Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10438
Gene name Gene Name - the full gene name approved by the HGNC.	C1D nuclear receptor corepressor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	C1D
Synonyms (NCBI Gene) Gene synonyms aliases	LRP1, Rrp47, SUN-CoR, SUNCOR, hC1D
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p14
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/

Show/Hide all(215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005157	hsa-miR-30a-5p	pSILAC	18668040
MIRT004148	hsa-miR-192-5p	Microarray	16822819
MIRT024488	hsa-miR-215-5p	Microarray	19074876
MIRT004148	hsa-miR-192-5p	Microarray	19074876
MIRT005157	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT029668	hsa-miR-26b-5p	Microarray	19088304
MIRT724804	hsa-miR-3714	HITS-CLIP	19536157
MIRT724803	hsa-miR-345-3p	HITS-CLIP	19536157
MIRT724802	hsa-miR-4732-3p	HITS-CLIP	19536157
MIRT724801	hsa-miR-125a-5p	HITS-CLIP	19536157
MIRT724800	hsa-miR-125b-5p	HITS-CLIP	19536157
MIRT724799	hsa-miR-4319	HITS-CLIP	19536157
MIRT724798	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT724797	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT724796	hsa-miR-4421	HITS-CLIP	19536157
MIRT724795	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT724794	hsa-miR-4469	HITS-CLIP	19536157
MIRT724793	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT724792	hsa-miR-4287	HITS-CLIP	19536157
MIRT724791	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT724790	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT724789	hsa-miR-4493	HITS-CLIP	19536157
MIRT724788	hsa-miR-4290	HITS-CLIP	19536157
MIRT724787	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT724786	hsa-miR-6811-3p	HITS-CLIP	19536157
MIRT724785	hsa-miR-670-5p	HITS-CLIP	19536157
MIRT724784	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT724783	hsa-miR-6126	HITS-CLIP	19536157
MIRT724782	hsa-miR-6514-3p	HITS-CLIP	19536157
MIRT650391	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT650390	hsa-miR-4258	HITS-CLIP	23824327
MIRT650389	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT491410	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT491409	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT491408	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT491407	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT491406	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT491405	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT491404	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT491403	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT491401	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT491402	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT491400	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT491399	hsa-miR-2355-5p	PAR-CLIP	23592263
MIRT449815	hsa-miR-6500-3p	PAR-CLIP	22100165
MIRT449814	hsa-miR-643	PAR-CLIP	22100165
MIRT449813	hsa-miR-567	PAR-CLIP	22100165
MIRT449812	hsa-miR-675-3p	PAR-CLIP	22100165
MIRT449811	hsa-miR-297	PAR-CLIP	22100165
MIRT449810	hsa-miR-3149	PAR-CLIP	22100165
MIRT724804	hsa-miR-3714	HITS-CLIP	19536157
MIRT724803	hsa-miR-345-3p	HITS-CLIP	19536157
MIRT724802	hsa-miR-4732-3p	HITS-CLIP	19536157
MIRT724801	hsa-miR-125a-5p	HITS-CLIP	19536157
MIRT724800	hsa-miR-125b-5p	HITS-CLIP	19536157
MIRT724799	hsa-miR-4319	HITS-CLIP	19536157
MIRT724798	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT724797	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT724796	hsa-miR-4421	HITS-CLIP	19536157
MIRT724795	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT724794	hsa-miR-4469	HITS-CLIP	19536157
MIRT724793	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT724792	hsa-miR-4287	HITS-CLIP	19536157
MIRT724791	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT724790	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT724789	hsa-miR-4493	HITS-CLIP	19536157
MIRT724788	hsa-miR-4290	HITS-CLIP	19536157
MIRT724787	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT724786	hsa-miR-6811-3p	HITS-CLIP	19536157
MIRT724785	hsa-miR-670-5p	HITS-CLIP	19536157
MIRT724784	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT724783	hsa-miR-6126	HITS-CLIP	19536157
MIRT724782	hsa-miR-6514-3p	HITS-CLIP	19536157
MIRT650391	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT650390	hsa-miR-4258	HITS-CLIP	23824327
MIRT650389	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT491410	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT491409	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT491408	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT491407	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT491406	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT491405	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT491404	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT491403	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT491401	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT491402	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT491400	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT491399	hsa-miR-2355-5p	PAR-CLIP	23592263
MIRT449815	hsa-miR-6500-3p	PAR-CLIP	22100165
MIRT449814	hsa-miR-643	PAR-CLIP	22100165
MIRT449813	hsa-miR-567	PAR-CLIP	22100165
MIRT449812	hsa-miR-675-3p	PAR-CLIP	22100165
MIRT449811	hsa-miR-297	PAR-CLIP	22100165
MIRT449810	hsa-miR-3149	PAR-CLIP	22100165
MIRT839079	hsa-miR-142-5p	CLIP-seq
MIRT839080	hsa-miR-146b-3p	CLIP-seq
MIRT839081	hsa-miR-186	CLIP-seq
MIRT839082	hsa-miR-192	CLIP-seq
MIRT839083	hsa-miR-215	CLIP-seq
MIRT839084	hsa-miR-27a	CLIP-seq
MIRT839085	hsa-miR-27b	CLIP-seq
MIRT839086	hsa-miR-3064-3p	CLIP-seq
MIRT839087	hsa-miR-3133	CLIP-seq
MIRT839088	hsa-miR-3157-3p	CLIP-seq
MIRT839089	hsa-miR-3163	CLIP-seq
MIRT839090	hsa-miR-3173-5p	CLIP-seq
MIRT839091	hsa-miR-3200-3p	CLIP-seq
MIRT839092	hsa-miR-340	CLIP-seq
MIRT839093	hsa-miR-3662	CLIP-seq
MIRT839094	hsa-miR-410	CLIP-seq
MIRT839095	hsa-miR-450a	CLIP-seq
MIRT839096	hsa-miR-4722-3p	CLIP-seq
MIRT839097	hsa-miR-513a-3p	CLIP-seq
MIRT839098	hsa-miR-513a-5p	CLIP-seq
MIRT839099	hsa-miR-520d-5p	CLIP-seq
MIRT839100	hsa-miR-522	CLIP-seq
MIRT839101	hsa-miR-524-5p	CLIP-seq
MIRT839102	hsa-miR-625	CLIP-seq
MIRT839103	hsa-miR-744	CLIP-seq
MIRT839104	hsa-miR-874	CLIP-seq
MIRT839105	hsa-miR-944	CLIP-seq
MIRT839079	hsa-miR-142-5p	CLIP-seq
MIRT839081	hsa-miR-186	CLIP-seq
MIRT839082	hsa-miR-192	CLIP-seq
MIRT839083	hsa-miR-215	CLIP-seq
MIRT839084	hsa-miR-27a	CLIP-seq
MIRT839085	hsa-miR-27b	CLIP-seq
MIRT839087	hsa-miR-3133	CLIP-seq
MIRT839106	hsa-miR-3177-5p	CLIP-seq
MIRT839092	hsa-miR-340	CLIP-seq
MIRT839107	hsa-miR-3606	CLIP-seq
MIRT839094	hsa-miR-410	CLIP-seq
MIRT839108	hsa-miR-4699-3p	CLIP-seq
MIRT839109	hsa-miR-487a	CLIP-seq
MIRT839097	hsa-miR-513a-3p	CLIP-seq
MIRT839098	hsa-miR-513a-5p	CLIP-seq
MIRT839110	hsa-miR-548l	CLIP-seq
MIRT839111	hsa-miR-570	CLIP-seq
MIRT839102	hsa-miR-625	CLIP-seq
MIRT839103	hsa-miR-744	CLIP-seq
MIRT839112	hsa-miR-889	CLIP-seq
MIRT1948792	hsa-miR-1257	CLIP-seq
MIRT839079	hsa-miR-142-5p	CLIP-seq
MIRT839082	hsa-miR-192	CLIP-seq
MIRT839083	hsa-miR-215	CLIP-seq
MIRT839084	hsa-miR-27a	CLIP-seq
MIRT839085	hsa-miR-27b	CLIP-seq
MIRT839087	hsa-miR-3133	CLIP-seq
MIRT839089	hsa-miR-3163	CLIP-seq
MIRT839092	hsa-miR-340	CLIP-seq
MIRT839093	hsa-miR-3662	CLIP-seq
MIRT839094	hsa-miR-410	CLIP-seq
MIRT1948793	hsa-miR-4318	CLIP-seq
MIRT1948794	hsa-miR-4499	CLIP-seq
MIRT839095	hsa-miR-450a	CLIP-seq
MIRT1948795	hsa-miR-4513	CLIP-seq
MIRT1948796	hsa-miR-4693-5p	CLIP-seq
MIRT1948797	hsa-miR-4696	CLIP-seq
MIRT839108	hsa-miR-4699-3p	CLIP-seq
MIRT839097	hsa-miR-513a-3p	CLIP-seq
MIRT839098	hsa-miR-513a-5p	CLIP-seq
MIRT839100	hsa-miR-522	CLIP-seq
MIRT839110	hsa-miR-548l	CLIP-seq
MIRT839102	hsa-miR-625	CLIP-seq
MIRT839103	hsa-miR-744	CLIP-seq
MIRT1948798	hsa-miR-892a	CLIP-seq
MIRT839079	hsa-miR-142-5p	CLIP-seq
MIRT839095	hsa-miR-450a	CLIP-seq
MIRT839102	hsa-miR-625	CLIP-seq
MIRT839103	hsa-miR-744	CLIP-seq
MIRT839095	hsa-miR-450a	CLIP-seq
MIRT839102	hsa-miR-625	CLIP-seq
MIRT839103	hsa-miR-744	CLIP-seq
MIRT839102	hsa-miR-625	CLIP-seq
MIRT839103	hsa-miR-744	CLIP-seq
MIRT2490655	hsa-miR-1270	CLIP-seq
MIRT2490656	hsa-miR-1273f	CLIP-seq
MIRT839079	hsa-miR-142-5p	CLIP-seq
MIRT2490657	hsa-miR-148a	CLIP-seq
MIRT2490658	hsa-miR-148b	CLIP-seq
MIRT2490659	hsa-miR-152	CLIP-seq
MIRT2490660	hsa-miR-185	CLIP-seq
MIRT839081	hsa-miR-186	CLIP-seq
MIRT839082	hsa-miR-192	CLIP-seq
MIRT839083	hsa-miR-215	CLIP-seq
MIRT2490661	hsa-miR-3074-3p	CLIP-seq
MIRT2490662	hsa-miR-3125	CLIP-seq
MIRT839087	hsa-miR-3133	CLIP-seq
MIRT2490663	hsa-miR-335	CLIP-seq
MIRT839092	hsa-miR-340	CLIP-seq
MIRT2490664	hsa-miR-369-3p	CLIP-seq
MIRT2490665	hsa-miR-374a	CLIP-seq
MIRT2490666	hsa-miR-374b	CLIP-seq
MIRT2490667	hsa-miR-3916	CLIP-seq
MIRT839094	hsa-miR-410	CLIP-seq
MIRT2490668	hsa-miR-4306	CLIP-seq
MIRT2490669	hsa-miR-4531	CLIP-seq
MIRT2490670	hsa-miR-4644	CLIP-seq
MIRT2490671	hsa-miR-4668-3p	CLIP-seq
MIRT839110	hsa-miR-548l	CLIP-seq
MIRT2490672	hsa-miR-620	CLIP-seq
MIRT2490673	hsa-miR-9	CLIP-seq
MIRT2490656	hsa-miR-1273f	CLIP-seq
MIRT839079	hsa-miR-142-5p	CLIP-seq
MIRT2490657	hsa-miR-148a	CLIP-seq
MIRT2490658	hsa-miR-148b	CLIP-seq
MIRT2490659	hsa-miR-152	CLIP-seq
MIRT839081	hsa-miR-186	CLIP-seq
MIRT839082	hsa-miR-192	CLIP-seq
MIRT839083	hsa-miR-215	CLIP-seq
MIRT839087	hsa-miR-3133	CLIP-seq
MIRT2490663	hsa-miR-335	CLIP-seq
MIRT839092	hsa-miR-340	CLIP-seq
MIRT839094	hsa-miR-410	CLIP-seq
MIRT2490671	hsa-miR-4668-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000176	Component	Nuclear exosome (RNase complex)	TAS	17412707
GO:0000178	Component	Exosome (RNase complex)	IBA
GO:0000460	Process	Maturation of 5.8S rRNA	IBA
GO:0000460	Process	Maturation of 5.8S rRNA	IMP	17412707
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	9469821
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	17412707
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17412707, 25416956, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9469821
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0016922	Function	Nuclear receptor binding	IEA
GO:0017053	Component	Transcription repressor complex	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA

MIM	HGNC	e!Ensembl
606997	29911	ENSG00000197223

Protein

UniProt ID

Q13901

Protein name

Nuclear nucleic acid-binding protein C1D (hC1D)

Protein function

Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence o

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04000	Sas10_Utp3	17 → 96	Sas10/Utp3/C1D family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appe

Sequence

MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSA
YTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKN
ALWEPKSKNASKVANKGKSKS

Sequence length

141

Interactions

View interactions

	KEGG		Reactome
	RNA degradation		Major pathway of rRNA processing in the nucleolus and cytosol

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Lung adenocarcinoma	Familial lung adenocarcinoma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Meningioma	Associate	20406964
Ovarian Neoplasms	Associate	34995016

C1D (C1D nuclear receptor corepressor)