Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10493
Gene name Gene Name - the full gene name approved by the HGNC.
Vesicle amine transport 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VAT1
Synonyms (NCBI Gene) Gene synonyms aliases
VATI
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.31
Summary Summary of gene provided in NCBI Entrez Gene.
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved i
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016832 hsa-miR-335-5p Microarray 18185580
MIRT048825 hsa-miR-93-5p CLASH 23622248
MIRT640991 hsa-miR-6892-3p HITS-CLIP 23824327
MIRT640990 hsa-miR-2276-5p HITS-CLIP 23824327
MIRT640989 hsa-miR-4469 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region TAS
GO:0005741 Component Mitochondrial outer membrane IEA
GO:0008270 Function Zinc ion binding IEA
GO:0010637 Process Negative regulation of mitochondrial fusion IMP 17105775
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604631 16919 ENSG00000108828
Protein
UniProt ID Q99536
Protein name Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-)
Protein function Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin pro
PDB 6K9Y , 6LHR , 6LII
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08240 ADH_N 76 144 Alcohol dehydrogenase GroES-like domain Domain
PF13602 ADH_zinc_N_2 232 385 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain. Also expressed in glioblastoma cells. {ECO:0000269|PubMed:19508442}.
Sequence
MSDEREVAEAATGEDASSPPPKTEAASDPQHPAASEGAAAAAASPPLLRCLVLTGFGGYD
KVKLQSRPAAPPAPGPGQLTLRLRACGLNFADLMARQGLYDRLPPLPVTPGMEGAGVVIA
VGEGVSDRKAGDRVMVLNRSGMWQ
EEVTVPSVQTFLIPEAMTFEEAAALLVNYITAYMVL
FDFGNLQPGHSVLVHMAAGGVGMAAVQLCRTVENVTVFGTASASKHEALKENGVTHPIDY
HTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYNLLKPMGKVVTYGMANLLTGPKRNLMA
LARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSGVVARLLALYNQGHIKPHIDS
VWPFEKVADAMKQMQEKKNVGKVLL
VPGPEKEN
Sequence length 393
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778
Associations from Text Mining
Disease Name Relationship Type References
Epilepsy Generalized Associate 40495522
Glioma Associate 33576871
Huntington Disease Associate 39284371
Inflammation Associate 33576871
Mitochondrial Diseases Associate 39284371
Stomach Neoplasms Associate 34129933