Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10426
Gene name Gene Name - the full gene name approved by the HGNC.	Tubulin gamma complex component 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TUBGCP3
Synonyms (NCBI Gene) Gene synonyms aliases	104p, ALP6, GCP3, Grip104, SPBC98, Spc98, Spc98p
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q34

Show/Hide all(130)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024502	hsa-miR-215-5p	Microarray	19074876
MIRT026904	hsa-miR-192-5p	Microarray	19074876
MIRT052063	hsa-let-7b-5p	CLASH	23622248
MIRT040911	hsa-miR-18a-3p	CLASH	23622248
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT439374	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT439374	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT1463561	hsa-miR-1197	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT1463563	hsa-miR-1303	CLIP-seq
MIRT1463564	hsa-miR-148a	CLIP-seq
MIRT1463565	hsa-miR-148b	CLIP-seq
MIRT1463566	hsa-miR-152	CLIP-seq
MIRT1463567	hsa-miR-199a-3p	CLIP-seq
MIRT1463568	hsa-miR-199b-3p	CLIP-seq
MIRT1463569	hsa-miR-3124-5p	CLIP-seq
MIRT1463570	hsa-miR-3129-5p	CLIP-seq
MIRT1463571	hsa-miR-3148	CLIP-seq
MIRT1463572	hsa-miR-3202	CLIP-seq
MIRT1463573	hsa-miR-342-3p	CLIP-seq
MIRT1463574	hsa-miR-3613-3p	CLIP-seq
MIRT1463575	hsa-miR-3653	CLIP-seq
MIRT1463576	hsa-miR-3658	CLIP-seq
MIRT1463577	hsa-miR-3661	CLIP-seq
MIRT1463578	hsa-miR-3940-5p	CLIP-seq
MIRT1463579	hsa-miR-3944-5p	CLIP-seq
MIRT1463580	hsa-miR-410	CLIP-seq
MIRT1463581	hsa-miR-4257	CLIP-seq
MIRT1463582	hsa-miR-4259	CLIP-seq
MIRT1463583	hsa-miR-4263	CLIP-seq
MIRT1463584	hsa-miR-4325	CLIP-seq
MIRT1463585	hsa-miR-4436a	CLIP-seq
MIRT1463586	hsa-miR-4436b-3p	CLIP-seq
MIRT1463587	hsa-miR-4484	CLIP-seq
MIRT1463588	hsa-miR-4501	CLIP-seq
MIRT1463589	hsa-miR-4507	CLIP-seq
MIRT1463590	hsa-miR-4695-3p	CLIP-seq
MIRT1463591	hsa-miR-4715-5p	CLIP-seq
MIRT1463592	hsa-miR-4720-3p	CLIP-seq
MIRT1463593	hsa-miR-4799-5p	CLIP-seq
MIRT1463594	hsa-miR-4803	CLIP-seq
MIRT1463595	hsa-miR-491-3p	CLIP-seq
MIRT1463596	hsa-miR-496	CLIP-seq
MIRT1463597	hsa-miR-5096	CLIP-seq
MIRT1463598	hsa-miR-513a-3p	CLIP-seq
MIRT1463599	hsa-miR-520d-5p	CLIP-seq
MIRT1463600	hsa-miR-524-5p	CLIP-seq
MIRT1463601	hsa-miR-545	CLIP-seq
MIRT1463602	hsa-miR-548an	CLIP-seq
MIRT1463603	hsa-miR-568	CLIP-seq
MIRT1463604	hsa-miR-576-5p	CLIP-seq
MIRT1463605	hsa-miR-584	CLIP-seq
MIRT1463606	hsa-miR-586	CLIP-seq
MIRT1463607	hsa-miR-631	CLIP-seq
MIRT1463608	hsa-miR-889	CLIP-seq
MIRT1463609	hsa-miR-936	CLIP-seq
MIRT2139331	hsa-miR-1205	CLIP-seq
MIRT2139332	hsa-miR-1246	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT2139333	hsa-miR-1290	CLIP-seq
MIRT2139334	hsa-miR-130a	CLIP-seq
MIRT2139335	hsa-miR-130b	CLIP-seq
MIRT1463564	hsa-miR-148a	CLIP-seq
MIRT1463565	hsa-miR-148b	CLIP-seq
MIRT1463566	hsa-miR-152	CLIP-seq
MIRT2139336	hsa-miR-187	CLIP-seq
MIRT2139337	hsa-miR-301a	CLIP-seq
MIRT2139338	hsa-miR-301b	CLIP-seq
MIRT2139339	hsa-miR-3074-5p	CLIP-seq
MIRT1463569	hsa-miR-3124-5p	CLIP-seq
MIRT2139340	hsa-miR-3167	CLIP-seq
MIRT1463574	hsa-miR-3613-3p	CLIP-seq
MIRT2139341	hsa-miR-3666	CLIP-seq
MIRT1463578	hsa-miR-3940-5p	CLIP-seq
MIRT2139342	hsa-miR-4274	CLIP-seq
MIRT2139343	hsa-miR-4295	CLIP-seq
MIRT1463584	hsa-miR-4325	CLIP-seq
MIRT1463589	hsa-miR-4507	CLIP-seq
MIRT2139344	hsa-miR-4519	CLIP-seq
MIRT2139345	hsa-miR-454	CLIP-seq
MIRT2139346	hsa-miR-4722-5p	CLIP-seq
MIRT1463599	hsa-miR-520d-5p	CLIP-seq
MIRT1463600	hsa-miR-524-5p	CLIP-seq
MIRT1463603	hsa-miR-568	CLIP-seq
MIRT1463606	hsa-miR-586	CLIP-seq
MIRT2139347	hsa-miR-876-5p	CLIP-seq
MIRT2139348	hsa-miR-891a	CLIP-seq
MIRT2360091	hsa-miR-103a	CLIP-seq
MIRT2360092	hsa-miR-105	CLIP-seq
MIRT2360093	hsa-miR-107	CLIP-seq
MIRT2360094	hsa-miR-1184	CLIP-seq
MIRT1463561	hsa-miR-1197	CLIP-seq
MIRT2139331	hsa-miR-1205	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT1463563	hsa-miR-1303	CLIP-seq
MIRT1463564	hsa-miR-148a	CLIP-seq
MIRT1463565	hsa-miR-148b	CLIP-seq
MIRT1463566	hsa-miR-152	CLIP-seq
MIRT2139339	hsa-miR-3074-5p	CLIP-seq
MIRT2360095	hsa-miR-3162-5p	CLIP-seq
MIRT2360096	hsa-miR-3607-5p	CLIP-seq
MIRT2360097	hsa-miR-4431	CLIP-seq
MIRT1463585	hsa-miR-4436a	CLIP-seq
MIRT1463588	hsa-miR-4501	CLIP-seq
MIRT2139346	hsa-miR-4722-5p	CLIP-seq
MIRT1463599	hsa-miR-520d-5p	CLIP-seq
MIRT1463600	hsa-miR-524-5p	CLIP-seq
MIRT1463606	hsa-miR-586	CLIP-seq
MIRT2360098	hsa-miR-668	CLIP-seq
MIRT2139331	hsa-miR-1205	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT2396493	hsa-miR-3714	CLIP-seq
MIRT1463587	hsa-miR-4484	CLIP-seq
MIRT2139346	hsa-miR-4722-5p	CLIP-seq
MIRT1463594	hsa-miR-4803	CLIP-seq
MIRT1463595	hsa-miR-491-3p	CLIP-seq
MIRT1463602	hsa-miR-548an	CLIP-seq
MIRT2653368	hsa-miR-3163	CLIP-seq
MIRT2653369	hsa-miR-3662	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0000278	Process	Mitotic cell cycle	IBA
GO:0000922	Component	Spindle pole	IEA
GO:0000930	Component	Gamma-tubulin complex	IBA
GO:0005198	Function	Structural molecule activity	NAS	9566967
GO:0005200	Function	Structural constituent of cytoskeleton	NAS	9566969
GO:0005515	Function	Protein binding	IPI	9566969, 17959831
GO:0005737	Component	Cytoplasm	IDA	9566969
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	9566969, 21399614
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	NAS	11694571
GO:0005814	Component	Centriole	IDA	9566969
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005819	Component	Spindle	NAS	7876350
GO:0005827	Component	Polar microtubule	IDA	9566969
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007020	Process	Microtubule nucleation	IBA
GO:0007020	Process	Microtubule nucleation	IEA
GO:0007020	Process	Microtubule nucleation	NAS	9566969, 11694571
GO:0007338	Process	Single fertilization	NAS	9138452
GO:0016020	Component	Membrane	HDA	19946888
GO:0031122	Process	Cytoplasmic microtubule organization	IBA
GO:0043015	Function	Gamma-tubulin binding	IBA
GO:0043015	Function	Gamma-tubulin binding	IDA	9566969
GO:0043015	Function	Gamma-tubulin binding	IEA
GO:0051011	Function	Microtubule minus-end binding	IBA
GO:0051225	Process	Spindle assembly	IBA
GO:0051321	Process	Meiotic cell cycle	IBA

MIM	HGNC	e!Ensembl
617818	18598	ENSG00000126216

Protein

UniProt ID

Q96CW5

Protein name

Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98)

Protein function

Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809, PubMed:9566967). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that g

PDB

6V6B , 6V6S , 6X0U , 7AS4 , 7QJ0 , 7QJ1 , 7QJ2 , 7QJ3 , 7QJ4 , 7QJ5 , 7QJ6 , 7QJ7 , 7QJ8 , 7QJ9 , 7QJA , 7QJB , 7QJC , 7QJD , 8Q62 , 8RX1 , 8VRD , 8VRJ , 8VRK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17681	GCP_N_terminal	251 → 552	Gamma tubulin complex component N-terminal	Domain
PF04130	GCP_C_terminal	555 → 886	Gamma tubulin complex component C-terminal	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQ
ALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSL
LPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTG
GTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWL
HNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLES
SLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILS
LVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQS
RKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFE
TSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGI
LETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHY
LRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQY
YITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFD
QIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESI
PKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTR
GRRSSHT

Sequence length

907

Interactions

View interactions

	Reactome
			Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Hyperglycemia	Associate	20858683

TUBGCP3 (tubulin gamma complex component 3)