Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10449
Gene name Gene Name - the full gene name approved by the HGNC.
Acetyl-CoA acyltransferase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACAA2
Synonyms (NCBI Gene) Gene synonyms aliases
DSAEC, T1
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002662 hsa-miR-124-3p Microarray, qRT-PCR 16549876
MIRT002662 hsa-miR-124-3p Microarray 15685193
MIRT002662 hsa-miR-124-3p Microarray 18668037
MIRT002662 hsa-miR-124-3p qRT-PCR 16549876
MIRT029760 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0003985 Function Acetyl-CoA C-acetyltransferase activity IBA 21873635
GO:0003985 Function Acetyl-CoA C-acetyltransferase activity IDA 25478839
GO:0003986 Function Acetyl-CoA hydrolase activity IEA
GO:0003988 Function Acetyl-CoA C-acyltransferase activity IDA 25478839
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604770 83 ENSG00000167315
Protein
UniProt ID P42765
Protein name 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolas
Protein function In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catal
PDB 4C2J , 4C2K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00108 Thiolase_N 7 266 Thiolase, N-terminal domain Domain
PF02803 Thiolase_C 273 395 Thiolase, C-terminal domain Domain
Sequence
Sequence length 397
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Fatty acid elongation
Fatty acid degradation
Valine, leucine and isoleucine degradation
Metabolic pathways
Fatty acid metabolism
  Mitochondrial Fatty Acid Beta-Oxidation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Unknown
Disease term Disease name Evidence References Source
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Coronary artery disease Coronary artery disease GWAS
Ovarian cancer Ovarian cancer Conditional KD of IL6 in the OCCA xenograft model delays tumor growth GWAS, CBGDA
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Aortic Valve Disease Associate 27250500
Carcinoid Tumor Associate 37798372
Colorectal Neoplasms Associate 37310146
Esophageal Squamous Cell Carcinoma Associate 36162992
Glioma Associate 32280672
Liver Neoplasms Associate 30176945
Lung Neoplasms Associate 37798372
Mitral Valve Insufficiency Associate 27250500
Neuroendocrine Tumors Stimulate 37798372
Prostatic Neoplasms Stimulate 37798372