TESK2 (testis associated actin remodelling kinase 2)

Gene

• Entrez ID: 10420
• Gene name: Testis associated actin remodelling kinase 2
• Gene symbol: TESK2
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p34.1
• Summary: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overa

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021469	hsa-miR-9-5p	Microarray	17612493
MIRT031008	hsa-miR-21-5p	Microarray	18591254
MIRT038778	hsa-miR-93-3p	CLASH	23622248
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	20371350
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	20371350
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	20371350
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	20371350
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	20371350
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	20371350
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	20371350
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	20371350
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	20371350
MIRT488212	hsa-miR-485-3p	PAR-CLIP	20371350
MIRT488211	hsa-miR-539-3p	PAR-CLIP	20371350
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	20371350
MIRT512865	hsa-miR-6768-5p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23446348
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23446348
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23446348
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23446348
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23446348
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	23446348
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	23446348
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	23446348
MIRT512861	hsa-miR-4672	PAR-CLIP	23446348
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23446348
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23446348
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23592263
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23592263
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23592263
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23592263
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23592263
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	20371350
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	20371350
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	20371350
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	20371350
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	20371350
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	20371350
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	20371350
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	20371350
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	20371350
MIRT488212	hsa-miR-485-3p	PAR-CLIP	20371350
MIRT488211	hsa-miR-539-3p	PAR-CLIP	20371350
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	20371350
MIRT512865	hsa-miR-6768-5p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23446348
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23446348
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23446348
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23446348
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23446348
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	23446348
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	23446348
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	23446348
MIRT512861	hsa-miR-4672	PAR-CLIP	23446348
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23446348
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23446348
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23592263
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23592263
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23592263
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23592263
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23592263
MIRT1418510	hsa-miR-1207-3p	CLIP-seq
MIRT1418511	hsa-miR-1207-5p	CLIP-seq
MIRT1418512	hsa-miR-130a	CLIP-seq
MIRT1418513	hsa-miR-130b	CLIP-seq
MIRT1418514	hsa-miR-142-3p	CLIP-seq
MIRT1418515	hsa-miR-1910	CLIP-seq
MIRT1418516	hsa-miR-19a	CLIP-seq
MIRT1418517	hsa-miR-19b	CLIP-seq
MIRT1418518	hsa-miR-2110	CLIP-seq
MIRT1418519	hsa-miR-2114	CLIP-seq
MIRT1418520	hsa-miR-301a	CLIP-seq
MIRT1418521	hsa-miR-301b	CLIP-seq
MIRT1418522	hsa-miR-302a	CLIP-seq
MIRT1418523	hsa-miR-302b	CLIP-seq
MIRT1418524	hsa-miR-302c	CLIP-seq
MIRT1418525	hsa-miR-302d	CLIP-seq
MIRT1418526	hsa-miR-302e	CLIP-seq
MIRT1418527	hsa-miR-31	CLIP-seq
MIRT1418528	hsa-miR-3120-3p	CLIP-seq
MIRT1418529	hsa-miR-3121-3p	CLIP-seq
MIRT1418530	hsa-miR-3133	CLIP-seq
MIRT1418531	hsa-miR-3153	CLIP-seq
MIRT1418532	hsa-miR-3202	CLIP-seq
MIRT1418533	hsa-miR-339-5p	CLIP-seq
MIRT1418534	hsa-miR-340	CLIP-seq
MIRT1418535	hsa-miR-342-5p	CLIP-seq
MIRT1418536	hsa-miR-3647-3p	CLIP-seq
MIRT1418537	hsa-miR-3661	CLIP-seq
MIRT1418538	hsa-miR-3666	CLIP-seq
MIRT1418539	hsa-miR-372	CLIP-seq
MIRT1418540	hsa-miR-373	CLIP-seq
MIRT1418541	hsa-miR-421	CLIP-seq
MIRT1418542	hsa-miR-4256	CLIP-seq
MIRT1418543	hsa-miR-4271	CLIP-seq
MIRT1418544	hsa-miR-4275	CLIP-seq
MIRT1418545	hsa-miR-4295	CLIP-seq
MIRT1418546	hsa-miR-4476	CLIP-seq
MIRT1418547	hsa-miR-4517	CLIP-seq
MIRT1418548	hsa-miR-4527	CLIP-seq
MIRT1418549	hsa-miR-454	CLIP-seq
MIRT1418550	hsa-miR-455-3p	CLIP-seq
MIRT1418551	hsa-miR-4651	CLIP-seq
MIRT1418552	hsa-miR-4655-5p	CLIP-seq
MIRT1418553	hsa-miR-4664-5p	CLIP-seq
MIRT1418554	hsa-miR-4709-5p	CLIP-seq
MIRT1418555	hsa-miR-4725-3p	CLIP-seq
MIRT1418556	hsa-miR-4736	CLIP-seq
MIRT1418557	hsa-miR-4763-3p	CLIP-seq
MIRT1418558	hsa-miR-491-5p	CLIP-seq
MIRT1418559	hsa-miR-493	CLIP-seq
MIRT1418560	hsa-miR-519a	CLIP-seq
MIRT1418561	hsa-miR-519b-3p	CLIP-seq
MIRT1418562	hsa-miR-519c-3p	CLIP-seq
MIRT1418563	hsa-miR-520a-3p	CLIP-seq
MIRT1418564	hsa-miR-520b	CLIP-seq
MIRT1418565	hsa-miR-520c-3p	CLIP-seq
MIRT1418566	hsa-miR-520d-3p	CLIP-seq
MIRT1418567	hsa-miR-520e	CLIP-seq
MIRT1418568	hsa-miR-548b-3p	CLIP-seq
MIRT1418569	hsa-miR-548c-3p	CLIP-seq
MIRT1418570	hsa-miR-568	CLIP-seq
MIRT1418571	hsa-miR-584	CLIP-seq
MIRT1418572	hsa-miR-591	CLIP-seq
MIRT1418573	hsa-miR-608	CLIP-seq
MIRT1418574	hsa-miR-631	CLIP-seq
MIRT1418575	hsa-miR-766	CLIP-seq
MIRT1418576	hsa-miR-888	CLIP-seq
MIRT1418514	hsa-miR-142-3p	CLIP-seq
MIRT2125522	hsa-miR-153	CLIP-seq
MIRT2125523	hsa-miR-383	CLIP-seq
MIRT2125524	hsa-miR-4436b-5p	CLIP-seq
MIRT2125525	hsa-miR-448	CLIP-seq
MIRT2125526	hsa-miR-4716-5p	CLIP-seq
MIRT2125527	hsa-miR-4772-5p	CLIP-seq
MIRT2347870	hsa-miR-1182	CLIP-seq
MIRT2347871	hsa-miR-1247	CLIP-seq
MIRT2347872	hsa-miR-1287	CLIP-seq
MIRT2347873	hsa-miR-1290	CLIP-seq
MIRT1418512	hsa-miR-130a	CLIP-seq
MIRT1418513	hsa-miR-130b	CLIP-seq
MIRT2347874	hsa-miR-1827	CLIP-seq
MIRT1418515	hsa-miR-1910	CLIP-seq
MIRT1418516	hsa-miR-19a	CLIP-seq
MIRT1418517	hsa-miR-19b	CLIP-seq
MIRT1418520	hsa-miR-301a	CLIP-seq
MIRT1418521	hsa-miR-301b	CLIP-seq
MIRT1418522	hsa-miR-302a	CLIP-seq
MIRT1418523	hsa-miR-302b	CLIP-seq
MIRT1418524	hsa-miR-302c	CLIP-seq
MIRT1418525	hsa-miR-302d	CLIP-seq
MIRT1418526	hsa-miR-302e	CLIP-seq
MIRT1418528	hsa-miR-3120-3p	CLIP-seq
MIRT1418531	hsa-miR-3153	CLIP-seq
MIRT2347875	hsa-miR-3167	CLIP-seq
MIRT2347876	hsa-miR-3188	CLIP-seq
MIRT1418532	hsa-miR-3202	CLIP-seq
MIRT2347877	hsa-miR-3612	CLIP-seq
MIRT1418538	hsa-miR-3666	CLIP-seq
MIRT2347878	hsa-miR-3689a-3p	CLIP-seq
MIRT2347879	hsa-miR-3689c	CLIP-seq
MIRT1418539	hsa-miR-372	CLIP-seq
MIRT1418540	hsa-miR-373	CLIP-seq
MIRT2347880	hsa-miR-3942-3p	CLIP-seq
MIRT2347881	hsa-miR-4257	CLIP-seq
MIRT1418544	hsa-miR-4275	CLIP-seq
MIRT1418545	hsa-miR-4295	CLIP-seq
MIRT2347882	hsa-miR-4299	CLIP-seq
MIRT2347883	hsa-miR-4456	CLIP-seq
MIRT1418546	hsa-miR-4476	CLIP-seq
MIRT1418549	hsa-miR-454	CLIP-seq
MIRT1418550	hsa-miR-455-3p	CLIP-seq
MIRT2347884	hsa-miR-4728-5p	CLIP-seq
MIRT1418560	hsa-miR-519a	CLIP-seq
MIRT1418561	hsa-miR-519b-3p	CLIP-seq
MIRT1418562	hsa-miR-519c-3p	CLIP-seq
MIRT1418563	hsa-miR-520a-3p	CLIP-seq
MIRT1418564	hsa-miR-520b	CLIP-seq
MIRT1418565	hsa-miR-520c-3p	CLIP-seq
MIRT1418566	hsa-miR-520d-3p	CLIP-seq
MIRT1418567	hsa-miR-520e	CLIP-seq
MIRT2347885	hsa-miR-541	CLIP-seq
MIRT2347886	hsa-miR-548q	CLIP-seq
MIRT2347887	hsa-miR-650	CLIP-seq
MIRT2347888	hsa-miR-654-5p	CLIP-seq
MIRT2347889	hsa-miR-876-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	10512679
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 32707033, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0006468	Process	Protein phosphorylation	ISS
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007283	Process	Spermatogenesis	TAS	10512679
GO:0016301	Function	Kinase activity	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048041	Process	Focal adhesion assembly	IEA
GO:0048041	Process	Focal adhesion assembly	ISS
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 604746
• HGNC: 11732
• e!Ensembl: ENSG00000070759

Protein

• UniProt ID: Q96S53
• Protein name: Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)
• Protein function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07714	PK_Tyr_Ser-Thr	59 → 309	Protein tyrosine and serine/threonine kinase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells. {ECO:0000269|PubMed:10512679, ECO:0000269|PubMed:11418599}.
• Sequence:

  MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT
  CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC
  VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK
  NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF
  SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP
  SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR
  TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS
  KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD
  GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE
  EMEVEERPAGSTPATFSTSGIGLQTQGKQDG

• Sequence length: 571