Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	1048
Gene name	CEA cell adhesion molecule 5
Gene symbol	CEACAM5
Synonyms (NCBI Gene)	CD66eCEA
Chromosome	19
Chromosome location	19q13.2
Summary	This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018234	hsa-miR-335-5p	Microarray	18185580
MIRT677795	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT677794	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT677793	hsa-miR-764	HITS-CLIP	23824327
MIRT677792	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677791	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677790	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677789	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677788	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677787	hsa-miR-1976	HITS-CLIP	23824327
MIRT677786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677785	hsa-miR-4783-5p	HITS-CLIP	23824327
MIRT677784	hsa-miR-3199	HITS-CLIP	23824327
MIRT677783	hsa-miR-8052	HITS-CLIP	23824327
MIRT677782	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677781	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677780	hsa-miR-4279	HITS-CLIP	23824327
MIRT677795	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT677794	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT677793	hsa-miR-764	HITS-CLIP	23824327
MIRT677792	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677791	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677790	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677789	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677788	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677787	hsa-miR-1976	HITS-CLIP	23824327
MIRT677786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677785	hsa-miR-4783-5p	HITS-CLIP	23824327
MIRT677784	hsa-miR-3199	HITS-CLIP	23824327
MIRT677783	hsa-miR-8052	HITS-CLIP	23824327
MIRT677782	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT677781	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT677780	hsa-miR-4279	HITS-CLIP	23824327
MIRT882994	hsa-miR-1193	CLIP-seq
MIRT882995	hsa-miR-1208	CLIP-seq
MIRT882996	hsa-miR-122	CLIP-seq
MIRT882997	hsa-miR-1264	CLIP-seq
MIRT882998	hsa-miR-129-5p	CLIP-seq
MIRT882999	hsa-miR-134	CLIP-seq
MIRT883000	hsa-miR-150	CLIP-seq
MIRT883001	hsa-miR-1915	CLIP-seq
MIRT883002	hsa-miR-223	CLIP-seq
MIRT883003	hsa-miR-2392	CLIP-seq
MIRT883004	hsa-miR-3118	CLIP-seq
MIRT883005	hsa-miR-3135b	CLIP-seq
MIRT883006	hsa-miR-3136-5p	CLIP-seq
MIRT883007	hsa-miR-3152-3p	CLIP-seq
MIRT883008	hsa-miR-3652	CLIP-seq
MIRT883009	hsa-miR-376c	CLIP-seq
MIRT883010	hsa-miR-3944-5p	CLIP-seq
MIRT883011	hsa-miR-3973	CLIP-seq
MIRT883012	hsa-miR-410	CLIP-seq
MIRT883013	hsa-miR-4294	CLIP-seq
MIRT883014	hsa-miR-4304	CLIP-seq
MIRT883015	hsa-miR-4420	CLIP-seq
MIRT883016	hsa-miR-4430	CLIP-seq
MIRT883017	hsa-miR-4438	CLIP-seq
MIRT883018	hsa-miR-4439	CLIP-seq
MIRT883019	hsa-miR-4454	CLIP-seq
MIRT883020	hsa-miR-4513	CLIP-seq
MIRT883021	hsa-miR-4527	CLIP-seq
MIRT883022	hsa-miR-4662a-5p	CLIP-seq
MIRT883023	hsa-miR-4676-5p	CLIP-seq
MIRT883024	hsa-miR-4697-3p	CLIP-seq
MIRT883025	hsa-miR-4707-3p	CLIP-seq
MIRT883026	hsa-miR-4713-5p	CLIP-seq
MIRT883027	hsa-miR-4726-3p	CLIP-seq
MIRT883028	hsa-miR-4782-5p	CLIP-seq
MIRT883029	hsa-miR-5095	CLIP-seq
MIRT883030	hsa-miR-520g	CLIP-seq
MIRT883031	hsa-miR-520h	CLIP-seq
MIRT883032	hsa-miR-532-3p	CLIP-seq
MIRT883033	hsa-miR-548p	CLIP-seq
MIRT883034	hsa-miR-554	CLIP-seq
MIRT883035	hsa-miR-575	CLIP-seq
MIRT883036	hsa-miR-622	CLIP-seq
MIRT883037	hsa-miR-892a	CLIP-seq
MIRT1961787	hsa-miR-106a	CLIP-seq
MIRT1961788	hsa-miR-106b	CLIP-seq
MIRT1961789	hsa-miR-1206	CLIP-seq
MIRT882996	hsa-miR-122	CLIP-seq
MIRT1961790	hsa-miR-1287	CLIP-seq
MIRT1961791	hsa-miR-1324	CLIP-seq
MIRT1961792	hsa-miR-148a	CLIP-seq
MIRT1961793	hsa-miR-148b	CLIP-seq
MIRT883000	hsa-miR-150	CLIP-seq
MIRT1961794	hsa-miR-152	CLIP-seq
MIRT1961795	hsa-miR-17	CLIP-seq
MIRT883001	hsa-miR-1915	CLIP-seq
MIRT1961796	hsa-miR-20a	CLIP-seq
MIRT1961797	hsa-miR-20b	CLIP-seq
MIRT1961798	hsa-miR-302a	CLIP-seq
MIRT1961799	hsa-miR-302b	CLIP-seq
MIRT1961800	hsa-miR-302c	CLIP-seq
MIRT1961801	hsa-miR-302d	CLIP-seq
MIRT1961802	hsa-miR-302e	CLIP-seq
MIRT883005	hsa-miR-3135b	CLIP-seq
MIRT1961803	hsa-miR-361-5p	CLIP-seq
MIRT883008	hsa-miR-3652	CLIP-seq
MIRT1961804	hsa-miR-372	CLIP-seq
MIRT1961805	hsa-miR-373	CLIP-seq
MIRT883010	hsa-miR-3944-5p	CLIP-seq
MIRT883011	hsa-miR-3973	CLIP-seq
MIRT883013	hsa-miR-4294	CLIP-seq
MIRT883014	hsa-miR-4304	CLIP-seq
MIRT883016	hsa-miR-4430	CLIP-seq
MIRT883017	hsa-miR-4438	CLIP-seq
MIRT1961806	hsa-miR-4494	CLIP-seq
MIRT1961807	hsa-miR-4532	CLIP-seq
MIRT883026	hsa-miR-4713-5p	CLIP-seq
MIRT883027	hsa-miR-4726-3p	CLIP-seq
MIRT1961808	hsa-miR-4731-5p	CLIP-seq
MIRT1961809	hsa-miR-4757-5p	CLIP-seq
MIRT1961810	hsa-miR-498	CLIP-seq
MIRT1961811	hsa-miR-499a-5p	CLIP-seq
MIRT883029	hsa-miR-5095	CLIP-seq
MIRT1961812	hsa-miR-512-3p	CLIP-seq
MIRT1961813	hsa-miR-519d	CLIP-seq
MIRT1961814	hsa-miR-520a-3p	CLIP-seq
MIRT1961815	hsa-miR-520b	CLIP-seq
MIRT1961816	hsa-miR-520c-3p	CLIP-seq
MIRT1961817	hsa-miR-520d-3p	CLIP-seq
MIRT1961818	hsa-miR-520e	CLIP-seq
MIRT883030	hsa-miR-520g	CLIP-seq
MIRT883031	hsa-miR-520h	CLIP-seq
MIRT883032	hsa-miR-532-3p	CLIP-seq
MIRT1961819	hsa-miR-561	CLIP-seq
MIRT1961820	hsa-miR-630	CLIP-seq
MIRT1961821	hsa-miR-643	CLIP-seq
MIRT1961822	hsa-miR-93	CLIP-seq
MIRT2198340	hsa-miR-1200	CLIP-seq
MIRT2198341	hsa-miR-1202	CLIP-seq
MIRT1961789	hsa-miR-1206	CLIP-seq
MIRT882996	hsa-miR-122	CLIP-seq
MIRT883000	hsa-miR-150	CLIP-seq
MIRT2198342	hsa-miR-186	CLIP-seq
MIRT883001	hsa-miR-1915	CLIP-seq
MIRT2198343	hsa-miR-203	CLIP-seq
MIRT2198344	hsa-miR-2276	CLIP-seq
MIRT2198345	hsa-miR-24	CLIP-seq
MIRT2198346	hsa-miR-3133	CLIP-seq
MIRT883005	hsa-miR-3135b	CLIP-seq
MIRT2198347	hsa-miR-3140-5p	CLIP-seq
MIRT2198348	hsa-miR-3173-5p	CLIP-seq
MIRT2198349	hsa-miR-3185	CLIP-seq
MIRT2198350	hsa-miR-362-5p	CLIP-seq
MIRT2198351	hsa-miR-3646	CLIP-seq
MIRT883008	hsa-miR-3652	CLIP-seq
MIRT883010	hsa-miR-3944-5p	CLIP-seq
MIRT2198352	hsa-miR-3972	CLIP-seq
MIRT2198353	hsa-miR-4284	CLIP-seq
MIRT883014	hsa-miR-4304	CLIP-seq
MIRT2198354	hsa-miR-4324	CLIP-seq
MIRT2198355	hsa-miR-4423-5p	CLIP-seq
MIRT883016	hsa-miR-4430	CLIP-seq
MIRT2198356	hsa-miR-4463	CLIP-seq
MIRT2198357	hsa-miR-4466	CLIP-seq
MIRT1961806	hsa-miR-4494	CLIP-seq
MIRT1961807	hsa-miR-4532	CLIP-seq
MIRT883026	hsa-miR-4713-5p	CLIP-seq
MIRT883027	hsa-miR-4726-3p	CLIP-seq
MIRT2198358	hsa-miR-4733-3p	CLIP-seq
MIRT1961810	hsa-miR-498	CLIP-seq
MIRT2198359	hsa-miR-500b	CLIP-seq
MIRT2198360	hsa-miR-501-5p	CLIP-seq
MIRT883032	hsa-miR-532-3p	CLIP-seq
MIRT2198361	hsa-miR-544b	CLIP-seq
MIRT2198362	hsa-miR-675	CLIP-seq
MIRT883003	hsa-miR-2392	CLIP-seq
MIRT2385904	hsa-miR-3674	CLIP-seq
MIRT883017	hsa-miR-4438	CLIP-seq
MIRT1961806	hsa-miR-4494	CLIP-seq
MIRT1961811	hsa-miR-499a-5p	CLIP-seq
MIRT883029	hsa-miR-5095	CLIP-seq
MIRT2198341	hsa-miR-1202	CLIP-seq
MIRT882996	hsa-miR-122	CLIP-seq
MIRT2446794	hsa-miR-1267	CLIP-seq
MIRT2446795	hsa-miR-1289	CLIP-seq
MIRT2446796	hsa-miR-3194-3p	CLIP-seq
MIRT2446797	hsa-miR-3198	CLIP-seq
MIRT2198352	hsa-miR-3972	CLIP-seq
MIRT883013	hsa-miR-4294	CLIP-seq
MIRT2446798	hsa-miR-4309	CLIP-seq
MIRT2446799	hsa-miR-431	CLIP-seq
MIRT2198355	hsa-miR-4423-5p	CLIP-seq
MIRT2198356	hsa-miR-4463	CLIP-seq
MIRT1961806	hsa-miR-4494	CLIP-seq
MIRT1961807	hsa-miR-4532	CLIP-seq
MIRT2446800	hsa-miR-4534	CLIP-seq
MIRT1961810	hsa-miR-498	CLIP-seq
MIRT2446801	hsa-miR-924	CLIP-seq
MIRT1961807	hsa-miR-4532	CLIP-seq
MIRT1961810	hsa-miR-498	CLIP-seq
MIRT2198341	hsa-miR-1202	CLIP-seq
MIRT882996	hsa-miR-122	CLIP-seq
MIRT882998	hsa-miR-129-5p	CLIP-seq
MIRT883000	hsa-miR-150	CLIP-seq
MIRT883001	hsa-miR-1915	CLIP-seq
MIRT883005	hsa-miR-3135b	CLIP-seq
MIRT2501463	hsa-miR-3149	CLIP-seq
MIRT883008	hsa-miR-3652	CLIP-seq
MIRT883010	hsa-miR-3944-5p	CLIP-seq
MIRT2198352	hsa-miR-3972	CLIP-seq
MIRT883014	hsa-miR-4304	CLIP-seq
MIRT2198355	hsa-miR-4423-5p	CLIP-seq
MIRT883016	hsa-miR-4430	CLIP-seq
MIRT2198356	hsa-miR-4463	CLIP-seq
MIRT2198357	hsa-miR-4466	CLIP-seq
MIRT1961806	hsa-miR-4494	CLIP-seq
MIRT1961807	hsa-miR-4532	CLIP-seq
MIRT883026	hsa-miR-4713-5p	CLIP-seq
MIRT883027	hsa-miR-4726-3p	CLIP-seq
MIRT1961810	hsa-miR-498	CLIP-seq
MIRT883032	hsa-miR-532-3p	CLIP-seq
MIRT2198362	hsa-miR-675	CLIP-seq
MIRT882996	hsa-miR-122	CLIP-seq
MIRT882998	hsa-miR-129-5p	CLIP-seq
MIRT883000	hsa-miR-150	CLIP-seq
MIRT883001	hsa-miR-1915	CLIP-seq
MIRT883005	hsa-miR-3135b	CLIP-seq
MIRT2501463	hsa-miR-3149	CLIP-seq
MIRT883008	hsa-miR-3652	CLIP-seq
MIRT883010	hsa-miR-3944-5p	CLIP-seq
MIRT883014	hsa-miR-4304	CLIP-seq
MIRT883016	hsa-miR-4430	CLIP-seq
MIRT1961807	hsa-miR-4532	CLIP-seq
MIRT883026	hsa-miR-4713-5p	CLIP-seq
MIRT883027	hsa-miR-4726-3p	CLIP-seq
MIRT1961810	hsa-miR-498	CLIP-seq
MIRT883032	hsa-miR-532-3p	CLIP-seq

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Transcription factor	Regulation	Reference
USF1	Activation	7876096
USF2	Activation	7876096

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27489282
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IDA	10864933, 10931872
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	3814146
GO:0006915	Process	Apoptotic process	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IMP	2803308
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	2803308
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IC	2803308
GO:0009986	Component	Cell surface	IDA	2317824
GO:0009986	Component	Cell surface	IEA
GO:0010832	Process	Negative regulation of myotube differentiation	IDA	8408226, 10931872
GO:0016020	Component	Membrane	IDA	2317824
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	15052268
GO:0016324	Component	Apical plasma membrane	IDA	10436421
GO:0016324	Component	Apical plasma membrane	IEA
GO:0034109	Process	Homotypic cell-cell adhesion	IDA	10864933
GO:0034235	Function	GPI anchor binding	IMP	10931872
GO:0042802	Function	Identical protein binding	IDA	26483485
GO:0042802	Function	Identical protein binding	IPI	10864933, 18086185, 26483485
GO:0042803	Function	Protein homodimerization activity	IDA	18086185
GO:0043066	Process	Negative regulation of apoptotic process	IDA	11448920
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0098552	Component	Side of membrane	IEA
GO:2000811	Process	Negative regulation of anoikis	IDA	10910050

MIM	HGNC	e!Ensembl
114890	1817	ENSG00000105388

P06731

Protein name

Cell adhesion molecule CEACAM5 (Carcinoembryonic antigen) (CEA) (Carcinoembryonic antigen-related cell adhesion molecule 5) (CEA cell adhesion molecule 5) (Meconium antigen 100) (CD antigen CD66e)

Protein function

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antige

PDB

1E07 , 2QSQ , 2QST , 2VER , 8BW0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	38 → 141	Immunoglobulin V-set domain	Domain
PF13927	Ig_3	146 → 219		Domain
PF13895	Ig_2	239 → 318	Immunoglobulin domain	Domain
PF13927	Ig_3	324 → 397		Domain
PF13895	Ig_2	417 → 496	Immunoglobulin domain	Domain
PF13927	Ig_3	502 → 575		Domain
PF13895	Ig_2	595 → 674	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. {ECO:0000269|PubMed:10436421}.

Sequence

MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ
HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY
TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV
NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP
TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ
AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN
QSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTI
SPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQAN
NSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS
LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP
PDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNL
ATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI

Sequence length

702

Interactions

View interactions

	Reactome
			Post-translational modification: synthesis of GPI-anchored proteins Cell surface interactions at the vascular wall

CEACAM5 (CEA cell adhesion molecule 5)