AGR2 (anterior gradient 2, protein disulphide isomerase family member)

Gene

• Entrez ID: 10551
• Gene name: Anterior gradient 2, protein disulphide isomerase family member
• Gene symbol: AGR2
• Synonyms (NCBI Gene): AG-2, AG2, GOB-4, HAG-2, HEL-S-116, HPC8, PDIA17, RIFTD, XAG-2
• Disease Acronyms (UniProt): RIFTD
• Chromosome: 7
• Chromosome location: 7p21.1
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically ac

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004183	hsa-miR-197-3p	Microarray	16822819
MIRT018401	hsa-miR-335-5p	Microarray	18185580
MIRT737361	hsa-miR-342-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	32493835
MIRT772996	hsa-miR-194	CLIP-seq
MIRT772997	hsa-miR-2115	CLIP-seq
MIRT772998	hsa-miR-3143	CLIP-seq
MIRT772999	hsa-miR-3613-5p	CLIP-seq
MIRT773000	hsa-miR-4302	CLIP-seq
MIRT773001	hsa-miR-516a-3p	CLIP-seq
MIRT773002	hsa-miR-543	CLIP-seq
MIRT772996	hsa-miR-194	CLIP-seq
MIRT1928195	hsa-miR-24	CLIP-seq
MIRT1928196	hsa-miR-2681	CLIP-seq
MIRT1928197	hsa-miR-300	CLIP-seq
MIRT1928198	hsa-miR-338-5p	CLIP-seq
MIRT772999	hsa-miR-3613-5p	CLIP-seq
MIRT1928199	hsa-miR-381	CLIP-seq
MIRT1928200	hsa-miR-4284	CLIP-seq
MIRT1928201	hsa-miR-4666-3p	CLIP-seq
MIRT2168922	hsa-miR-1229	CLIP-seq
MIRT2168923	hsa-miR-1297	CLIP-seq
MIRT2168924	hsa-miR-1324	CLIP-seq
MIRT772996	hsa-miR-194	CLIP-seq
MIRT772997	hsa-miR-2115	CLIP-seq
MIRT1928195	hsa-miR-24	CLIP-seq
MIRT1928196	hsa-miR-2681	CLIP-seq
MIRT2168925	hsa-miR-26a	CLIP-seq
MIRT2168926	hsa-miR-26b	CLIP-seq
MIRT772998	hsa-miR-3143	CLIP-seq
MIRT2168927	hsa-miR-3182	CLIP-seq
MIRT772999	hsa-miR-3613-5p	CLIP-seq
MIRT2168928	hsa-miR-3660	CLIP-seq
MIRT2168929	hsa-miR-3692	CLIP-seq
MIRT2168930	hsa-miR-3922-5p	CLIP-seq
MIRT1928200	hsa-miR-4284	CLIP-seq
MIRT773000	hsa-miR-4302	CLIP-seq
MIRT2168931	hsa-miR-4465	CLIP-seq
MIRT2168932	hsa-miR-4526	CLIP-seq
MIRT2168933	hsa-miR-4659a-3p	CLIP-seq
MIRT2168934	hsa-miR-4659b-3p	CLIP-seq
MIRT2168935	hsa-miR-4676-5p	CLIP-seq
MIRT2168936	hsa-miR-4704-5p	CLIP-seq
MIRT2168937	hsa-miR-4778-3p	CLIP-seq
MIRT2168938	hsa-miR-498	CLIP-seq
MIRT2168939	hsa-miR-513c	CLIP-seq
MIRT2168940	hsa-miR-514b-5p	CLIP-seq
MIRT773001	hsa-miR-516a-3p	CLIP-seq
MIRT773002	hsa-miR-543	CLIP-seq
MIRT2168941	hsa-miR-575	CLIP-seq
MIRT2168942	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXA1	Unknown	16222343
FOXA2	Unknown	16222343
PA2G4	Activation	20048076
SPDEF	Activation	19786015

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002162	Function	Dystroglycan binding	IBA	21873635
GO:0002162	Function	Dystroglycan binding	IDA	12592373
GO:0005154	Function	Epidermal growth factor receptor binding	IPI	25666625
GO:0005515	Function	Protein binding	IPI	12592373, 16189514, 19359471, 23220234, 25416956, 25910212, 32296183, 32814053
GO:0005615	Component	Extracellular space	IDA	22184114, 24251762
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IMP	22184114
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0010628	Process	Positive regulation of gene expression	IMP	22184114
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IMP	23274113
GO:0034976	Process	Response to endoplasmic reticulum stress	IMP	25666625
GO:0042802	Function	Identical protein binding	IPI	23220234, 23274113
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	IMP	25666625
GO:0048546	Process	Digestive tract morphogenesis	ISS
GO:0048639	Process	Positive regulation of developmental growth	ISS
GO:0060548	Process	Negative regulation of cell death	IBA	21873635
GO:0060548	Process	Negative regulation of cell death	IMP	23220234
GO:0070254	Process	Mucus secretion	ISS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IMP	25666625
GO:1903896	Process	Positive regulation of IRE1-mediated unfolded protein response	IDA	23220234
GO:1903899	Process	Positive regulation of PERK-mediated unfolded protein response	IDA	23220234

Other IDs

• MIM: 606358
• HGNC: 328
• e!Ensembl: ENSG00000106541

Protein

• UniProt ID: O95994
• Protein name: Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)
• Protein function: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes
• PDB: 2LNS, 2LNT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13899	Thioredoxin_7	53 → 133		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis
• Sequence:

  MEKIPVSAFLLLVALSYTLARDTTVKPGAKKDTKDSRPKLPQTLSRGWGDQLIWTQTYEE
  ALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLVYETTDKHLSP
  DGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPADTALLLDNMKKALKLLKTEL

• Sequence length: 175

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	20531310
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	20531310
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	20531310
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	25237833, 17013881

Unknown
Disease term	Disease name	Evidence	References	Source
Diabetes	Diabetes			GWAS
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Stimulate	21144054
Adenocarcinoma	Associate	22605983, 22748473, 26894971, 33278424, 34911496, 35857928
Adenocarcinoma of Lung	Associate	22430137, 33684161, 36595821
Barrett Esophagus	Associate	21829465, 33491460
Biliary Tract Neoplasms	Associate	25186196
Brain Neoplasms	Associate	27100728
Breast Neoplasms	Associate	16551856, 16598187, 20847343, 24167368, 25186196, 25956506, 26079208, 26733232, 30665445, 32593213, 34092584, 34567804, 34913074, 36405393, 37568077
Breast Neoplasms	Stimulate	23029506
Calcinosis Cutis	Associate	26876500, 30295739
Calcinosis Cutis	Stimulate	36405393
Carcinogenesis	Associate	25186196, 32593213, 33413231, 35857928, 36593009
Carcinoma Hepatocellular	Stimulate	35013529
Carcinoma Hepatocellular	Associate	36003068
Carcinoma Non Small Cell Lung	Associate	26445321
Carcinoma Pancreatic Ductal	Associate	25418581, 36329620
Carcinoma Renal Cell	Associate	32593213, 36516496
Carcinoma Squamous Cell	Associate	22748473, 31752667
Chemotherapy Related Cognitive Impairment	Associate	34913074
Colitis Ulcerative	Associate	34055987
Colorectal Neoplasms	Associate	22089087, 22231555, 22605983, 39300184
Constriction Pathologic	Associate	33822017
Crohn Disease	Associate	28339048, 33822017
Cystic Fibrosis	Associate	34952832
Death	Associate	16598187
Diarrhea	Associate	34952832
Esophageal Squamous Cell Carcinoma	Associate	35962061, 36327302
Fibrolamellar hepatocellular carcinoma	Associate	18973922
Gastroesophageal Reflux	Associate	21829465
Gastrointestinal Neoplasms	Associate	18801625, 22089087
Genetic Diseases Inborn	Associate	34952832
Glioblastoma	Associate	26608373
Glioblastoma	Stimulate	36622190
Glut1 Deficiency Syndrome	Associate	34055987
Huntington Disease	Associate	25655581, 25947144
Hypoxia	Associate	26079208
Hypoxia Brain	Associate	32593213
Ileal Diseases	Associate	33822017
Inflammation	Stimulate	32593213
Lung Neoplasms	Associate	26445321, 33278424
Lymphatic Metastasis	Inhibit	32733958
Melanoma	Associate	37924160
Mouth Diseases	Associate	21144054
Mucositis	Inhibit	34055987
Nasal Polyps	Associate	32047813
Nasopharyngeal Carcinoma	Stimulate	24717913
Neoplasm Metastasis	Associate	16598187, 33413231, 34092584, 34913074, 34929376, 35857928, 36405393, 36595821
Neoplasms	Associate	12592373, 16551856, 16598187, 18801625, 21144054, 22089087, 22231555, 22605983, 25186196, 25237833, 25418581, 26445321, 26733232, 26876500, 26894971, 28810836, 30665445, 33278424, 33413231, 34911496, 34913074, 34929376, 35857928, 36327302, 36405393, 36595821
Neoplasms	Stimulate	20550709, 23029506, 36232621
Ovarian Diseases	Associate	21200134
Ovarian Neoplasms	Stimulate	21200134
Ovarian Neoplasms	Associate	31937926
Pancreatic Intraductal Neoplasms	Stimulate	20550709
Pancreatic Neoplasms	Stimulate	20550709, 36812168
Pancreatic Neoplasms	Associate	21653254, 25418581, 33413231, 36329620
Prostatic Neoplasms	Associate	20048076, 21144054, 25237833, 30295739, 37121942
Soft Tissue Injuries	Associate	23029506
Squamous Cell Carcinoma of Head and Neck	Associate	32733958
Stomach Neoplasms	Associate	21533548, 36593009
Thyroid Cancer Papillary	Associate	24976026
Thyroid Neoplasms	Associate	24976026
Triple Negative Breast Neoplasms	Associate	30146936, 36157217
Tuberculosis	Associate	25947144
Urethral Neoplasms	Associate	26894971
Urinary Bladder Neoplasms	Associate	26894971
Uterine Cervical Dysplasia	Stimulate	20550709, 25418581
Uterine Cervical Neoplasms	Associate	31436390