Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10525
Gene name Gene Name - the full gene name approved by the HGNC.
Hypoxia up-regulated 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HYOU1
Synonyms (NCBI Gene) Gene synonyms aliases
GRP-170, Grp170, HSP12A, IMD59, ORP-150, ORP150
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IMD59
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5` UTR is involved in stress-dependent induction, resulting in the accumulation of this p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016306 hsa-miR-193b-3p Microarray 20304954
MIRT016902 hsa-miR-335-5p Microarray 18185580
MIRT047102 hsa-miR-183-5p CLASH 23622248
MIRT041955 hsa-miR-484 CLASH 23622248
MIRT041955 hsa-miR-484 CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
FOXO1 Unknown 21296878
SIRT1 Activation 22564731
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000774 Function Adenyl-nucleotide exchange factor activity ISS
GO:0002931 Process Response to ischemia ISS
GO:0005515 Function Protein binding IPI 26496610, 30021884
GO:0005524 Function ATP binding IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601746 16931 ENSG00000149428
Protein
UniProt ID Q9Y4L1
Protein name Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Protein function Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 35 678 Hsp70 protein Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrop
Sequence
MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL
NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF
PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF
NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC
TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR
ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP
GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV
YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK
VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK
AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT
VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK
SEAQKPSEKAEAGPEGVA
PAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV
QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST
WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR
LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR
EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV
ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL
Sequence length 999
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein processing in endoplasmic reticulum   Scavenging by Class F Receptors
XBP1(S) activates chaperone genes
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Granulocytopenia with immunoglobulin abnormality Granulocytopenia with Immunoglobulin Abnormality rs1944619636, rs1944464234 27913302
Spinocerebellar ataxia SPINOCEREBELLAR ATAXIA 17 rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926
View all (203 more)
24413982
Unknown
Disease term Disease name Evidence References Source
Granulocytopenia With Immunoglobulin Abnormality granulocytopenia with immunoglobulin abnormality GenCC
Associations from Text Mining
Disease Name Relationship Type References
Atherosclerosis Associate 19106412
Breast Neoplasms Associate 31173282
Breast Neoplasms Stimulate 39201646
Carcinoma Ovarian Epithelial Associate 31173282
Congenital Abnormalities Associate 35822684
Diabetes Complications Associate 35806251
Diabetic Nephropathies Associate 18776125
Hypoxia Stimulate 39201646
Hypoxia Ischemia Brain Associate 20626887
Infarction Associate 20626887