• Sequence length: 254

Pathways

Reactome:

MAPK6/MAPK4 signaling