Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10544
Gene name Gene Name - the full gene name approved by the HGNC.	Protein C receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PROCR
Synonyms (NCBI Gene) Gene synonyms aliases	CCCA, CCD41, EPCR
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q11.22
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein

Show/Hide all(199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019919	hsa-miR-375	Microarray	20215506
MIRT023818	hsa-miR-1-3p	Proteomics	18668040
MIRT037191	hsa-miR-877-3p	CLASH	23622248
MIRT1265035	hsa-miR-181a	CLIP-seq
MIRT1265036	hsa-miR-181b	CLIP-seq
MIRT1265037	hsa-miR-181c	CLIP-seq
MIRT1265038	hsa-miR-181d	CLIP-seq
MIRT1265039	hsa-miR-361-5p	CLIP-seq
MIRT1265040	hsa-miR-4262	CLIP-seq
MIRT1265041	hsa-miR-4477a	CLIP-seq
MIRT1265042	hsa-miR-4494	CLIP-seq
MIRT1265043	hsa-miR-499a-5p	CLIP-seq
MIRT1265044	hsa-miR-543	CLIP-seq
MIRT1265045	hsa-miR-577	CLIP-seq
MIRT1265046	hsa-miR-656	CLIP-seq
MIRT1265047	hsa-miR-889	CLIP-seq
MIRT1556847	hsa-miR-3692	CLIP-seq
MIRT2077894	hsa-miR-1228	CLIP-seq
MIRT2077895	hsa-miR-1237	CLIP-seq
MIRT2077896	hsa-miR-1255a	CLIP-seq
MIRT2077897	hsa-miR-1255b	CLIP-seq
MIRT2077898	hsa-miR-219-5p	CLIP-seq
MIRT2077899	hsa-miR-329	CLIP-seq
MIRT2077900	hsa-miR-330-3p	CLIP-seq
MIRT2077901	hsa-miR-3613-5p	CLIP-seq
MIRT2077902	hsa-miR-362-3p	CLIP-seq
MIRT2077903	hsa-miR-3691-5p	CLIP-seq
MIRT2077904	hsa-miR-409-3p	CLIP-seq
MIRT2077905	hsa-miR-4291	CLIP-seq
MIRT2077906	hsa-miR-4422	CLIP-seq
MIRT2077907	hsa-miR-4445	CLIP-seq
MIRT2077908	hsa-miR-4752	CLIP-seq
MIRT2077909	hsa-miR-4760-3p	CLIP-seq
MIRT2077910	hsa-miR-4782-3p	CLIP-seq
MIRT2077911	hsa-miR-508-3p	CLIP-seq
MIRT2077912	hsa-miR-545	CLIP-seq
MIRT2077913	hsa-miR-619	CLIP-seq
MIRT2077914	hsa-miR-642b	CLIP-seq
MIRT2601300	hsa-miR-1202	CLIP-seq
MIRT2077894	hsa-miR-1228	CLIP-seq
MIRT2077895	hsa-miR-1237	CLIP-seq
MIRT2077896	hsa-miR-1255a	CLIP-seq
MIRT2077897	hsa-miR-1255b	CLIP-seq
MIRT2601301	hsa-miR-125a-3p	CLIP-seq
MIRT2601302	hsa-miR-128	CLIP-seq
MIRT2601303	hsa-miR-136	CLIP-seq
MIRT2601304	hsa-miR-149	CLIP-seq
MIRT2601305	hsa-miR-1913	CLIP-seq
MIRT2601306	hsa-miR-204	CLIP-seq
MIRT2601307	hsa-miR-211	CLIP-seq
MIRT2601308	hsa-miR-2110	CLIP-seq
MIRT2077898	hsa-miR-219-5p	CLIP-seq
MIRT2601309	hsa-miR-2392	CLIP-seq
MIRT2601310	hsa-miR-27a	CLIP-seq
MIRT2601311	hsa-miR-27b	CLIP-seq
MIRT2601312	hsa-miR-3064-5p	CLIP-seq
MIRT2601313	hsa-miR-3074-5p	CLIP-seq
MIRT2601314	hsa-miR-3120-5p	CLIP-seq
MIRT2601315	hsa-miR-3145-5p	CLIP-seq
MIRT2601316	hsa-miR-3150a-3p	CLIP-seq
MIRT2601317	hsa-miR-3175	CLIP-seq
MIRT2601318	hsa-miR-3189-5p	CLIP-seq
MIRT2601319	hsa-miR-3194-5p	CLIP-seq
MIRT2601320	hsa-miR-324-3p	CLIP-seq
MIRT2077899	hsa-miR-329	CLIP-seq
MIRT2601321	hsa-miR-3605-5p	CLIP-seq
MIRT2077901	hsa-miR-3613-5p	CLIP-seq
MIRT2077902	hsa-miR-362-3p	CLIP-seq
MIRT2077903	hsa-miR-3691-5p	CLIP-seq
MIRT1556847	hsa-miR-3692	CLIP-seq
MIRT2601322	hsa-miR-3934	CLIP-seq
MIRT2601323	hsa-miR-3972	CLIP-seq
MIRT2077904	hsa-miR-409-3p	CLIP-seq
MIRT2601324	hsa-miR-4259	CLIP-seq
MIRT2601325	hsa-miR-4294	CLIP-seq
MIRT2601326	hsa-miR-4299	CLIP-seq
MIRT2601327	hsa-miR-4443	CLIP-seq
MIRT2077907	hsa-miR-4445	CLIP-seq
MIRT2601328	hsa-miR-4446-5p	CLIP-seq
MIRT2601329	hsa-miR-4456	CLIP-seq
MIRT2601330	hsa-miR-4640-5p	CLIP-seq
MIRT2601331	hsa-miR-4694-5p	CLIP-seq
MIRT2601332	hsa-miR-4722-3p	CLIP-seq
MIRT2601333	hsa-miR-4726-5p	CLIP-seq
MIRT2601334	hsa-miR-4738-3p	CLIP-seq
MIRT2077908	hsa-miR-4752	CLIP-seq
MIRT2601335	hsa-miR-4755-5p	CLIP-seq
MIRT2601336	hsa-miR-4758-3p	CLIP-seq
MIRT2601337	hsa-miR-4778-5p	CLIP-seq
MIRT2601338	hsa-miR-4780	CLIP-seq
MIRT2077910	hsa-miR-4782-3p	CLIP-seq
MIRT2601339	hsa-miR-4794	CLIP-seq
MIRT2601340	hsa-miR-483-3p	CLIP-seq
MIRT2077911	hsa-miR-508-3p	CLIP-seq
MIRT2601341	hsa-miR-511	CLIP-seq
MIRT2601342	hsa-miR-513a-5p	CLIP-seq
MIRT2601343	hsa-miR-516a-3p	CLIP-seq
MIRT2601344	hsa-miR-548q	CLIP-seq
MIRT2601345	hsa-miR-614	CLIP-seq
MIRT2077913	hsa-miR-619	CLIP-seq
MIRT2601346	hsa-miR-623	CLIP-seq
MIRT2077914	hsa-miR-642b	CLIP-seq
MIRT2601347	hsa-miR-659	CLIP-seq
MIRT2601348	hsa-miR-668	CLIP-seq
MIRT2601349	hsa-miR-764	CLIP-seq
MIRT2601350	hsa-miR-765	CLIP-seq
MIRT2601351	hsa-miR-885-5p	CLIP-seq
MIRT2601352	hsa-miR-887	CLIP-seq
MIRT2601353	hsa-miR-9	CLIP-seq
MIRT2601354	hsa-miR-939	CLIP-seq
MIRT2601300	hsa-miR-1202	CLIP-seq
MIRT2077894	hsa-miR-1228	CLIP-seq
MIRT2077895	hsa-miR-1237	CLIP-seq
MIRT2077896	hsa-miR-1255a	CLIP-seq
MIRT2077897	hsa-miR-1255b	CLIP-seq
MIRT2601301	hsa-miR-125a-3p	CLIP-seq
MIRT2601302	hsa-miR-128	CLIP-seq
MIRT2688654	hsa-miR-1290	CLIP-seq
MIRT2601303	hsa-miR-136	CLIP-seq
MIRT2601304	hsa-miR-149	CLIP-seq
MIRT2601305	hsa-miR-1913	CLIP-seq
MIRT2601306	hsa-miR-204	CLIP-seq
MIRT2601307	hsa-miR-211	CLIP-seq
MIRT2601308	hsa-miR-2110	CLIP-seq
MIRT2077898	hsa-miR-219-5p	CLIP-seq
MIRT2601309	hsa-miR-2392	CLIP-seq
MIRT2601310	hsa-miR-27a	CLIP-seq
MIRT2601311	hsa-miR-27b	CLIP-seq
MIRT2601312	hsa-miR-3064-5p	CLIP-seq
MIRT2688655	hsa-miR-3074-3p	CLIP-seq
MIRT2601313	hsa-miR-3074-5p	CLIP-seq
MIRT2601314	hsa-miR-3120-5p	CLIP-seq
MIRT2688656	hsa-miR-3127-3p	CLIP-seq
MIRT2601315	hsa-miR-3145-5p	CLIP-seq
MIRT2601316	hsa-miR-3150a-3p	CLIP-seq
MIRT2688657	hsa-miR-3160-3p	CLIP-seq
MIRT2688658	hsa-miR-3167	CLIP-seq
MIRT2601317	hsa-miR-3175	CLIP-seq
MIRT2688659	hsa-miR-3184	CLIP-seq
MIRT2601318	hsa-miR-3189-5p	CLIP-seq
MIRT2601319	hsa-miR-3194-5p	CLIP-seq
MIRT2601320	hsa-miR-324-3p	CLIP-seq
MIRT2077899	hsa-miR-329	CLIP-seq
MIRT2601321	hsa-miR-3605-5p	CLIP-seq
MIRT2077901	hsa-miR-3613-5p	CLIP-seq
MIRT2077902	hsa-miR-362-3p	CLIP-seq
MIRT2688660	hsa-miR-3676	CLIP-seq
MIRT2688661	hsa-miR-3682-5p	CLIP-seq
MIRT2077903	hsa-miR-3691-5p	CLIP-seq
MIRT1556847	hsa-miR-3692	CLIP-seq
MIRT2601322	hsa-miR-3934	CLIP-seq
MIRT2601323	hsa-miR-3972	CLIP-seq
MIRT2077904	hsa-miR-409-3p	CLIP-seq
MIRT2688662	hsa-miR-423-5p	CLIP-seq
MIRT2601324	hsa-miR-4259	CLIP-seq
MIRT2601325	hsa-miR-4294	CLIP-seq
MIRT2601326	hsa-miR-4299	CLIP-seq
MIRT2688663	hsa-miR-4303	CLIP-seq
MIRT2601327	hsa-miR-4443	CLIP-seq
MIRT2077907	hsa-miR-4445	CLIP-seq
MIRT2601328	hsa-miR-4446-5p	CLIP-seq
MIRT2601329	hsa-miR-4456	CLIP-seq
MIRT2688664	hsa-miR-4487	CLIP-seq
MIRT2601330	hsa-miR-4640-5p	CLIP-seq
MIRT2688665	hsa-miR-4649-3p	CLIP-seq
MIRT2688666	hsa-miR-4662a-3p	CLIP-seq
MIRT2601331	hsa-miR-4694-5p	CLIP-seq
MIRT2601332	hsa-miR-4722-3p	CLIP-seq
MIRT2601333	hsa-miR-4726-5p	CLIP-seq
MIRT2601334	hsa-miR-4738-3p	CLIP-seq
MIRT2077908	hsa-miR-4752	CLIP-seq
MIRT2601335	hsa-miR-4755-5p	CLIP-seq
MIRT2601336	hsa-miR-4758-3p	CLIP-seq
MIRT2688667	hsa-miR-4778-3p	CLIP-seq
MIRT2601337	hsa-miR-4778-5p	CLIP-seq
MIRT2601338	hsa-miR-4780	CLIP-seq
MIRT2077910	hsa-miR-4782-3p	CLIP-seq
MIRT2601339	hsa-miR-4794	CLIP-seq
MIRT2601340	hsa-miR-483-3p	CLIP-seq
MIRT2077911	hsa-miR-508-3p	CLIP-seq
MIRT2601341	hsa-miR-511	CLIP-seq
MIRT2601342	hsa-miR-513a-5p	CLIP-seq
MIRT2601343	hsa-miR-516a-3p	CLIP-seq
MIRT2601344	hsa-miR-548q	CLIP-seq
MIRT2688668	hsa-miR-558	CLIP-seq
MIRT2601345	hsa-miR-614	CLIP-seq
MIRT2077913	hsa-miR-619	CLIP-seq
MIRT2601346	hsa-miR-623	CLIP-seq
MIRT2077914	hsa-miR-642b	CLIP-seq
MIRT2601347	hsa-miR-659	CLIP-seq
MIRT2601348	hsa-miR-668	CLIP-seq
MIRT2601349	hsa-miR-764	CLIP-seq
MIRT2601350	hsa-miR-765	CLIP-seq
MIRT2688669	hsa-miR-876-5p	CLIP-seq
MIRT2601351	hsa-miR-885-5p	CLIP-seq
MIRT2601352	hsa-miR-887	CLIP-seq
MIRT2688670	hsa-miR-890	CLIP-seq
MIRT2601353	hsa-miR-9	CLIP-seq
MIRT2601354	hsa-miR-939	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17299037, 20826780
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005886	Component	Plasma membrane	TAS	7929370
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007596	Process	Blood coagulation	IEA
GO:0007599	Process	Hemostasis	IEA
GO:0009986	Component	Cell surface	HDA	19581412
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038023	Function	Signaling receptor activity	TAS	7929370
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050819	Process	Negative regulation of coagulation	IBA
GO:0050819	Process	Negative regulation of coagulation	IMP	19696402
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
600646	9452	ENSG00000101000

Protein

UniProt ID

Q9UNN8

Protein name

Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201)

Protein function

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

PDB

1L8J , 1LQV , 3JTC , 4V3D , 4V3E , 6SNY , 7OKS , 7OKT , 7OKU , 7OKV , 7Q5D , 8C44

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16497	MHC_I_3	1 → 199	MHC-I family domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Sequence

MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEG
PDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCEL
PPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELRE
FLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC

Sequence length

238

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (74)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Anemia	Associate	37791774
Anemia Sickle Cell	Inhibit	34115805
Arthritis Psoriatic	Associate	17491095
Atrial Fibrillation	Associate	40304040
Blood Coagulation Disorders	Inhibit	21394629
Blood Coagulation Disorders	Associate	33683204, 36814838, 36982991
Brain Edema	Associate	34549725
Breast Neoplasms	Associate	20103682, 25407022, 29217770, 29997232
Cardiovascular Diseases	Associate	18680534
Carotid Stenosis	Associate	17170365
Cartilage Diseases	Associate	24495480
Cerebral Infarction	Associate	30383853, 40304040
Coronary Artery Disease	Associate	26908601, 35264566
Coronary Artery Disease	Inhibit	35264566
Coronary Disease	Associate	18680534
COVID 19	Inhibit	33683204, 35033854
Diabetic Nephropathies	Inhibit	26990852
Diabetic Nephropathies	Associate	26990852
Disease Susceptibility	Associate	15954900
Glioblastoma	Associate	22591734
Hemophilia A	Associate	17659055
Hypertensive Retinopathy	Associate	29025399
Hypomagnesemia 5 Renal with Ocular Involvement	Associate	15954900
Hypothermia	Inhibit	37369465
Inflammation	Inhibit	21394629, 33756504, 35264566
Inflammation	Associate	22193922, 28804104, 35264566, 37791774
Inflammatory Bowel Diseases	Associate	35018451
Intracranial Thrombosis	Associate	23741007, 37175682
Kidney Diseases	Associate	15954900
Leukemia	Associate	23342274
Livedoid Vasculopathy	Associate	15954900
Lupus Erythematosus Systemic	Associate	15954900
Lupus Nephritis	Associate	15954900, 19286697
Malaria	Associate	25541704, 28732053, 29025399, 33203751, 37791774
Malaria Cerebral	Associate	23741007, 25541704, 27406562, 29025399, 29339517, 30610112, 33203751, 34549725
Memory Disorders	Associate	18680534
Meningococcal Infections	Associate	11496851
Microvascular Angina	Associate	25541704, 34966385
Mucocutaneous Lymph Node Syndrome	Associate	31645483
Multiple Organ Failure	Associate	25608138
Myocardial Infarction	Associate	18757851
Myotonic Dystrophy	Associate	34462518
Nasopharyngeal Carcinoma	Associate	35169126
Neoplasm Metastasis	Associate	35169126
Neoplasms	Associate	18758062, 22591734, 25407022, 29217770, 35169126, 36814838, 36920782, 38237862
Obesity	Associate	22193922
Obesity Maternal	Associate	20141580
Osteoarthritis	Associate	17491095
Ovarian Neoplasms	Associate	26082331
Peritonitis	Associate	31734630
Pneumonia Pneumococcal	Associate	30290852
Prader Willi Syndrome	Associate	22193922
Pre Eclampsia	Associate	32003123
Preeclamptic toxemia	Inhibit	32003123
Protein C Deficiency	Associate	19133979, 23389250
Pyruvate Carboxylase Deficiency Disease	Associate	17491095
Respiratory Distress Syndrome	Associate	27215212, 28732053
Retinitis Pigmentosa	Associate	29025399
Sepsis	Associate	15710622, 16444434, 21394629
Severe Acute Respiratory Syndrome	Associate	29025399
Shock Septic	Associate	30290852
Skin Neoplasms	Associate	35018451
Stroke	Associate	18680534, 30383853
Synovial Cyst	Associate	24495480
Systemic Inflammatory Response Syndrome	Associate	28804104
Thrombosis	Associate	14576048, 18403391, 19133979, 22193922, 23389250, 25760048, 34981912, 35264566
Triple Negative Breast Neoplasms	Associate	29217770, 34281556
Usher Syndrome Type IE	Associate	23741007
Uterine Cervical Neoplasms	Associate	37308506
Vascular Diseases	Associate	35264566
Vascular System Injuries	Associate	17170365
Venous Thromboembolism	Associate	18403391, 18757851, 19222470, 20141580, 24051141, 26908601, 35264566, 37308506
Venous Thromboembolism	Stimulate	35264566
Venous Thrombosis	Associate	15304035, 18403391, 20141580, 21980494, 22443383

PROCR (protein C receptor)