Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
10451
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Vav guanine nucleotide exchange factor 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
VAV3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
- |
Chromosome
Chromosome number
|
1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
1p13.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product act |
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Autoimmune diseases |
Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 |
rs869025224 |
30595370 |
Glomerulonephritis |
IGA Glomerulonephritis |
rs778043831 |
25305756 |
Hypertension |
Hypertensive disease |
rs13306026 |
21115475 |
Hypothyroidism |
Hypothyroidism |
rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605 View all (22 more) |
22493691, 27182965, 30595370, 30367059 |
Papillary thyroid carcinoma |
Papillary thyroid carcinoma |
rs751409106 |
28703219 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17909013 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Asthma |
Asthma |
|
24388013 |
ClinVar |
Eosinophilia |
Eosinophilia |
|
|
GWAS |
Bipolar Disorder |
Bipolar Disorder |
|
|
GWAS |
Psoriasis |
Psoriasis |
|
|
GWAS |
Inflammatory Bowel Disease |
Inflammatory Bowel Disease |
|
|
GWAS |
Dental caries |
Dental caries |
|
|
GWAS |
Crohn Disease |
Crohn Disease |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Aortic Aneurysm Abdominal |
Associate
|
25993291 |
Breast Neoplasms |
Associate
|
18518979, 20525369, 24886537, 32987507, 40496857 |
Carcinoma Hepatocellular |
Associate
|
29556353 |
Carcinoma Pancreatic Ductal |
Associate
|
26880586 |
Cardiovascular Diseases |
Associate
|
28157227 |
Colorectal Neoplasms |
Associate
|
25791293, 29775793 |
Delayed Cranial Ossification due to CBFB Haploinsufficiency |
Associate
|
19296131 |
Diabetes Mellitus |
Associate
|
28157227 |
Diabetes Mellitus Type 2 |
Associate
|
26337083 |
Glioblastoma |
Associate
|
21649900 |
Glioblastoma |
Stimulate
|
36960857 |
Glomerulonephritis IGA |
Associate
|
37685869 |
Hypertension |
Associate
|
24699462, 28157227 |
Hypothyroidism |
Associate
|
22493691 |
Leukemia |
Associate
|
35650206 |
Leukemia Biphenotypic Acute |
Associate
|
35650206 |
Leukemia Myeloid Acute |
Associate
|
34894858 |
Lymphatic Metastasis |
Associate
|
26695150 |
Lymphoma B Cell |
Associate
|
28811363 |
Lymphoma Non Hodgkin |
Associate
|
29775793 |
Lymphoma T Cell |
Stimulate
|
22510872 |
Myelodysplastic Myeloproliferative Diseases |
Associate
|
28626218 |
Neoplasm Metastasis |
Associate
|
24072493, 25791293 |
Neoplasm Metastasis |
Stimulate
|
25715123 |
Neoplasms |
Associate
|
24072493, 25715123, 26880586, 36960857 |
Neoplasms |
Stimulate
|
26695150 |
Obesity |
Associate
|
28157227 |
Organizing Pneumonia |
Associate
|
28157227 |
Osteitis Deformans |
Associate
|
27172236 |
Ovarian Neoplasms |
Associate
|
25715123 |
Pancreatic Neoplasms |
Associate
|
26337083 |
Prostatic Neoplasms |
Associate
|
18518979, 23023561, 33596994 |
Prostatic Neoplasms Castration Resistant |
Associate
|
23023561, 28811363 |
Psychomotor Disorders |
Associate
|
19296131 |
Schizophrenia |
Associate
|
22416266 |
Stomach Neoplasms |
Associate
|
24072493, 27143812 |
Stomach Neoplasms |
Stimulate
|
26695150 |
Thyroid Neoplasms |
Associate
|
28703219 |
|