CLEC10A (C-type lectin domain containing 10A)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10462
Gene name Gene Name - the full gene name approved by the HGNC.
C-type lectin domain containing 10A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CLEC10A
Synonyms (NCBI Gene) Gene synonyms aliases
CD301, CLECSF13, CLECSF14, DC-ASGPR, HML, HML2, MGL
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 32296183, 32766577, 32915505, 33961781, 34015061
GO:0005537 Function D-mannose binding IBA
GO:0005764 Component Lysosome IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605999 16916 ENSG00000132514
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q8IUN9
Protein name C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (DC-asialoglycoprotein receptor) (DC-ASGPR) (Macrophage galactose-type lectin) (MGL) (Macrophage lectin 2) (CD antigen CD301)
Protein function C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs) (PubMed:15802303, PubMed:16998493, PubMed:17616966, PubMed:22213806, PubMed:33724805, PubMed:8598452).
PDB 6PUV , 6PY1 , 6W12 , 6XIY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03954 Lectin_N 12 → 131 Family
PF00059 Lectin_C 198 → 306 Lectin C-type domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in myeloid antigen presenting cells in lymph nodes and skin (at protein level). Expressed in dermal dendritic cells (at protein level). {ECO:0000269|PubMed:16998493, ECO:0000269|PubMed:22213806}.
Sequence
Sequence length 316
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Dectin-2 family
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes, Childhood onset type 2 diabetes, Type 2 diabetes with ketoacidosis (PheCode 250.21) N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Show/Hide Text Mining Associations (42)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
22q11 Deletion Syndrome Associate 18684837
Adenocarcinoma of Lung Associate 33655701
Amyotrophic Lateral Sclerosis Associate 21280084, 33653604, 38383499
Amyotrophic Lateral Sclerosis Stimulate 30068350
Arthritis Juvenile Stimulate 27706807
Arthritis Rheumatoid Associate 19703019, 20345981, 22067224
Atrial Fibrillation Associate 33741890
Autoimmune Diseases Associate 32375827, 34830279
Bipolar Disorder Associate 22253875
Breast Neoplasms Associate 18632860, 22031938, 23873154, 24964007, 25112280, 25951175, 31455323