ACAA2 (acetyl-CoA acyltransferase 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 10449
Gene name Acetyl-CoA acyltransferase 2
Gene symbol ACAA2
Synonyms (NCBI Gene)
DSAECT1
Chromosome 18
Chromosome location 18q21.1
Summary The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
654
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (654)
miRTarBase ID miRNA Experiments Reference
MIRT002662 hsa-miR-124-3p MicroarrayqRT-PCR 16549876
MIRT002662 hsa-miR-124-3p Microarray 15685193
MIRT002662 hsa-miR-124-3p Microarray 18668037
MIRT002662 hsa-miR-124-3p qRT-PCR 16549876
MIRT029760 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (30)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0003985 Function Acetyl-CoA C-acetyltransferase activity IBA
GO:0003985 Function Acetyl-CoA C-acetyltransferase activity IDA 25478839
GO:0003985 Function Acetyl-CoA C-acetyltransferase activity IEA
GO:0003986 Function Acetyl-CoA hydrolase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604770 83 ENSG00000167315
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P42765
Protein name 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolas
Protein function In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catal
PDB 4C2J , 4C2K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00108 Thiolase_N 7 → 266 Thiolase, N-terminal domain Domain
PF02803 Thiolase_C 273 → 395 Thiolase, C-terminal domain Domain
Sequence
Sequence length 397
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Fatty acid elongation
Fatty acid degradation
Valine, leucine and isoleucine degradation
Metabolic pathways
Fatty acid metabolism 		  Mitochondrial Fatty Acid Beta-Oxidation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Malignant tumor of urinary bladder Uncertain significance rs146535277 RCV005927194
Show/Hide Text Mining Associations (13)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Aortic Valve Disease Associate 27250500
Carcinoid Tumor Associate 37798372
Colorectal Neoplasms Associate 37310146
Esophageal Squamous Cell Carcinoma Associate 36162992
Glioma Associate 32280672
Liver Neoplasms Associate 30176945
Lung Neoplasms Associate 37798372
Mitral Valve Insufficiency Associate 27250500
Neuroendocrine Tumors Stimulate 37798372
Prostatic Neoplasms Stimulate 37798372