Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10426
Gene name	Tubulin gamma complex component 3
Gene symbol	TUBGCP3
Synonyms (NCBI Gene)	104pALP6GCP3Grip104SPBC98Spc98Spc98p
Chromosome	13
Chromosome location	13q34

130

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024502	hsa-miR-215-5p	Microarray	19074876
MIRT026904	hsa-miR-192-5p	Microarray	19074876
MIRT052063	hsa-let-7b-5p	CLASH	23622248
MIRT040911	hsa-miR-18a-3p	CLASH	23622248
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT439374	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT439374	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT719623	hsa-miR-4699-3p	HITS-CLIP	19536157
MIRT719622	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719621	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT1463561	hsa-miR-1197	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT1463563	hsa-miR-1303	CLIP-seq
MIRT1463564	hsa-miR-148a	CLIP-seq
MIRT1463565	hsa-miR-148b	CLIP-seq
MIRT1463566	hsa-miR-152	CLIP-seq
MIRT1463567	hsa-miR-199a-3p	CLIP-seq
MIRT1463568	hsa-miR-199b-3p	CLIP-seq
MIRT1463569	hsa-miR-3124-5p	CLIP-seq
MIRT1463570	hsa-miR-3129-5p	CLIP-seq
MIRT1463571	hsa-miR-3148	CLIP-seq
MIRT1463572	hsa-miR-3202	CLIP-seq
MIRT1463573	hsa-miR-342-3p	CLIP-seq
MIRT1463574	hsa-miR-3613-3p	CLIP-seq
MIRT1463575	hsa-miR-3653	CLIP-seq
MIRT1463576	hsa-miR-3658	CLIP-seq
MIRT1463577	hsa-miR-3661	CLIP-seq
MIRT1463578	hsa-miR-3940-5p	CLIP-seq
MIRT1463579	hsa-miR-3944-5p	CLIP-seq
MIRT1463580	hsa-miR-410	CLIP-seq
MIRT1463581	hsa-miR-4257	CLIP-seq
MIRT1463582	hsa-miR-4259	CLIP-seq
MIRT1463583	hsa-miR-4263	CLIP-seq
MIRT1463584	hsa-miR-4325	CLIP-seq
MIRT1463585	hsa-miR-4436a	CLIP-seq
MIRT1463586	hsa-miR-4436b-3p	CLIP-seq
MIRT1463587	hsa-miR-4484	CLIP-seq
MIRT1463588	hsa-miR-4501	CLIP-seq
MIRT1463589	hsa-miR-4507	CLIP-seq
MIRT1463590	hsa-miR-4695-3p	CLIP-seq
MIRT1463591	hsa-miR-4715-5p	CLIP-seq
MIRT1463592	hsa-miR-4720-3p	CLIP-seq
MIRT1463593	hsa-miR-4799-5p	CLIP-seq
MIRT1463594	hsa-miR-4803	CLIP-seq
MIRT1463595	hsa-miR-491-3p	CLIP-seq
MIRT1463596	hsa-miR-496	CLIP-seq
MIRT1463597	hsa-miR-5096	CLIP-seq
MIRT1463598	hsa-miR-513a-3p	CLIP-seq
MIRT1463599	hsa-miR-520d-5p	CLIP-seq
MIRT1463600	hsa-miR-524-5p	CLIP-seq
MIRT1463601	hsa-miR-545	CLIP-seq
MIRT1463602	hsa-miR-548an	CLIP-seq
MIRT1463603	hsa-miR-568	CLIP-seq
MIRT1463604	hsa-miR-576-5p	CLIP-seq
MIRT1463605	hsa-miR-584	CLIP-seq
MIRT1463606	hsa-miR-586	CLIP-seq
MIRT1463607	hsa-miR-631	CLIP-seq
MIRT1463608	hsa-miR-889	CLIP-seq
MIRT1463609	hsa-miR-936	CLIP-seq
MIRT2139331	hsa-miR-1205	CLIP-seq
MIRT2139332	hsa-miR-1246	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT2139333	hsa-miR-1290	CLIP-seq
MIRT2139334	hsa-miR-130a	CLIP-seq
MIRT2139335	hsa-miR-130b	CLIP-seq
MIRT1463564	hsa-miR-148a	CLIP-seq
MIRT1463565	hsa-miR-148b	CLIP-seq
MIRT1463566	hsa-miR-152	CLIP-seq
MIRT2139336	hsa-miR-187	CLIP-seq
MIRT2139337	hsa-miR-301a	CLIP-seq
MIRT2139338	hsa-miR-301b	CLIP-seq
MIRT2139339	hsa-miR-3074-5p	CLIP-seq
MIRT1463569	hsa-miR-3124-5p	CLIP-seq
MIRT2139340	hsa-miR-3167	CLIP-seq
MIRT1463574	hsa-miR-3613-3p	CLIP-seq
MIRT2139341	hsa-miR-3666	CLIP-seq
MIRT1463578	hsa-miR-3940-5p	CLIP-seq
MIRT2139342	hsa-miR-4274	CLIP-seq
MIRT2139343	hsa-miR-4295	CLIP-seq
MIRT1463584	hsa-miR-4325	CLIP-seq
MIRT1463589	hsa-miR-4507	CLIP-seq
MIRT2139344	hsa-miR-4519	CLIP-seq
MIRT2139345	hsa-miR-454	CLIP-seq
MIRT2139346	hsa-miR-4722-5p	CLIP-seq
MIRT1463599	hsa-miR-520d-5p	CLIP-seq
MIRT1463600	hsa-miR-524-5p	CLIP-seq
MIRT1463603	hsa-miR-568	CLIP-seq
MIRT1463606	hsa-miR-586	CLIP-seq
MIRT2139347	hsa-miR-876-5p	CLIP-seq
MIRT2139348	hsa-miR-891a	CLIP-seq
MIRT2360091	hsa-miR-103a	CLIP-seq
MIRT2360092	hsa-miR-105	CLIP-seq
MIRT2360093	hsa-miR-107	CLIP-seq
MIRT2360094	hsa-miR-1184	CLIP-seq
MIRT1463561	hsa-miR-1197	CLIP-seq
MIRT2139331	hsa-miR-1205	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT1463563	hsa-miR-1303	CLIP-seq
MIRT1463564	hsa-miR-148a	CLIP-seq
MIRT1463565	hsa-miR-148b	CLIP-seq
MIRT1463566	hsa-miR-152	CLIP-seq
MIRT2139339	hsa-miR-3074-5p	CLIP-seq
MIRT2360095	hsa-miR-3162-5p	CLIP-seq
MIRT2360096	hsa-miR-3607-5p	CLIP-seq
MIRT2360097	hsa-miR-4431	CLIP-seq
MIRT1463585	hsa-miR-4436a	CLIP-seq
MIRT1463588	hsa-miR-4501	CLIP-seq
MIRT2139346	hsa-miR-4722-5p	CLIP-seq
MIRT1463599	hsa-miR-520d-5p	CLIP-seq
MIRT1463600	hsa-miR-524-5p	CLIP-seq
MIRT1463606	hsa-miR-586	CLIP-seq
MIRT2360098	hsa-miR-668	CLIP-seq
MIRT2139331	hsa-miR-1205	CLIP-seq
MIRT1463562	hsa-miR-1286	CLIP-seq
MIRT2396493	hsa-miR-3714	CLIP-seq
MIRT1463587	hsa-miR-4484	CLIP-seq
MIRT2139346	hsa-miR-4722-5p	CLIP-seq
MIRT1463594	hsa-miR-4803	CLIP-seq
MIRT1463595	hsa-miR-491-3p	CLIP-seq
MIRT1463602	hsa-miR-548an	CLIP-seq
MIRT2653368	hsa-miR-3163	CLIP-seq
MIRT2653369	hsa-miR-3662	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0000278	Process	Mitotic cell cycle	IBA
GO:0000922	Component	Spindle pole	IEA
GO:0000930	Component	Gamma-tubulin complex	IBA
GO:0005198	Function	Structural molecule activity	NAS	9566967
GO:0005200	Function	Structural constituent of cytoskeleton	NAS	9566969
GO:0005515	Function	Protein binding	IPI	9566969, 17959831
GO:0005737	Component	Cytoplasm	IDA	9566969
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	9566969, 21399614
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	NAS	11694571
GO:0005814	Component	Centriole	IDA	9566969
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005819	Component	Spindle	NAS	7876350
GO:0005827	Component	Polar microtubule	IDA	9566969
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007020	Process	Microtubule nucleation	IBA
GO:0007020	Process	Microtubule nucleation	IEA
GO:0007020	Process	Microtubule nucleation	NAS	9566969, 11694571
GO:0007338	Process	Single fertilization	NAS	9138452
GO:0016020	Component	Membrane	HDA	19946888
GO:0031122	Process	Cytoplasmic microtubule organization	IBA
GO:0043015	Function	Gamma-tubulin binding	IBA
GO:0043015	Function	Gamma-tubulin binding	IDA	9566969
GO:0043015	Function	Gamma-tubulin binding	IEA
GO:0051011	Function	Microtubule minus-end binding	IBA
GO:0051225	Process	Spindle assembly	IBA
GO:0051321	Process	Meiotic cell cycle	IBA

MIM	HGNC	e!Ensembl
617818	18598	ENSG00000126216

Q96CW5

Protein name

Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98)

Protein function

Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809, PubMed:9566967). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that g

PDB

6V6B , 6V6S , 6X0U , 7AS4 , 7QJ0 , 7QJ1 , 7QJ2 , 7QJ3 , 7QJ4 , 7QJ5 , 7QJ6 , 7QJ7 , 7QJ8 , 7QJ9 , 7QJA , 7QJB , 7QJC , 7QJD , 8Q62 , 8RX1 , 8VRD , 8VRJ , 8VRK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17681	GCP_N_terminal	251 → 552	Gamma tubulin complex component N-terminal	Domain
PF04130	GCP_C_terminal	555 → 886	Gamma tubulin complex component C-terminal	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQ
ALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSL
LPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTG
GTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWL
HNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLES
SLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILS
LVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQS
RKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFE
TSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGI
LETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHY
LRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQY
YITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFD
QIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESI
PKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTR
GRRSSHT

Sequence length

907

Interactions

View interactions

	Reactome
			Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Lung cancer	Uncertain significance	rs142074295	RCV005932286
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs142074295	RCV005932285

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Hyperglycemia	Associate	20858683

TUBGCP3 (tubulin gamma complex component 3)