HYOU1 (hypoxia up-regulated 1)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10525 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Hypoxia up-regulated 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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HYOU1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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GRP-170, Grp170, HSP12A, IMD59, ORP-150, ORP150 |
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Chromosome
Chromosome number
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11 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q23.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5` UTR is involved in stress-dependent induction, resulting in the accumulation of this p |
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miRNA
miRNA information provided by mirtarbase database.
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| Transcription factors | ||||||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q9Y4L1 | ||||||||||
| Protein name | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | ||||||||||
| Protein function | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticu | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrop | ||||||||||
| Sequence |
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| Sequence length | 999 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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