Gene Gene information from NCBI Gene database.
Entrez ID 10451
Gene name Vav guanine nucleotide exchange factor 3
Gene symbol VAV3
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1p13.3
Summary This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product act
miRNA miRNA information provided by mirtarbase database.
3003
miRTarBase ID miRNA Experiments Reference
MIRT016326 hsa-miR-193b-3p Microarray 20304954
MIRT021094 hsa-miR-186-5p Sequencing 20371350
MIRT027493 hsa-miR-98-5p Microarray 19088304
MIRT045501 hsa-miR-149-5p CLASH 23622248
MIRT456110 hsa-miR-28-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
46
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001772 Component Immunological synapse IDA 15708849
GO:0002768 Process Immune response-regulating cell surface receptor signaling pathway IBA
GO:0005085 Function Guanyl-nucleotide exchange factor activity EXP 8990121
GO:0005085 Function Guanyl-nucleotide exchange factor activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605541 12659 ENSG00000134215
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UKW4
Protein name Guanine nucleotide exchange factor VAV3 (VAV-3)
Protein function Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for
PDB 2D86
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH 1 121 Calponin homology (CH) domain Domain
PF00621 RhoGEF 196 369 RhoGEF domain Domain
PF00169 PH 401 502 PH domain Domain
PF00130 C1_1 514 566 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF07653 SH3_2 596 658 Variant SH3 domain Domain
PF00017 SH2 672 746 SH2 domain Domain
PF07653 SH3_2 793 846 Variant SH3 domain Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bo
Sequence
MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI
NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI
A
LATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAE
EAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPE
LVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE
DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDA
MKDLAQYVN
EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER
HIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGL
EFYCKTKDLKKKWLEQFEMALS
NIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQ
GYLCFKCGARAHKECLGRVDNCGRVN
SGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVI
RNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPC
PC
VPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIK
ILTRDGFFHIAENRKFKSLMELVEYY
KHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRA
GNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPS
TYVEED
E
Sequence length 847
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Focal adhesion
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Yersinia infection
Proteoglycans in cancer
Lipid and atherosclerosis
  GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
FCGR3A-mediated phagocytosis