Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10499
Gene name Gene Name - the full gene name approved by the HGNC.	Nuclear receptor coactivator 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NCOA2
Synonyms (NCBI Gene) Gene synonyms aliases	GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004004	hsa-miR-137	Luciferase reporter assay, qRT-PCR, Western blot	18381414
MIRT041215	hsa-miR-193b-3p	CLASH	23622248
MIRT501843	hsa-miR-200c-3p	PAR-CLIP	24398324
MIRT501842	hsa-miR-200b-3p	PAR-CLIP	24398324
MIRT501841	hsa-miR-429	PAR-CLIP	24398324
MIRT501840	hsa-miR-3120-3p	PAR-CLIP	24398324
MIRT501839	hsa-miR-6750-5p	PAR-CLIP	24398324
MIRT501838	hsa-miR-6822-5p	PAR-CLIP	24398324
MIRT501837	hsa-miR-7515	PAR-CLIP	24398324
MIRT501836	hsa-miR-3179	PAR-CLIP	24398324
MIRT501835	hsa-miR-539-5p	PAR-CLIP	24398324
MIRT501833	hsa-miR-4471	PAR-CLIP	24398324
MIRT501834	hsa-miR-8059	PAR-CLIP	24398324
MIRT501832	hsa-miR-6864-5p	PAR-CLIP	24398324
MIRT440136	hsa-miR-1185-5p	HITS-CLIP	24374217
MIRT440135	hsa-miR-544a	HITS-CLIP	24374217
MIRT440136	hsa-miR-1185-5p	HITS-CLIP	24374217
MIRT440135	hsa-miR-544a	HITS-CLIP	24374217
MIRT501842	hsa-miR-200b-3p	PAR-CLIP	27292025
MIRT501843	hsa-miR-200c-3p	PAR-CLIP	27292025
MIRT501840	hsa-miR-3120-3p	PAR-CLIP	27292025
MIRT501836	hsa-miR-3179	PAR-CLIP	27292025
MIRT501841	hsa-miR-429	PAR-CLIP	27292025
MIRT501833	hsa-miR-4471	PAR-CLIP	27292025
MIRT501835	hsa-miR-539-5p	PAR-CLIP	27292025
MIRT501839	hsa-miR-6750-5p	PAR-CLIP	27292025
MIRT501838	hsa-miR-6822-5p	PAR-CLIP	27292025
MIRT501832	hsa-miR-6864-5p	PAR-CLIP	27292025
MIRT501837	hsa-miR-7515	PAR-CLIP	27292025
MIRT501834	hsa-miR-8059	PAR-CLIP	27292025
MIRT501843	hsa-miR-200c-3p	PAR-CLIP	24398324
MIRT501842	hsa-miR-200b-3p	PAR-CLIP	24398324
MIRT501841	hsa-miR-429	PAR-CLIP	24398324
MIRT501840	hsa-miR-3120-3p	PAR-CLIP	24398324
MIRT501839	hsa-miR-6750-5p	PAR-CLIP	24398324
MIRT501838	hsa-miR-6822-5p	PAR-CLIP	24398324
MIRT501837	hsa-miR-7515	PAR-CLIP	24398324
MIRT501836	hsa-miR-3179	PAR-CLIP	24398324
MIRT501835	hsa-miR-539-5p	PAR-CLIP	24398324
MIRT501833	hsa-miR-4471	PAR-CLIP	24398324
MIRT501834	hsa-miR-8059	PAR-CLIP	24398324
MIRT501832	hsa-miR-6864-5p	PAR-CLIP	24398324
MIRT1176726	hsa-miR-125a-3p	CLIP-seq
MIRT1176727	hsa-miR-1292	CLIP-seq
MIRT1176728	hsa-miR-181a	CLIP-seq
MIRT1176729	hsa-miR-181b	CLIP-seq
MIRT1176730	hsa-miR-181c	CLIP-seq
MIRT1176731	hsa-miR-181d	CLIP-seq
MIRT1176732	hsa-miR-1976	CLIP-seq
MIRT1176733	hsa-miR-223	CLIP-seq
MIRT1176734	hsa-miR-3064-3p	CLIP-seq
MIRT1176735	hsa-miR-3120-5p	CLIP-seq
MIRT1176736	hsa-miR-3121-3p	CLIP-seq
MIRT1176737	hsa-miR-3152-5p	CLIP-seq
MIRT1176738	hsa-miR-3185	CLIP-seq
MIRT1176739	hsa-miR-346	CLIP-seq
MIRT1176740	hsa-miR-3620	CLIP-seq
MIRT1176741	hsa-miR-362-5p	CLIP-seq
MIRT1176742	hsa-miR-3646	CLIP-seq
MIRT1176743	hsa-miR-3647-3p	CLIP-seq
MIRT1176744	hsa-miR-3660	CLIP-seq
MIRT1176745	hsa-miR-3685	CLIP-seq
MIRT1176746	hsa-miR-3918	CLIP-seq
MIRT1176747	hsa-miR-3934	CLIP-seq
MIRT1176748	hsa-miR-3940-5p	CLIP-seq
MIRT1176749	hsa-miR-4259	CLIP-seq
MIRT1176750	hsa-miR-4262	CLIP-seq
MIRT1176751	hsa-miR-4266	CLIP-seq
MIRT1176752	hsa-miR-4288	CLIP-seq
MIRT1176753	hsa-miR-4292	CLIP-seq
MIRT1176754	hsa-miR-433	CLIP-seq
MIRT1176755	hsa-miR-4421	CLIP-seq
MIRT1176756	hsa-miR-4475	CLIP-seq
MIRT1176757	hsa-miR-448	CLIP-seq
MIRT1176758	hsa-miR-4507	CLIP-seq
MIRT1176759	hsa-miR-4526	CLIP-seq
MIRT1176760	hsa-miR-4640-5p	CLIP-seq
MIRT1176761	hsa-miR-4646-5p	CLIP-seq
MIRT1176762	hsa-miR-4650-5p	CLIP-seq
MIRT1176763	hsa-miR-4659a-3p	CLIP-seq
MIRT1176764	hsa-miR-4659b-3p	CLIP-seq
MIRT1176765	hsa-miR-4685-5p	CLIP-seq
MIRT1176766	hsa-miR-4699-3p	CLIP-seq
MIRT1176767	hsa-miR-4708-5p	CLIP-seq
MIRT1176768	hsa-miR-4722-3p	CLIP-seq
MIRT1176769	hsa-miR-4726-5p	CLIP-seq
MIRT1176770	hsa-miR-4728-3p	CLIP-seq
MIRT1176771	hsa-miR-4755-3p	CLIP-seq
MIRT1176772	hsa-miR-4760-3p	CLIP-seq
MIRT1176773	hsa-miR-4774-3p	CLIP-seq
MIRT1176774	hsa-miR-4775	CLIP-seq
MIRT1176775	hsa-miR-487a	CLIP-seq
MIRT1176776	hsa-miR-494	CLIP-seq
MIRT1176777	hsa-miR-498	CLIP-seq
MIRT1176778	hsa-miR-500b	CLIP-seq
MIRT1176779	hsa-miR-501-5p	CLIP-seq
MIRT1176780	hsa-miR-505	CLIP-seq
MIRT1176781	hsa-miR-513c	CLIP-seq
MIRT1176782	hsa-miR-514b-5p	CLIP-seq
MIRT1176783	hsa-miR-520d-5p	CLIP-seq
MIRT1176784	hsa-miR-524-5p	CLIP-seq
MIRT1176785	hsa-miR-626	CLIP-seq
MIRT1176786	hsa-miR-632	CLIP-seq
MIRT1176787	hsa-miR-651	CLIP-seq
MIRT1176788	hsa-miR-659	CLIP-seq
MIRT1176789	hsa-miR-764	CLIP-seq
MIRT1176790	hsa-miR-767-3p	CLIP-seq
MIRT1176791	hsa-miR-942	CLIP-seq
MIRT1176792	hsa-miR-944	CLIP-seq
MIRT2051186	hsa-miR-1323	CLIP-seq
MIRT2051187	hsa-miR-2110	CLIP-seq
MIRT2051188	hsa-miR-2115	CLIP-seq
MIRT2051189	hsa-miR-3686	CLIP-seq
MIRT2051190	hsa-miR-4271	CLIP-seq
MIRT2051191	hsa-miR-4457	CLIP-seq
MIRT2051192	hsa-miR-4494	CLIP-seq
MIRT2051193	hsa-miR-4667-5p	CLIP-seq
MIRT2051194	hsa-miR-4700-5p	CLIP-seq
MIRT2051195	hsa-miR-4725-3p	CLIP-seq
MIRT2051196	hsa-miR-513b	CLIP-seq
MIRT2051197	hsa-miR-516a-3p	CLIP-seq
MIRT2051198	hsa-miR-548o	CLIP-seq
MIRT2051199	hsa-miR-577	CLIP-seq
MIRT2051200	hsa-miR-582-3p	CLIP-seq
MIRT2051201	hsa-miR-624	CLIP-seq
MIRT1176732	hsa-miR-1976	CLIP-seq
MIRT2280327	hsa-miR-2052	CLIP-seq
MIRT2051188	hsa-miR-2115	CLIP-seq
MIRT1176734	hsa-miR-3064-3p	CLIP-seq
MIRT1176736	hsa-miR-3121-3p	CLIP-seq
MIRT2280328	hsa-miR-3124-3p	CLIP-seq
MIRT2280329	hsa-miR-3144-3p	CLIP-seq
MIRT2280330	hsa-miR-3155	CLIP-seq
MIRT2280331	hsa-miR-3155b	CLIP-seq
MIRT2280332	hsa-miR-330-3p	CLIP-seq
MIRT2280333	hsa-miR-338-5p	CLIP-seq
MIRT2280334	hsa-miR-342-3p	CLIP-seq
MIRT1176745	hsa-miR-3685	CLIP-seq
MIRT2280335	hsa-miR-3692	CLIP-seq
MIRT2280336	hsa-miR-3924	CLIP-seq
MIRT2280337	hsa-miR-3925-3p	CLIP-seq
MIRT2280338	hsa-miR-409-3p	CLIP-seq
MIRT2280339	hsa-miR-4438	CLIP-seq
MIRT2280340	hsa-miR-4448	CLIP-seq
MIRT2280341	hsa-miR-4463	CLIP-seq
MIRT1176757	hsa-miR-448	CLIP-seq
MIRT2051192	hsa-miR-4494	CLIP-seq
MIRT2280342	hsa-miR-4639-5p	CLIP-seq
MIRT2280343	hsa-miR-4687-5p	CLIP-seq
MIRT2280344	hsa-miR-4699-5p	CLIP-seq
MIRT1176768	hsa-miR-4722-3p	CLIP-seq
MIRT2280345	hsa-miR-4777-3p	CLIP-seq
MIRT2280346	hsa-miR-484	CLIP-seq
MIRT1176775	hsa-miR-487a	CLIP-seq
MIRT2280347	hsa-miR-513a-5p	CLIP-seq
MIRT2051197	hsa-miR-516a-3p	CLIP-seq
MIRT2280348	hsa-miR-548c-3p	CLIP-seq
MIRT2051200	hsa-miR-582-3p	CLIP-seq
MIRT2280349	hsa-miR-627	CLIP-seq
MIRT1176788	hsa-miR-659	CLIP-seq
MIRT2280350	hsa-miR-766	CLIP-seq
MIRT2280351	hsa-miR-875-5p	CLIP-seq
MIRT2578802	hsa-miR-1207-5p	CLIP-seq
MIRT2578803	hsa-miR-1251	CLIP-seq
MIRT1176727	hsa-miR-1292	CLIP-seq
MIRT1176728	hsa-miR-181a	CLIP-seq
MIRT1176729	hsa-miR-181b	CLIP-seq
MIRT1176730	hsa-miR-181c	CLIP-seq
MIRT1176731	hsa-miR-181d	CLIP-seq
MIRT1176734	hsa-miR-3064-3p	CLIP-seq
MIRT1176735	hsa-miR-3120-5p	CLIP-seq
MIRT1176737	hsa-miR-3152-5p	CLIP-seq
MIRT1176738	hsa-miR-3185	CLIP-seq
MIRT2578804	hsa-miR-335	CLIP-seq
MIRT1176739	hsa-miR-346	CLIP-seq
MIRT1176740	hsa-miR-3620	CLIP-seq
MIRT1176744	hsa-miR-3660	CLIP-seq
MIRT1176746	hsa-miR-3918	CLIP-seq
MIRT1176750	hsa-miR-4262	CLIP-seq
MIRT2578805	hsa-miR-4279	CLIP-seq
MIRT1176752	hsa-miR-4288	CLIP-seq
MIRT1176753	hsa-miR-4292	CLIP-seq
MIRT1176755	hsa-miR-4421	CLIP-seq
MIRT2578806	hsa-miR-450b-5p	CLIP-seq
MIRT1176759	hsa-miR-4526	CLIP-seq
MIRT1176760	hsa-miR-4640-5p	CLIP-seq
MIRT1176761	hsa-miR-4646-5p	CLIP-seq
MIRT1176762	hsa-miR-4650-5p	CLIP-seq
MIRT1176765	hsa-miR-4685-5p	CLIP-seq
MIRT1176766	hsa-miR-4699-3p	CLIP-seq
MIRT1176767	hsa-miR-4708-5p	CLIP-seq
MIRT1176769	hsa-miR-4726-5p	CLIP-seq
MIRT1176770	hsa-miR-4728-3p	CLIP-seq
MIRT2578807	hsa-miR-4736	CLIP-seq
MIRT1176771	hsa-miR-4755-3p	CLIP-seq
MIRT2578808	hsa-miR-4763-3p	CLIP-seq
MIRT1176773	hsa-miR-4774-3p	CLIP-seq
MIRT1176777	hsa-miR-498	CLIP-seq
MIRT1176780	hsa-miR-505	CLIP-seq
MIRT2578809	hsa-miR-507	CLIP-seq
MIRT2578810	hsa-miR-557	CLIP-seq
MIRT1176785	hsa-miR-626	CLIP-seq
MIRT1176786	hsa-miR-632	CLIP-seq
MIRT1176790	hsa-miR-767-3p	CLIP-seq
MIRT2578811	hsa-miR-873	CLIP-seq
MIRT2578803	hsa-miR-1251	CLIP-seq
MIRT2685921	hsa-miR-1286	CLIP-seq
MIRT1176727	hsa-miR-1292	CLIP-seq
MIRT1176734	hsa-miR-3064-3p	CLIP-seq
MIRT1176735	hsa-miR-3120-5p	CLIP-seq
MIRT1176737	hsa-miR-3152-5p	CLIP-seq
MIRT1176738	hsa-miR-3185	CLIP-seq
MIRT1176739	hsa-miR-346	CLIP-seq
MIRT1176740	hsa-miR-3620	CLIP-seq
MIRT1176746	hsa-miR-3918	CLIP-seq
MIRT1176752	hsa-miR-4288	CLIP-seq
MIRT1176753	hsa-miR-4292	CLIP-seq
MIRT1176755	hsa-miR-4421	CLIP-seq
MIRT1176756	hsa-miR-4475	CLIP-seq
MIRT2685922	hsa-miR-4477b	CLIP-seq
MIRT2578806	hsa-miR-450b-5p	CLIP-seq
MIRT1176760	hsa-miR-4640-5p	CLIP-seq
MIRT1176761	hsa-miR-4646-5p	CLIP-seq
MIRT1176762	hsa-miR-4650-5p	CLIP-seq
MIRT1176765	hsa-miR-4685-5p	CLIP-seq
MIRT1176766	hsa-miR-4699-3p	CLIP-seq
MIRT1176767	hsa-miR-4708-5p	CLIP-seq
MIRT2685923	hsa-miR-4722-5p	CLIP-seq
MIRT1176769	hsa-miR-4726-5p	CLIP-seq
MIRT1176770	hsa-miR-4728-3p	CLIP-seq
MIRT1176771	hsa-miR-4755-3p	CLIP-seq
MIRT1176773	hsa-miR-4774-3p	CLIP-seq
MIRT1176774	hsa-miR-4775	CLIP-seq
MIRT2685924	hsa-miR-495	CLIP-seq
MIRT1176777	hsa-miR-498	CLIP-seq
MIRT1176780	hsa-miR-505	CLIP-seq
MIRT2578809	hsa-miR-507	CLIP-seq
MIRT2578810	hsa-miR-557	CLIP-seq
MIRT1176785	hsa-miR-626	CLIP-seq
MIRT1176786	hsa-miR-632	CLIP-seq
MIRT1176788	hsa-miR-659	CLIP-seq
MIRT1176790	hsa-miR-767-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
CTNNB1	Unknown	16141201

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0001162	Function	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	17363140, 22504882, 26553876
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0003713	Function	Transcription coactivator activity	ISS
GO:0003713	Function	Transcription coactivator activity	NAS	9430642
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	11265755, 15563469, 17947383, 21478865, 22504882, 24561505, 28514442, 33640491, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	26733313
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005667	Component	Transcription regulator complex	IPI	9430642, 11265755, 21152046, 26820900
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	8670870
GO:0007623	Process	Circadian rhythm	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010906	Process	Regulation of glucose metabolic process	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016922	Function	Nuclear receptor binding	IBA
GO:0016922	Function	Nuclear receptor binding	IEA
GO:0016922	Function	Nuclear receptor binding	IPI	10478845, 18798693
GO:0017162	Function	Aryl hydrocarbon receptor binding	IPI	15641800
GO:0019216	Process	Regulation of lipid metabolic process	IEA
GO:0019216	Process	Regulation of lipid metabolic process	ISS
GO:0019904	Function	Protein domain specific binding	IPI	11583620
GO:0032570	Process	Response to progesterone	IEA
GO:0032870	Process	Cellular response to hormone stimulus	IBA
GO:0032922	Process	Circadian regulation of gene expression	IEA
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0032991	Component	Protein-containing complex	IMP	15641800
GO:0035357	Process	Peroxisome proliferator activated receptor signaling pathway	NAS	16373399
GO:0042789	Process	MRNA transcription by RNA polymerase II	ISS
GO:0042789	Process	MRNA transcription by RNA polymerase II	NAS	9430642
GO:0045475	Process	Locomotor rhythm	IEA
GO:0045879	Process	Negative regulation of smoothened signaling pathway	IMP	39531503
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9430642, 11265755
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	EXP	15258145
GO:0090575	Component	RNA polymerase II transcription regulator complex	NAS	9430642
GO:0140416	Function	Transcription regulator inhibitor activity	IDA	39531503
GO:1900076	Process	Regulation of cellular response to insulin stimulus	NAS	16373399
GO:1904017	Process	Cellular response to Thyroglobulin triiodothyronine	IEA
GO:1904179	Process	Positive regulation of adipose tissue development	NAS	16373399

MIM	HGNC	e!Ensembl
601993	7669	ENSG00000140396

Protein

UniProt ID

Q15596

Protein name

Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)

Protein function

Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal do

PDB

1GWQ , 1GWR , 1M2Z , 1MV9 , 1MVC , 1MZN , 1P93 , 1T63 , 1T65 , 1UHL , 1YOK , 1ZDT , 1ZDU , 1ZKY , 2AO6 , 2B1V , 2B1Z , 2B23 , 2FAI , 2G44 , 2G5O , 2LDC , 2P15 , 2P1T , 2P1U , 2P1V , 2Q7J , 2Q7L , 2YJD , 2ZXZ , 2ZY0 , 3A9E , 3CLD , 3DZU , 3DZY , 3E00 , 3E7C , 3E94 , 3ERD , 3FUG , 3GN8 , 3K22 , 3K23 , 3KWY , 3KYT , 3L0E , 3L0J , 3L0L , 3O1D , 3O1E , 3OAP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00989	PAS	115 → 215	PAS fold	Domain
PF14598	PAS_11	267 → 379		Domain
PF16665	NCOA_u2	463 → 587		Disordered
PF08832	SRC-1	636 → 709	Steroid receptor coactivator	Domain
PF16279	DUF4927	731 → 816	Domain of unknown function (DUF4927)	Family
PF08815	Nuc_rec_co-act	1071 → 1117	Nuclear receptor coactivator	Domain
PF07469	DUF1518	1281 → 1338	Domain of unknown function (DUF1518)	Domain

Sequence

MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
SNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPG
QPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQAL
SEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA
ESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASS
LSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESS
STAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK
LIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAII
NDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG
PFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSA
VRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGG
PQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALL
DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQ
AQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQ
QNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQ
RTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATT
PQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQAN
TSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGG
NLFPNQLPGMDMIKQEGDTTRKYC

Sequence length

1464

Interactions

View interactions

	KEGG		Reactome
	Estrogen signaling pathway Thyroid hormone signaling pathway		RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Estrogen-dependent gene expression

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Show/Hide Text Mining Associations (48)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	33593309
Angiofibroma	Associate	22337624, 27633981, 30179902, 37680034
Breast Neoplasms	Associate	19095746, 20920219, 21059860, 23936147, 24282087, 24304549, 27107013
Cap Myopathy	Associate	27606620
Carcinogenesis	Associate	34837064
Carcinoma	Associate	23463663, 26501226, 29218853, 30179902, 34067464, 35452896, 38607246
Carcinoma Pancreatic Ductal	Associate	36302831
Carcinoma Squamous Cell	Associate	34398873
Chondrosarcoma Mesenchymal	Associate	22034177, 23185413, 24839999, 30819134, 34837064, 35342947, 35672279, 37225644, 40301759
Colorectal Neoplasms	Inhibit	18360708
Dyslipidemias	Associate	26261634
Embolism Fat	Associate	26261634
Endometrial Neoplasms	Associate	22876322, 30177747
Ependymoma	Associate	33576087, 34389065
Head and Neck Neoplasms	Associate	35672279
Hemangioma	Associate	40416971
Histiocytosis Langerhans Cell	Associate	29070620
Hypoxia	Stimulate	27560795
Hypoxia Brain	Associate	27560795
Isodicentric Chromosome 15 Syndrome	Associate	17697320, 9558366, 9731070
Kidney Neoplasms	Associate	30179902
Leukemia	Associate	22337624
Leukemia Biphenotypic Acute	Associate	17697320, 9731070
Leukemia Myeloid Acute	Associate	9558366, 9731070
Malignant Teratocarcinosarcoma	Associate	30829729
Mesothelioma Malignant	Associate	22011668
Mouth Diseases	Associate	24839999
Neoplasm Metastasis	Associate	23559371, 34837064
Neoplasms	Associate	21088497, 24282087, 24839999, 26267537, 27633981, 29218853, 31008539, 33576087
Neoplasms	Inhibit	23936147, 26461474, 34398873
Neoplasms	Stimulate	30177747
Non alcoholic Fatty Liver Disease	Associate	37861538
Obesity	Associate	26261634
Ovarian Neoplasms	Associate	30273195, 31464709, 37221583, 37406360
Pelvic Inflammatory Disease	Associate	24220311
Polycystic Ovary Syndrome	Stimulate	30177747
Prostatic Neoplasms	Associate	19240160, 21088497, 27225190
Prostatic Neoplasms	Stimulate	27606620
Pulmonary Arterial Hypertension	Associate	20081107
Rhabdomyosarcoma	Associate	19953635, 23463663, 30720533, 33574497, 38607246
Rhabdomyosarcoma 1	Associate	34067464
Sarcoma	Associate	22337624, 29104083, 29218853, 30179902, 33574497
Sarcoma Small Cell	Associate	30179902
Supratentorial Neoplasms	Associate	34389065
Tarlov Cysts	Associate	24768607
Urethral Neoplasms	Associate	18845648
Uterine Diseases	Stimulate	30177747
Uterine Neoplasms	Associate	30273195, 31464709

NCOA2 (nuclear receptor coactivator 2)