Gene Gene information from NCBI Gene database.
Entrez ID 10525
Gene name Hypoxia up-regulated 1
Gene symbol HYOU1
Synonyms (NCBI Gene)
GRP-170Grp170HSP12AIMD59ORP-150ORP150
Chromosome 11
Chromosome location 11q23.3
Summary The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5` UTR is involved in stress-dependent induction, resulting in the accumulation of this p
miRNA miRNA information provided by mirtarbase database.
793
miRTarBase ID miRNA Experiments Reference
MIRT016306 hsa-miR-193b-3p Microarray 20304954
MIRT016902 hsa-miR-335-5p Microarray 18185580
MIRT047102 hsa-miR-183-5p CLASH 23622248
MIRT041955 hsa-miR-484 CLASH 23622248
MIRT041955 hsa-miR-484 CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
FOXO1 Unknown 21296878
SIRT1 Activation 22564731
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000774 Function Adenyl-nucleotide exchange factor activity IBA
GO:0002931 Process Response to ischemia IEA
GO:0002931 Process Response to ischemia ISS
GO:0005515 Function Protein binding IPI 26496610, 30021884, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601746 16931 ENSG00000149428
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y4L1
Protein name Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Protein function Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 35 678 Hsp70 protein Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrop
Sequence
MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL
NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARF
PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFF
NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVC
TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVR
ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVP
GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV
YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRK
VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIK
AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT
VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDK
SEAQKPSEKAEAGPEGVA
PAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSV
QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAAST
WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGAR
LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDR
EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKV
ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL
Sequence length 999
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum   Scavenging by Class F Receptors
XBP1(S) activates chaperone genes
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
79
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Granulocytopenia with immunoglobulin abnormality Pathogenic rs1944619636, rs1944464234 RCV000735793
RCV000735794
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign; Likely benign rs115207968, rs11822958, rs34446044 RCV005914414
RCV005912984
RCV005913283
Cervical cancer Benign; Uncertain significance rs149598298, rs77350634, rs201754853 RCV005914366
RCV005913014
RCV005910949
Cholangiocarcinoma Benign rs11822958 RCV005912991
Clear cell carcinoma of kidney Likely benign; Benign; Uncertain significance rs201408509, rs34446044, rs201754853 RCV005932107
RCV005913284
RCV005910950
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Atherosclerosis Associate 19106412
Breast Neoplasms Associate 31173282
Breast Neoplasms Stimulate 39201646
Carcinoma Ovarian Epithelial Associate 31173282
Congenital Abnormalities Associate 35822684
Diabetes Complications Associate 35806251
Diabetic Nephropathies Associate 18776125
Hypoxia Stimulate 39201646
Hypoxia Ischemia Brain Associate 20626887
Infarction Associate 20626887