Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10399
Gene name Gene Name - the full gene name approved by the HGNC.	Receptor for activated C kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RACK1
Synonyms (NCBI Gene) Gene synonyms aliases	GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q35.3

Show/Hide all(100)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001891	Component	Phagocytic cup	IDA	21347310
GO:0001891	Component	Phagocytic cup	IEA
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	11312657, 17108144
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005080	Function	Protein kinase C binding	IBA
GO:0005080	Function	Protein kinase C binding	IDA	11279199
GO:0005102	Function	Signaling receptor binding	NAS	12809483
GO:0005515	Function	Protein binding	IPI	10849009, 11046044, 11279199, 11312657, 12809483, 14500341, 17108144, 18057008, 18194455, 18420585, 18816594, 18954305, 19674157, 19785988, 20010870, 20080539, 20103773, 20541605, 20871634, 21098120, 21146485, 21347310, 21525958, 21750715, 21988832, 22210188, 23651062, 23866081, 240
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10849009, 17108144
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	10849009, 19785988, 29743600
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005739	Component	Mitochondrion	IMP	19767770
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IMP	19767770
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006412	Process	Translation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007369	Process	Gastrulation	IEA
GO:0008047	Function	Enzyme activator activity	IDA	20819076
GO:0008200	Function	Ion channel inhibitor activity	IEA
GO:0008200	Function	Ion channel inhibitor activity	ISS
GO:0008656	Function	Cysteine-type endopeptidase activator activity involved in apoptotic process	IMP	19767770
GO:0010629	Process	Negative regulation of gene expression	IMP	19451233
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0015935	Component	Small ribosomal subunit	ISS
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IMP	28132843
GO:0017148	Process	Negative regulation of translation	ISS
GO:0019899	Function	Enzyme binding	IPI	20819076
GO:0019903	Function	Protein phosphatase binding	IPI	11278757
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0030178	Process	Negative regulation of Wnt signaling pathway	ISS
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	IMP	20103773
GO:0030292	Function	Protein tyrosine kinase inhibitor activity	IDA	9584165
GO:0030308	Process	Negative regulation of cell growth	IDA	9584165
GO:0030332	Function	Cyclin binding	IPI	15159402
GO:0030335	Process	Positive regulation of cell migration	IDA	20499158
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0030496	Component	Midbody	IDA	15166316
GO:0030971	Function	Receptor tyrosine kinase binding	IDA	9584165
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IDA	20541605
GO:0032091	Process	Negative regulation of protein binding	IDA	20541605
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	19785988
GO:0032880	Process	Regulation of protein localization	ISS
GO:0035591	Function	Signaling adaptor activity	IMP	20103773
GO:0042169	Function	SH2 domain binding	IDA	9584165, 11279199
GO:0042802	Function	Identical protein binding	IPI	24947010, 35271311
GO:0042803	Function	Protein homodimerization activity	IPI	24947010
GO:0042995	Component	Cell projection	IEA
GO:0042998	Process	Positive regulation of Golgi to plasma membrane protein transport	IMP	19674157
GO:0043005	Component	Neuron projection	IEA
GO:0043022	Function	Ribosome binding	IBA
GO:0043022	Function	Ribosome binding	IDA	28132843
GO:0043022	Function	Ribosome binding	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043025	Component	Neuronal cell body	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	20541605
GO:0043065	Process	Positive regulation of apoptotic process	IMP	19767770
GO:0043204	Component	Perikaryon	IEA
GO:0043473	Process	Pigmentation	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	20499158
GO:0044297	Component	Cell body	IEA
GO:0045182	Function	Translation regulator activity	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045879	Process	Negative regulation of smoothened signaling pathway	IDA	32467643
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	11279199
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0050765	Process	Negative regulation of phagocytosis	IMP	21347310
GO:0051302	Process	Regulation of cell division	ISS
GO:0051434	Function	BH3 domain binding	IDA	20541605
GO:0051726	Process	Regulation of cell cycle	IDA	9584165
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	19767770
GO:0051901	Process	Positive regulation of mitochondrial depolarization	IMP	19767770
GO:0060090	Function	Molecular adaptor activity	TAS	20819076
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071333	Process	Cellular response to glucose stimulus	IDA	20103773
GO:0071363	Process	Cellular response to growth factor stimulus	IDA	20010870
GO:0072344	Process	Rescue of stalled ribosome	IBA
GO:0072344	Process	Rescue of stalled ribosome	IMP	28132843
GO:0106070	Process	Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	20819076
GO:1900102	Process	Negative regulation of endoplasmic reticulum unfolded protein response	TAS	22013210
GO:1903751	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IEA
GO:1903751	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IGI	24947010
GO:1990630	Component	IRE1-RACK1-PP2A complex	IDA	20103773
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:2000114	Process	Regulation of establishment of cell polarity	ISS
GO:2000543	Process	Positive regulation of gastrulation	ISS
GO:2001125	Process	Negative regulation of translational frameshifting	IBA
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IMP	19767770

MIM	HGNC	e!Ensembl
176981	4399	ENSG00000204628

Protein

UniProt ID

P63244

Protein name

Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-

Protein function

Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involv

PDB

4AOW , 4UG0 , 4V5Z , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	5 → 44	WD domain, G-beta repeat	Repeat
PF00400	WD40	53 → 91	WD domain, G-beta repeat	Repeat
PF00400	WD40	95 → 133	WD domain, G-beta repeat	Repeat
PF00400	WD40	136 → 178	WD domain, G-beta repeat	Repeat
PF00400	WD40	182 → 220	WD domain, G-beta repeat	Repeat
PF00400	WD40	224 → 260	WD domain, G-beta repeat	Repeat
PF00400	WD40	273 → 311	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. {ECO:0000269|PubMed:18621736}.

Sequence

MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR
GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI
VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC
FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA
GYTDNLVRVWQVTIGTR

Sequence length

317

Interactions

View interactions

	KEGG		Reactome
	Measles		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Neurodevelopmental Disorders	neurodevelopmental disorder	N/A	N/A	GenCC

Show/Hide Text Mining Associations (55)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Amyotrophic Lateral Sclerosis	Associate	28158562
Autism Spectrum Disorder	Associate	36646776
Autistic Disorder	Associate	36646776
Breast Neoplasms	Associate	22355776, 27600565, 27754360, 31113938
Carcinogenesis	Associate	18458027, 29048616, 33537079, 34611296, 35101055, 37828084
Carcinoma Hepatocellular	Associate	18621736, 28396991
Carcinoma Hepatocellular	Inhibit	34657150
Carcinoma Non Small Cell Lung	Associate	25686824, 26462029, 28371058, 28465488, 33537079, 35101055
Carcinoma Renal Cell	Associate	17760843
Chemical and Drug Induced Liver Injury	Associate	18621736
Colorectal Neoplasms	Associate	11836445, 19855191, 30451832, 37519194
Death	Associate	26462029
Diarrhea 5 With Tufting Enteropathy Congenital	Stimulate	18458027
Endocrine System Diseases	Associate	36646776
Endometrial Neoplasms	Associate	30352458
Endometriosis	Associate	30352458
Esophageal Squamous Cell Carcinoma	Associate	25719728
Fragile X Syndrome	Associate	37820724
Glioma	Associate	27763568
HIV Infections	Associate	39405943
Hypertension Pulmonary	Associate	11282888
Hypoxia	Associate	32215176
Leukoplakia	Associate	37507024
Leukoplakia Oral	Associate	37507024
Lung Neoplasms	Associate	28465488
Lupus Erythematosus Systemic	Associate	36114579
Lymphatic Metastasis	Associate	25719728
Lymphatic Metastasis	Stimulate	30451832, 35616137
Lymphedema Hereditary IB	Associate	28371058
Melanoma	Associate	17482134
Mitochondrial Diseases	Associate	37820724
Nasopharyngeal Carcinoma	Associate	27170279
Neoplasm Metastasis	Associate	18458027, 27170279, 27763568, 28797110, 37519194
Neoplasms	Associate	17760843, 18567578, 20441585, 20493699, 25719728, 27170279, 27600565, 27754360, 27763568, 29048616, 30451832, 37638009
Neoplasms	Stimulate	18458027, 34326696
Neoplasms	Inhibit	27453417
Neuroblastoma	Associate	28158562
Neurologic Manifestations	Associate	36691005
Osteosarcoma	Associate	37591850
Ovarian Neoplasms	Associate	37828084
Peri Implantitis	Stimulate	30352458
Precancerous Conditions	Stimulate	30451832
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	27644318
Prostatic Neoplasms	Associate	22378065, 34082608
Prostatic stromal proliferation of uncertain malignant potential	Associate	37507024
Pulmonary Disease Chronic Obstructive	Associate	31601710
Sarcoma Kaposi	Associate	40016701
Squamous Cell Carcinoma of Head and Neck	Associate	18458027
Stomach Neoplasms	Inhibit	27453417
Stomach Neoplasms	Associate	28797110, 37443145
Tertiary Lymphoid Structures	Stimulate	18458027
Tertiary Lymphoid Structures	Associate	27170279
Uterine Cervical Neoplasms	Stimulate	29048616
Uterine Cervical Neoplasms	Associate	35616137, 36658304
Werner Syndrome	Associate	19966859

RACK1 (receptor for activated C kinase 1)