Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10451
Gene name Gene Name - the full gene name approved by the HGNC.
Vav guanine nucleotide exchange factor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VAV3
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product act
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016326 hsa-miR-193b-3p Microarray 20304954
MIRT021094 hsa-miR-186-5p Sequencing 20371350
MIRT027493 hsa-miR-98-5p Microarray 19088304
MIRT045501 hsa-miR-149-5p CLASH 23622248
MIRT456110 hsa-miR-28-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001772 Component Immunological synapse IDA 15708849
GO:0005085 Function Guanyl-nucleotide exchange factor activity EXP 8990121
GO:0005085 Function Guanyl-nucleotide exchange factor activity TAS
GO:0005096 Function GTPase activator activity TAS 10523675
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605541 12659 ENSG00000134215
Protein
UniProt ID Q9UKW4
Protein name Guanine nucleotide exchange factor VAV3 (VAV-3)
Protein function Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for
PDB 2D86
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH 1 121 Calponin homology (CH) domain Domain
PF00621 RhoGEF 196 369 RhoGEF domain Domain
PF00169 PH 401 502 PH domain Domain
PF00130 C1_1 514 566 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF07653 SH3_2 596 658 Variant SH3 domain Domain
PF00017 SH2 672 746 SH2 domain Domain
PF07653 SH3_2 793 846 Variant SH3 domain Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bo
Sequence
MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
A
LATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
MKDLAQYVN
EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
EFYCKTKDLKKKWLEQFEMALS
NIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
GYLCFKCGARAHKECLGRVDNCGRVN
SGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPC
PC
VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
ILTRDGFFHIAENRKFKSLMELVEYY
KHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
TYVEED
E
Sequence length 847
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Focal adhesion
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Yersinia infection
Proteoglycans in cancer
Lipid and atherosclerosis
  GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
FCGR3A-mediated phagocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs869025224 30595370
Glomerulonephritis IGA Glomerulonephritis rs778043831 25305756
Hypertension Hypertensive disease rs13306026 21115475
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
22493691, 27182965, 30595370, 30367059
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 24388013 ClinVar
Eosinophilia Eosinophilia GWAS
Bipolar Disorder Bipolar Disorder GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Aortic Aneurysm Abdominal Associate 25993291
Breast Neoplasms Associate 18518979, 20525369, 24886537, 32987507, 40496857
Carcinoma Hepatocellular Associate 29556353
Carcinoma Pancreatic Ductal Associate 26880586
Cardiovascular Diseases Associate 28157227
Colorectal Neoplasms Associate 25791293, 29775793
Delayed Cranial Ossification due to CBFB Haploinsufficiency Associate 19296131
Diabetes Mellitus Associate 28157227
Diabetes Mellitus Type 2 Associate 26337083
Glioblastoma Associate 21649900