Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10576
Gene name Gene Name - the full gene name approved by the HGNC.	Chaperonin containing TCP1 subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CCT2
Synonyms (NCBI Gene) Gene synonyms aliases	99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q15
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different p

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021019	hsa-miR-155-5p	Proteomics	18668040
MIRT041339	hsa-miR-193b-3p	CLASH	23622248
MIRT066727	hsa-miR-3646	PAR-CLIP	20371350
MIRT459841	hsa-miR-5700	PAR-CLIP	20371350
MIRT066720	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT066729	hsa-miR-5680	PAR-CLIP	20371350
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	20371350
MIRT066722	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT021019	hsa-miR-155-5p	PAR-CLIP	20371350
MIRT066727	hsa-miR-3646	PAR-CLIP	20371350
MIRT459841	hsa-miR-5700	PAR-CLIP	20371350
MIRT066720	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT066729	hsa-miR-5680	PAR-CLIP	20371350
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	20371350
MIRT066722	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT021019	hsa-miR-155-5p	PAR-CLIP	20371350
MIRT066728	hsa-miR-3671	PAR-CLIP	20371350
MIRT066724	hsa-miR-607	PAR-CLIP	20371350
MIRT066727	hsa-miR-3646	PAR-CLIP	20371350
MIRT459841	hsa-miR-5700	PAR-CLIP	20371350
MIRT066720	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT066729	hsa-miR-5680	PAR-CLIP	20371350
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	20371350
MIRT066722	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT021019	hsa-miR-155-5p	PAR-CLIP	20371350
MIRT066727	hsa-miR-3646	PAR-CLIP	23446348
MIRT459841	hsa-miR-5700	PAR-CLIP	23446348
MIRT066720	hsa-miR-144-3p	PAR-CLIP	23446348
MIRT066729	hsa-miR-5680	PAR-CLIP	23446348
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	23446348
MIRT066722	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT021019	hsa-miR-155-5p	PAR-CLIP	23446348
MIRT066727	hsa-miR-3646	PAR-CLIP	23592263
MIRT459841	hsa-miR-5700	PAR-CLIP	23592263
MIRT066720	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT066729	hsa-miR-5680	PAR-CLIP	23592263
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	23592263
MIRT066722	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT021019	hsa-miR-155-5p	PAR-CLIP	23592263
MIRT066728	hsa-miR-3671	PAR-CLIP	23592263
MIRT066724	hsa-miR-607	PAR-CLIP	23592263
MIRT066727	hsa-miR-3646	PAR-CLIP	20371350
MIRT459841	hsa-miR-5700	PAR-CLIP	20371350
MIRT066720	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT066729	hsa-miR-5680	PAR-CLIP	20371350
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	20371350
MIRT066722	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT021019	hsa-miR-155-5p	PAR-CLIP	20371350
MIRT066727	hsa-miR-3646	PAR-CLIP	20371350
MIRT459841	hsa-miR-5700	PAR-CLIP	20371350
MIRT066720	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT066729	hsa-miR-5680	PAR-CLIP	20371350
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	20371350
MIRT066722	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT021019	hsa-miR-155-5p	PAR-CLIP	20371350
MIRT066728	hsa-miR-3671	PAR-CLIP	20371350
MIRT066724	hsa-miR-607	PAR-CLIP	20371350
MIRT066727	hsa-miR-3646	PAR-CLIP	20371350
MIRT459841	hsa-miR-5700	PAR-CLIP	20371350
MIRT066720	hsa-miR-144-3p	PAR-CLIP	20371350
MIRT066729	hsa-miR-5680	PAR-CLIP	20371350
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	20371350
MIRT066722	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT021019	hsa-miR-155-5p	PAR-CLIP	20371350
MIRT066727	hsa-miR-3646	PAR-CLIP	23446348
MIRT459841	hsa-miR-5700	PAR-CLIP	23446348
MIRT066720	hsa-miR-144-3p	PAR-CLIP	23446348
MIRT066729	hsa-miR-5680	PAR-CLIP	23446348
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	23446348
MIRT066722	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT021019	hsa-miR-155-5p	PAR-CLIP	23446348
MIRT066727	hsa-miR-3646	PAR-CLIP	23592263
MIRT459841	hsa-miR-5700	PAR-CLIP	23592263
MIRT066720	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT066729	hsa-miR-5680	PAR-CLIP	23592263
MIRT459840	hsa-miR-4712-3p	PAR-CLIP	23592263
MIRT066722	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT021019	hsa-miR-155-5p	PAR-CLIP	23592263
MIRT066728	hsa-miR-3671	PAR-CLIP	23592263
MIRT066724	hsa-miR-607	PAR-CLIP	23592263
MIRT873339	hsa-miR-144	CLIP-seq
MIRT873340	hsa-miR-155	CLIP-seq
MIRT873341	hsa-miR-369-5p	CLIP-seq
MIRT873342	hsa-miR-4738-3p	CLIP-seq
MIRT873343	hsa-miR-539	CLIP-seq
MIRT873344	hsa-miR-582-3p	CLIP-seq
MIRT873345	hsa-miR-297	CLIP-seq
MIRT873346	hsa-miR-3148	CLIP-seq
MIRT873347	hsa-miR-3149	CLIP-seq
MIRT873348	hsa-miR-3662	CLIP-seq
MIRT873349	hsa-miR-3688-3p	CLIP-seq
MIRT873341	hsa-miR-369-5p	CLIP-seq
MIRT873350	hsa-miR-425	CLIP-seq
MIRT873351	hsa-miR-4462	CLIP-seq
MIRT873342	hsa-miR-4738-3p	CLIP-seq
MIRT873352	hsa-miR-548al	CLIP-seq
MIRT873344	hsa-miR-582-3p	CLIP-seq
MIRT1959123	hsa-miR-3974	CLIP-seq
MIRT1959124	hsa-miR-4506	CLIP-seq
MIRT1959125	hsa-miR-493	CLIP-seq
MIRT1959126	hsa-miR-518a-3p	CLIP-seq
MIRT1959127	hsa-miR-518b	CLIP-seq
MIRT1959128	hsa-miR-518c	CLIP-seq
MIRT1959129	hsa-miR-518d-3p	CLIP-seq
MIRT1959130	hsa-miR-518f	CLIP-seq
MIRT2499125	hsa-miR-3684	CLIP-seq
MIRT2499126	hsa-miR-3692	CLIP-seq
MIRT1959123	hsa-miR-3974	CLIP-seq
MIRT873351	hsa-miR-4462	CLIP-seq
MIRT2499127	hsa-miR-4477b	CLIP-seq
MIRT1959124	hsa-miR-4506	CLIP-seq
MIRT873342	hsa-miR-4738-3p	CLIP-seq
MIRT2499128	hsa-miR-4778-3p	CLIP-seq
MIRT1959125	hsa-miR-493	CLIP-seq
MIRT1959126	hsa-miR-518a-3p	CLIP-seq
MIRT1959127	hsa-miR-518b	CLIP-seq
MIRT1959128	hsa-miR-518c	CLIP-seq
MIRT1959129	hsa-miR-518d-3p	CLIP-seq
MIRT1959130	hsa-miR-518f	CLIP-seq
MIRT873352	hsa-miR-548al	CLIP-seq
MIRT2499129	hsa-miR-633	CLIP-seq
MIRT2499125	hsa-miR-3684	CLIP-seq
MIRT2499126	hsa-miR-3692	CLIP-seq
MIRT1959123	hsa-miR-3974	CLIP-seq
MIRT873351	hsa-miR-4462	CLIP-seq
MIRT2499127	hsa-miR-4477b	CLIP-seq
MIRT1959124	hsa-miR-4506	CLIP-seq
MIRT2499128	hsa-miR-4778-3p	CLIP-seq
MIRT1959125	hsa-miR-493	CLIP-seq
MIRT1959126	hsa-miR-518a-3p	CLIP-seq
MIRT1959127	hsa-miR-518b	CLIP-seq
MIRT1959128	hsa-miR-518c	CLIP-seq
MIRT1959129	hsa-miR-518d-3p	CLIP-seq
MIRT1959130	hsa-miR-518f	CLIP-seq
MIRT873352	hsa-miR-548al	CLIP-seq
MIRT2499129	hsa-miR-633	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002199	Component	Zona pellucida receptor complex	IEA
GO:0005515	Function	Protein binding	IPI	14532270, 16085932, 16097032, 17429077, 20080638, 22500027, 25416956, 25467444, 27353360, 28514442, 30021884, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	NAS	11532003
GO:0005829	Component	Cytosol	TAS
GO:0005832	Component	Chaperonin-containing T-complex	IBA	21873635
GO:0005832	Component	Chaperonin-containing T-complex	IDA	23011926, 25467444, 30955883
GO:0005874	Component	Microtubule	IDA	21525035
GO:0006457	Process	Protein folding	IBA	21873635
GO:0006457	Process	Protein folding	IDA	30955883
GO:0006457	Process	Protein folding	NAS	11532003
GO:0006457	Process	Protein folding	TAS
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	21753002
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IMP	25467444
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0044183	Function	Protein folding chaperone	IDA	25467444, 30955883
GO:0044297	Component	Cell body	IEA
GO:0050821	Process	Protein stabilization	IMP	25467444
GO:0051082	Function	Unfolded protein binding	IBA	21873635
GO:0051082	Function	Unfolded protein binding	NAS	11532003
GO:0051086	Process	Chaperone mediated protein folding independent of cofactor	IMP	25467444
GO:0051131	Process	Chaperone-mediated protein complex assembly	IMP	20080638
GO:0051973	Process	Positive regulation of telomerase activity	IMP	25467444
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0090666	Process	ScaRNA localization to Cajal body	IMP	25467444
GO:1901998	Process	Toxin transport	IEA
GO:1904851	Process	Positive regulation of establishment of protein localization to telomere	IMP	25467444
GO:1904871	Process	Positive regulation of protein localization to Cajal body	HMP	25467444
GO:1904874	Process	Positive regulation of telomerase RNA localization to Cajal body	HMP	25467444
GO:1904874	Process	Positive regulation of telomerase RNA localization to Cajal body	IMP	25467444

MIM	HGNC	e!Ensembl
605139	1615	ENSG00000166226

Protein

UniProt ID

P78371

Protein name

T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)

Protein function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TR

PDB

6NR8 , 6NR9 , 6NRA , 6NRB , 6NRC , 6NRD , 6QB8 , 7LUM , 7LUP , 7NVL , 7NVM , 7NVN , 7NVO , 7TRG , 7TTN , 7TTT , 7TUB , 7WU7 , 7WZ3 , 7X0A , 7X0S , 7X0V , 7X3J , 7X3U , 7X6Q , 7X7Y , 8HKI , 8I1U , 8I9U , 8IB8 , 8SFE , 8SFF , 8SG8 , 8SG9 , 8SGC , 8SGL , 8SGQ , 8SH9 , 8SHA , 8SHD , 8SHE , 8SHF , 8SHG , 8SHL , 8SHN , 8SHO , 8SHP , 8SHQ , 8SHT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00118	Cpn60_TCP1	35 → 525	TCP-1/cpn60 chaperonin family	Family

Sequence

MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDAS
LMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKK
IHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFT
KLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIA
NTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYP
EQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLI
HFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHA
VTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDM
REGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC

Sequence length

535

Interactions

View interactions

	Reactome
			Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	18924182

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Myocardial infarction	Myocardial Infarction		21211798	ClinVar

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Stimulate	23782473
Alzheimer Disease	Associate	31984950
Atypical Squamous Cells of the Cervix	Associate	23782473
Breast Neoplasms	Stimulate	27012814
Breast Neoplasms	Associate	31101846, 38358781
Carcinoma Adenosquamous	Associate	23782473
Carcinoma Ductal	Associate	27012814
Carcinoma Hepatocellular	Stimulate	11795471
Colonic Neoplasms	Stimulate	11795471
Colorectal Neoplasms	Associate	11795471
COVID 19	Associate	35390032
Gallbladder Neoplasms	Associate	23782473
Graves Ophthalmopathy	Associate	36076300
Hemoglobin SC Disease	Associate	23782473
Hirschsprung Disease	Associate	29483666
Hypertensive Retinopathy	Associate	37644231
Leber Congenital Amaurosis	Associate	37644231
Lymphatic Metastasis	Stimulate	23782473
Multiple Myeloma	Associate	32410217
Neoplasms	Associate	11795471, 23782473

CCT2 (chaperonin containing TCP1 subunit 2)