Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10392
Gene name Gene Name - the full gene name approved by the HGNC.	Nucleotide binding oligomerization domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NOD1
Synonyms (NCBI Gene) Gene synonyms aliases	CARD4, CLR7.1, NLRC1, hNod1
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p14.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidogly

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miRTarBase ID	miRNA	Experiments	Reference
MIRT735303	hsa-miR-298	Luciferase reporter assay, qRT-PCR, ELISA	32353008
MIRT1188272	hsa-miR-103a	CLIP-seq
MIRT1188273	hsa-miR-107	CLIP-seq
MIRT1188274	hsa-miR-1183	CLIP-seq
MIRT1188275	hsa-miR-1184	CLIP-seq
MIRT1188276	hsa-miR-1205	CLIP-seq
MIRT1188277	hsa-miR-125a-5p	CLIP-seq
MIRT1188278	hsa-miR-125b	CLIP-seq
MIRT1188279	hsa-miR-15a	CLIP-seq
MIRT1188280	hsa-miR-15b	CLIP-seq
MIRT1188281	hsa-miR-16	CLIP-seq
MIRT1188282	hsa-miR-1827	CLIP-seq
MIRT1188283	hsa-miR-195	CLIP-seq
MIRT1188284	hsa-miR-208a	CLIP-seq
MIRT1188285	hsa-miR-208b	CLIP-seq
MIRT1188286	hsa-miR-2467-3p	CLIP-seq
MIRT1188287	hsa-miR-31	CLIP-seq
MIRT1188288	hsa-miR-3125	CLIP-seq
MIRT1188289	hsa-miR-3128	CLIP-seq
MIRT1188290	hsa-miR-3136-3p	CLIP-seq
MIRT1188291	hsa-miR-3137	CLIP-seq
MIRT1188292	hsa-miR-3150b-3p	CLIP-seq
MIRT1188293	hsa-miR-3158-5p	CLIP-seq
MIRT1188294	hsa-miR-3160-3p	CLIP-seq
MIRT1188295	hsa-miR-3190	CLIP-seq
MIRT1188296	hsa-miR-3194-3p	CLIP-seq
MIRT1188297	hsa-miR-3617	CLIP-seq
MIRT1188298	hsa-miR-3658	CLIP-seq
MIRT1188299	hsa-miR-3916	CLIP-seq
MIRT1188300	hsa-miR-424	CLIP-seq
MIRT1188301	hsa-miR-4310	CLIP-seq
MIRT1188302	hsa-miR-4319	CLIP-seq
MIRT1188303	hsa-miR-4434	CLIP-seq
MIRT1188304	hsa-miR-4477a	CLIP-seq
MIRT1188305	hsa-miR-4481	CLIP-seq
MIRT1188306	hsa-miR-4487	CLIP-seq
MIRT1188307	hsa-miR-4493	CLIP-seq
MIRT1188308	hsa-miR-4516	CLIP-seq
MIRT1188309	hsa-miR-4641	CLIP-seq
MIRT1188310	hsa-miR-4696	CLIP-seq
MIRT1188311	hsa-miR-4745-5p	CLIP-seq
MIRT1188312	hsa-miR-4753-5p	CLIP-seq
MIRT1188313	hsa-miR-4758-5p	CLIP-seq
MIRT1188314	hsa-miR-4779	CLIP-seq
MIRT1188315	hsa-miR-4784	CLIP-seq
MIRT1188316	hsa-miR-495	CLIP-seq
MIRT1188317	hsa-miR-497	CLIP-seq
MIRT1188318	hsa-miR-499-5p	CLIP-seq
MIRT1188319	hsa-miR-544	CLIP-seq
MIRT1188320	hsa-miR-556-5p	CLIP-seq
MIRT1188321	hsa-miR-558	CLIP-seq
MIRT1188322	hsa-miR-606	CLIP-seq
MIRT1188323	hsa-miR-617	CLIP-seq
MIRT1188324	hsa-miR-641	CLIP-seq
MIRT1188325	hsa-miR-642b	CLIP-seq
MIRT1188326	hsa-miR-671-5p	CLIP-seq
MIRT1188327	hsa-miR-877	CLIP-seq
MIRT1188328	hsa-miR-940	CLIP-seq
MIRT1551787	hsa-miR-1207-3p	CLIP-seq
MIRT1188282	hsa-miR-1827	CLIP-seq
MIRT1551788	hsa-miR-3612	CLIP-seq
MIRT1551789	hsa-miR-3689a-3p	CLIP-seq
MIRT1551790	hsa-miR-3689c	CLIP-seq
MIRT1551791	hsa-miR-4728-5p	CLIP-seq
MIRT1551792	hsa-miR-650	CLIP-seq
MIRT1188328	hsa-miR-940	CLIP-seq
MIRT1188272	hsa-miR-103a	CLIP-seq
MIRT1188273	hsa-miR-107	CLIP-seq
MIRT1188274	hsa-miR-1183	CLIP-seq
MIRT1188277	hsa-miR-125a-5p	CLIP-seq
MIRT1188278	hsa-miR-125b	CLIP-seq
MIRT1188279	hsa-miR-15a	CLIP-seq
MIRT1188280	hsa-miR-15b	CLIP-seq
MIRT1188281	hsa-miR-16	CLIP-seq
MIRT1188283	hsa-miR-195	CLIP-seq
MIRT1188291	hsa-miR-3137	CLIP-seq
MIRT1188295	hsa-miR-3190	CLIP-seq
MIRT2054549	hsa-miR-3922-5p	CLIP-seq
MIRT1188300	hsa-miR-424	CLIP-seq
MIRT1188301	hsa-miR-4310	CLIP-seq
MIRT1188302	hsa-miR-4319	CLIP-seq
MIRT2054550	hsa-miR-4443	CLIP-seq
MIRT1188305	hsa-miR-4481	CLIP-seq
MIRT1188309	hsa-miR-4641	CLIP-seq
MIRT2054551	hsa-miR-4691-3p	CLIP-seq
MIRT1188311	hsa-miR-4745-5p	CLIP-seq
MIRT1188312	hsa-miR-4753-5p	CLIP-seq
MIRT1188313	hsa-miR-4758-5p	CLIP-seq
MIRT1188317	hsa-miR-497	CLIP-seq
MIRT2054552	hsa-miR-510	CLIP-seq
MIRT2054553	hsa-miR-512-5p	CLIP-seq
MIRT1188326	hsa-miR-671-5p	CLIP-seq
MIRT1188272	hsa-miR-103a	CLIP-seq
MIRT2283619	hsa-miR-106a	CLIP-seq
MIRT2283620	hsa-miR-106b	CLIP-seq
MIRT1188273	hsa-miR-107	CLIP-seq
MIRT1188274	hsa-miR-1183	CLIP-seq
MIRT2283621	hsa-miR-1236	CLIP-seq
MIRT1188277	hsa-miR-125a-5p	CLIP-seq
MIRT1188278	hsa-miR-125b	CLIP-seq
MIRT2283622	hsa-miR-128	CLIP-seq
MIRT2283623	hsa-miR-142-5p	CLIP-seq
MIRT1188279	hsa-miR-15a	CLIP-seq
MIRT1188280	hsa-miR-15b	CLIP-seq
MIRT1188281	hsa-miR-16	CLIP-seq
MIRT2283624	hsa-miR-17	CLIP-seq
MIRT1188283	hsa-miR-195	CLIP-seq
MIRT2283625	hsa-miR-200b	CLIP-seq
MIRT2283626	hsa-miR-200c	CLIP-seq
MIRT2283627	hsa-miR-20a	CLIP-seq
MIRT2283628	hsa-miR-20b	CLIP-seq
MIRT2283629	hsa-miR-27a	CLIP-seq
MIRT2283630	hsa-miR-27b	CLIP-seq
MIRT2283631	hsa-miR-302a	CLIP-seq
MIRT2283632	hsa-miR-302b	CLIP-seq
MIRT2283633	hsa-miR-302c	CLIP-seq
MIRT2283634	hsa-miR-302d	CLIP-seq
MIRT2283635	hsa-miR-302e	CLIP-seq
MIRT2283636	hsa-miR-3153	CLIP-seq
MIRT1188295	hsa-miR-3190	CLIP-seq
MIRT2283637	hsa-miR-369-3p	CLIP-seq
MIRT2283638	hsa-miR-372	CLIP-seq
MIRT2283639	hsa-miR-373	CLIP-seq
MIRT2283640	hsa-miR-374a	CLIP-seq
MIRT2283641	hsa-miR-374b	CLIP-seq
MIRT2283642	hsa-miR-412	CLIP-seq
MIRT1188300	hsa-miR-424	CLIP-seq
MIRT2283643	hsa-miR-429	CLIP-seq
MIRT1188301	hsa-miR-4310	CLIP-seq
MIRT1188302	hsa-miR-4319	CLIP-seq
MIRT1188305	hsa-miR-4481	CLIP-seq
MIRT2283644	hsa-miR-4663	CLIP-seq
MIRT2283645	hsa-miR-4668-5p	CLIP-seq
MIRT2283646	hsa-miR-4685-5p	CLIP-seq
MIRT2283647	hsa-miR-4693-5p	CLIP-seq
MIRT1188310	hsa-miR-4696	CLIP-seq
MIRT2283648	hsa-miR-4699-3p	CLIP-seq
MIRT1188311	hsa-miR-4745-5p	CLIP-seq
MIRT1188313	hsa-miR-4758-5p	CLIP-seq
MIRT2283649	hsa-miR-4802-3p	CLIP-seq
MIRT1188317	hsa-miR-497	CLIP-seq
MIRT2283650	hsa-miR-512-3p	CLIP-seq
MIRT2283651	hsa-miR-513a-5p	CLIP-seq
MIRT2283652	hsa-miR-519d	CLIP-seq
MIRT2283653	hsa-miR-520a-3p	CLIP-seq
MIRT2283654	hsa-miR-520b	CLIP-seq
MIRT2283655	hsa-miR-520c-3p	CLIP-seq
MIRT2283656	hsa-miR-520d-3p	CLIP-seq
MIRT2283657	hsa-miR-520e	CLIP-seq
MIRT2283658	hsa-miR-548u	CLIP-seq
MIRT1188322	hsa-miR-606	CLIP-seq
MIRT1188325	hsa-miR-642b	CLIP-seq
MIRT1188326	hsa-miR-671-5p	CLIP-seq
MIRT2283659	hsa-miR-759	CLIP-seq
MIRT2283660	hsa-miR-93	CLIP-seq
MIRT2455282	hsa-miR-3159	CLIP-seq
MIRT2455283	hsa-miR-4282	CLIP-seq
MIRT2455284	hsa-miR-665	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
NR1I2	Repression	14688115

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001819	Process	Positive regulation of cytokine production	IEA
GO:0002221	Process	Pattern recognition receptor signaling pathway	IDA	31649195
GO:0002376	Process	Immune system process	IEA
GO:0002606	Process	Positive regulation of dendritic cell antigen processing and presentation	IEA
GO:0002606	Process	Positive regulation of dendritic cell antigen processing and presentation	ISS
GO:0005515	Function	Protein binding	IPI	15107016, 15657077, 17054981, 17337451, 17420470, 19043560, 19337385, 20534456, 23935490, 29997244, 32814053, 37398436
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	10329646
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	15967716
GO:0005829	Component	Cytosol	IDA	31649195
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	17970764, 31649195
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	31649195
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	10329646
GO:0006952	Process	Defense response	TAS	15967716
GO:0006954	Process	Inflammatory response	TAS	15967716
GO:0007165	Process	Signal transduction	TAS	10329646, 15967716
GO:0007254	Process	JNK cascade	IEA
GO:0008656	Function	Cysteine-type endopeptidase activator activity involved in apoptotic process	TAS	10329646
GO:0009595	Process	Detection of biotic stimulus	TAS	15967716
GO:0010508	Process	Positive regulation of autophagy	IEA
GO:0016020	Component	Membrane	IEA
GO:0016045	Process	Detection of bacterium	IDA	15653568
GO:0016323	Component	Basolateral plasma membrane	IDA	19043560
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	15653568
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	15653568
GO:0038187	Function	Pattern recognition receptor activity	IDA	11058605, 12791997, 12796777, 12871942, 23300079, 31649195, 33942347
GO:0038187	Function	Pattern recognition receptor activity	IEA
GO:0042742	Process	Defense response to bacterium	IDA	11058605, 12791997, 15653568
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042802	Function	Identical protein binding	IDA	10329646
GO:0042802	Function	Identical protein binding	IPI	18186648
GO:0042803	Function	Protein homodimerization activity	IPI	18186648
GO:0042834	Function	Peptidoglycan binding	IDA	12791997, 12796777, 12871942, 16211083
GO:0042834	Function	Peptidoglycan binding	IEA
GO:0042834	Function	Peptidoglycan binding	TAS	15967716
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	10329646
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	12791997
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043130	Function	Ubiquitin binding	IDA	23300079
GO:0044877	Function	Protein-containing complex binding	IPI	17337451
GO:0045087	Process	Innate immune response	IEA
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0050700	Function	CARD domain binding	IDA	10329646
GO:0050829	Process	Defense response to Gram-negative bacterium	IDA	12791997, 12796777
GO:0050830	Process	Defense response to Gram-positive bacterium	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	17054981, 19043560
GO:0051403	Process	Stress-activated MAPK cascade	IEA
GO:0060907	Process	Positive regulation of macrophage cytokine production	IEA
GO:0070371	Process	ERK1 and ERK2 cascade	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0070427	Process	Nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA	11058605, 12791997, 12796777
GO:0070427	Process	Nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA
GO:0071225	Process	Cellular response to muramyl dipeptide	IMP	25093298
GO:0098792	Process	Xenophagy	IEA
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IMP	25093298
GO:1904417	Process	Positive regulation of xenophagy	IEA

MIM	HGNC	e!Ensembl
605980	16390	ENSG00000106100

Protein

UniProt ID

Q9Y239

Protein name

Nucleotide-binding oligomerization domain-containing protein 1 (hNod1) (Caspase recruitment domain-containing protein 4)

Protein function

Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses (PubMed:11058605, PubMed:12791997, PubMed:12796777, PubMed:15044951, Pu

PDB

2B1W , 2DBD , 2NSN , 2NZ7 , 4E9M , 4JQW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00619	CARD	20 → 104	Caspase recruitment domain	Domain
PF05729	NACHT	196 → 368	NACHT domain	Domain
PF17779	NOD2_WH	458 → 515	NOD2 winged helix domain	Domain
PF17776	NLRC4_HD2	517 → 669	NLRC4 helical domain HD2	Domain
PF13516	LRR_6	728 → 749	Leucine Rich repeat	Repeat
PF13516	LRR_6	782 → 805	Leucine Rich repeat	Repeat
PF13516	LRR_6	838 → 861	Leucine Rich repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary (PubMed:10224040). Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon (PubMed:10224040). {ECO:0000269|PubMed:10224040}.

Sequence

MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCA
CPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVV
VNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSL
ACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFS
CFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPD
SSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAY
ARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMT
LTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQ
EEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQEL
LRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK
QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIY
ETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV
RELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL
DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP
SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH
LWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF

Sequence length

953

Interactions

View interactions

	KEGG		Reactome
	NOD-like receptor signaling pathway Epithelial cell signaling in Helicobacter pylori infection Shigellosis Salmonella infection Pertussis		NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling

NOD1 (nucleotide binding oligomerization domain containing 1)