Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10552
Gene name Gene Name - the full gene name approved by the HGNC.	Actin related protein 2/3 complex subunit 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARPC1A
Synonyms (NCBI Gene) Gene synonyms aliases	Arc40, HEL-68, HEL-S-307, SOP2Hs, SOP2L
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they bo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT046551	hsa-let-7i-5p	CLASH	23622248
MIRT038032	hsa-miR-423-5p	CLASH	23622248
MIRT799641	hsa-miR-1	CLIP-seq
MIRT799642	hsa-miR-1256	CLIP-seq
MIRT799643	hsa-miR-1276	CLIP-seq
MIRT799644	hsa-miR-133a	CLIP-seq
MIRT799645	hsa-miR-133b	CLIP-seq
MIRT799646	hsa-miR-181a	CLIP-seq
MIRT799647	hsa-miR-181b	CLIP-seq
MIRT799648	hsa-miR-181c	CLIP-seq
MIRT799649	hsa-miR-181d	CLIP-seq
MIRT799650	hsa-miR-190	CLIP-seq
MIRT799651	hsa-miR-190b	CLIP-seq
MIRT799652	hsa-miR-206	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799654	hsa-miR-3591-5p	CLIP-seq
MIRT799655	hsa-miR-3613-3p	CLIP-seq
MIRT799656	hsa-miR-3673	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT799658	hsa-miR-3689a-5p	CLIP-seq
MIRT799659	hsa-miR-3689b	CLIP-seq
MIRT799660	hsa-miR-3689e	CLIP-seq
MIRT799661	hsa-miR-3689f	CLIP-seq
MIRT799662	hsa-miR-4262	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT799664	hsa-miR-4276	CLIP-seq
MIRT799665	hsa-miR-4277	CLIP-seq
MIRT799666	hsa-miR-4302	CLIP-seq
MIRT799667	hsa-miR-4311	CLIP-seq
MIRT799668	hsa-miR-4504	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT799670	hsa-miR-495	CLIP-seq
MIRT799671	hsa-miR-542-3p	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799673	hsa-miR-548ac	CLIP-seq
MIRT799674	hsa-miR-548d-3p	CLIP-seq
MIRT799675	hsa-miR-548z	CLIP-seq
MIRT799676	hsa-miR-583	CLIP-seq
MIRT799677	hsa-miR-587	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT799679	hsa-miR-606	CLIP-seq
MIRT799680	hsa-miR-613	CLIP-seq
MIRT799681	hsa-miR-648	CLIP-seq
MIRT799682	hsa-miR-9	CLIP-seq
MIRT799683	hsa-miR-10a	CLIP-seq
MIRT799684	hsa-miR-10b	CLIP-seq
MIRT799646	hsa-miR-181a	CLIP-seq
MIRT799647	hsa-miR-181b	CLIP-seq
MIRT799648	hsa-miR-181c	CLIP-seq
MIRT799649	hsa-miR-181d	CLIP-seq
MIRT799685	hsa-miR-197	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799686	hsa-miR-339-5p	CLIP-seq
MIRT799687	hsa-miR-3620	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT799662	hsa-miR-4262	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT799665	hsa-miR-4277	CLIP-seq
MIRT799688	hsa-miR-4287	CLIP-seq
MIRT799689	hsa-miR-4421	CLIP-seq
MIRT799690	hsa-miR-4469	CLIP-seq
MIRT799691	hsa-miR-4685-3p	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT799692	hsa-miR-5096	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT799641	hsa-miR-1	CLIP-seq
MIRT799642	hsa-miR-1256	CLIP-seq
MIRT799643	hsa-miR-1276	CLIP-seq
MIRT799644	hsa-miR-133a	CLIP-seq
MIRT799645	hsa-miR-133b	CLIP-seq
MIRT799646	hsa-miR-181a	CLIP-seq
MIRT799647	hsa-miR-181b	CLIP-seq
MIRT799648	hsa-miR-181c	CLIP-seq
MIRT799649	hsa-miR-181d	CLIP-seq
MIRT799650	hsa-miR-190	CLIP-seq
MIRT799651	hsa-miR-190b	CLIP-seq
MIRT799685	hsa-miR-197	CLIP-seq
MIRT799652	hsa-miR-206	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799656	hsa-miR-3673	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT799658	hsa-miR-3689a-5p	CLIP-seq
MIRT799659	hsa-miR-3689b	CLIP-seq
MIRT799660	hsa-miR-3689e	CLIP-seq
MIRT799661	hsa-miR-3689f	CLIP-seq
MIRT799662	hsa-miR-4262	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT799664	hsa-miR-4276	CLIP-seq
MIRT799665	hsa-miR-4277	CLIP-seq
MIRT799688	hsa-miR-4287	CLIP-seq
MIRT799667	hsa-miR-4311	CLIP-seq
MIRT799690	hsa-miR-4469	CLIP-seq
MIRT799691	hsa-miR-4685-3p	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT799692	hsa-miR-5096	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799676	hsa-miR-583	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT799679	hsa-miR-606	CLIP-seq
MIRT799680	hsa-miR-613	CLIP-seq
MIRT799682	hsa-miR-9	CLIP-seq
MIRT2176097	hsa-miR-1227	CLIP-seq
MIRT2176098	hsa-miR-1238	CLIP-seq
MIRT799653	hsa-miR-3138	CLIP-seq
MIRT799657	hsa-miR-3681	CLIP-seq
MIRT2176099	hsa-miR-4260	CLIP-seq
MIRT799663	hsa-miR-4272	CLIP-seq
MIRT2176100	hsa-miR-4283	CLIP-seq
MIRT2176101	hsa-miR-4489	CLIP-seq
MIRT2176102	hsa-miR-4492	CLIP-seq
MIRT2176103	hsa-miR-4498	CLIP-seq
MIRT799669	hsa-miR-4775	CLIP-seq
MIRT2176104	hsa-miR-516a-3p	CLIP-seq
MIRT799672	hsa-miR-548aa	CLIP-seq
MIRT799678	hsa-miR-590-3p	CLIP-seq
MIRT2176105	hsa-miR-762	CLIP-seq
MIRT2479463	hsa-miR-1193	CLIP-seq
MIRT2176097	hsa-miR-1227	CLIP-seq
MIRT2176098	hsa-miR-1238	CLIP-seq
MIRT799642	hsa-miR-1256	CLIP-seq
MIRT2479464	hsa-miR-1287	CLIP-seq
MIRT799650	hsa-miR-190	CLIP-seq
MIRT799651	hsa-miR-190b	CLIP-seq
MIRT2479465	hsa-miR-2467-5p	CLIP-seq
MIRT2479466	hsa-miR-3135b	CLIP-seq
MIRT2479467	hsa-miR-3189-3p	CLIP-seq
MIRT799658	hsa-miR-3689a-5p	CLIP-seq
MIRT799659	hsa-miR-3689b	CLIP-seq
MIRT799660	hsa-miR-3689e	CLIP-seq
MIRT799661	hsa-miR-3689f	CLIP-seq
MIRT2176099	hsa-miR-4260	CLIP-seq
MIRT799664	hsa-miR-4276	CLIP-seq
MIRT2176100	hsa-miR-4283	CLIP-seq
MIRT2479468	hsa-miR-4284	CLIP-seq
MIRT799666	hsa-miR-4302	CLIP-seq
MIRT2176101	hsa-miR-4489	CLIP-seq
MIRT2176102	hsa-miR-4492	CLIP-seq
MIRT2176103	hsa-miR-4498	CLIP-seq
MIRT2479469	hsa-miR-4730	CLIP-seq
MIRT2479470	hsa-miR-502-5p	CLIP-seq
MIRT2479471	hsa-miR-512-5p	CLIP-seq
MIRT2176104	hsa-miR-516a-3p	CLIP-seq
MIRT2479472	hsa-miR-658	CLIP-seq
MIRT2176105	hsa-miR-762	CLIP-seq
MIRT2479463	hsa-miR-1193	CLIP-seq
MIRT2479464	hsa-miR-1287	CLIP-seq
MIRT2479465	hsa-miR-2467-5p	CLIP-seq
MIRT2479466	hsa-miR-3135b	CLIP-seq
MIRT2479468	hsa-miR-4284	CLIP-seq
MIRT2479469	hsa-miR-4730	CLIP-seq
MIRT2479472	hsa-miR-658	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	TAS	8978670
GO:0005634	Component	Nucleus	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005885	Component	Arp2/3 protein complex	IBA	21873635
GO:0005885	Component	Arp2/3 protein complex	ISS
GO:0015629	Component	Actin cytoskeleton	TAS	8978670
GO:0030036	Process	Actin cytoskeleton organization	TAS	8978670
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA	21873635
GO:0035861	Component	Site of double-strand break	ISS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0051015	Function	Actin filament binding	IBA	21873635
GO:0061024	Process	Membrane organization	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
604220	703	ENSG00000241685

Protein

UniProt ID

Q92747

Protein name

Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)

Protein function

Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000305|Pub

PDB

6YW7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	42 → 80	WD domain, G-beta repeat	Repeat
PF00400	WD40	132 → 170	WD domain, G-beta repeat	Repeat

Sequence

MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW
APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI
SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP
ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS
TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAM
ERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTL
ESSIQGLRIM

Sequence length

370

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Tight junction Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection		Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Coronary syndrome	Acute Coronary Syndrome		25935875	ClinVar

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	35441736
Arthritis Rheumatoid	Associate	28712091
Carcinoma Hepatocellular	Stimulate	33960941
Carcinoma Non Small Cell Lung	Associate	39867911
Lymphatic Metastasis	Associate	32130760
Neoplasms	Associate	32130760, 39867911

ARPC1A (actin related protein 2/3 complex subunit 1A)