BTN3A3 (butyrophilin subfamily 3 member A3)

Gene

• Entrez ID: 10384
• Gene name: Butyrophilin subfamily 3 member A3
• Gene symbol: BTN3A3
• Synonyms (NCBI Gene): BTF3, BTN3.3
• Chromosome: 6
• Chromosome location: 6p22.2
• Summary: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of hum

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018863	hsa-miR-335-5p	Microarray	18185580
MIRT020447	hsa-miR-106b-5p	Microarray	17242205
MIRT030012	hsa-miR-26b-5p	Microarray	19088304
MIRT039804	hsa-miR-615-3p	CLASH	23622248
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT559162	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT559161	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT559160	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT559159	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT559158	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT559157	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT559156	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT559155	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT559154	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT559153	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT559152	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT559151	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT559150	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT559149	hsa-miR-646	PAR-CLIP	21572407
MIRT559147	hsa-miR-4274	PAR-CLIP	21572407
MIRT559148	hsa-miR-3163	PAR-CLIP	21572407
MIRT559146	hsa-miR-5692b	PAR-CLIP	21572407
MIRT559145	hsa-miR-5692c	PAR-CLIP	21572407
MIRT559144	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT559143	hsa-miR-302a-5p	PAR-CLIP	21572407
MIRT559142	hsa-miR-4660	PAR-CLIP	21572407
MIRT559141	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT559140	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT020447	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT441094	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT441093	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT020447	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT728175	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT728174	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT728172	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT728173	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT441094	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT441093	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT559162	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT559161	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT559160	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT559159	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT559158	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT559157	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT559156	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT559155	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT559154	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT559153	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT559152	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT559151	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT559150	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT559149	hsa-miR-646	PAR-CLIP	21572407
MIRT559147	hsa-miR-4274	PAR-CLIP	21572407
MIRT559148	hsa-miR-3163	PAR-CLIP	21572407
MIRT559146	hsa-miR-5692b	PAR-CLIP	21572407
MIRT559145	hsa-miR-5692c	PAR-CLIP	21572407
MIRT559144	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT559143	hsa-miR-302a-5p	PAR-CLIP	21572407
MIRT559142	hsa-miR-4660	PAR-CLIP	21572407
MIRT559141	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT559140	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT827465	hsa-miR-3189-5p	CLIP-seq
MIRT827466	hsa-miR-4514	CLIP-seq
MIRT827467	hsa-miR-4690-5p	CLIP-seq
MIRT827468	hsa-miR-4692	CLIP-seq
MIRT827469	hsa-miR-4758-3p	CLIP-seq
MIRT827470	hsa-miR-488	CLIP-seq
MIRT827471	hsa-miR-595	CLIP-seq
MIRT827472	hsa-miR-644	CLIP-seq
MIRT827473	hsa-miR-663b	CLIP-seq
MIRT827474	hsa-miR-3148	CLIP-seq
MIRT827475	hsa-miR-3153	CLIP-seq
MIRT827476	hsa-miR-3155	CLIP-seq
MIRT827477	hsa-miR-3155b	CLIP-seq
MIRT827478	hsa-miR-3652	CLIP-seq
MIRT827479	hsa-miR-4430	CLIP-seq
MIRT827480	hsa-miR-4648	CLIP-seq
MIRT827481	hsa-miR-4654	CLIP-seq
MIRT827482	hsa-miR-4668-5p	CLIP-seq
MIRT827483	hsa-miR-4769-5p	CLIP-seq
MIRT827484	hsa-miR-484	CLIP-seq
MIRT827485	hsa-miR-548c-3p	CLIP-seq
MIRT2183337	hsa-miR-1262	CLIP-seq
MIRT2183338	hsa-miR-1292	CLIP-seq
MIRT2183339	hsa-miR-1293	CLIP-seq
MIRT2183340	hsa-miR-3074-3p	CLIP-seq
MIRT2183341	hsa-miR-3147	CLIP-seq
MIRT2183342	hsa-miR-4425	CLIP-seq
MIRT2183343	hsa-miR-4471	CLIP-seq
MIRT2183344	hsa-miR-4483	CLIP-seq
MIRT2183345	hsa-miR-4701-3p	CLIP-seq
MIRT827466	hsa-miR-4514	CLIP-seq
MIRT827467	hsa-miR-4690-5p	CLIP-seq
MIRT827468	hsa-miR-4692	CLIP-seq
MIRT2676157	hsa-miR-1245	CLIP-seq
MIRT2676158	hsa-miR-1251	CLIP-seq
MIRT2676159	hsa-miR-1252	CLIP-seq
MIRT2676160	hsa-miR-1254	CLIP-seq
MIRT2676161	hsa-miR-137	CLIP-seq
MIRT2676162	hsa-miR-150	CLIP-seq
MIRT2676163	hsa-miR-2053	CLIP-seq
MIRT2676164	hsa-miR-21	CLIP-seq
MIRT2676165	hsa-miR-216b	CLIP-seq
MIRT2183340	hsa-miR-3074-3p	CLIP-seq
MIRT2676166	hsa-miR-3116	CLIP-seq
MIRT2676167	hsa-miR-3123	CLIP-seq
MIRT2676168	hsa-miR-3130-3p	CLIP-seq
MIRT2676169	hsa-miR-3150b-3p	CLIP-seq
MIRT2676170	hsa-miR-3194-3p	CLIP-seq
MIRT2676171	hsa-miR-337-3p	CLIP-seq
MIRT2676172	hsa-miR-339-5p	CLIP-seq
MIRT2676173	hsa-miR-3614-5p	CLIP-seq
MIRT2676174	hsa-miR-3618	CLIP-seq
MIRT2676175	hsa-miR-3675-3p	CLIP-seq
MIRT2676176	hsa-miR-3682-3p	CLIP-seq
MIRT2676177	hsa-miR-3685	CLIP-seq
MIRT2676178	hsa-miR-384	CLIP-seq
MIRT2676179	hsa-miR-3913-3p	CLIP-seq
MIRT2676180	hsa-miR-3919	CLIP-seq
MIRT2676181	hsa-miR-3929	CLIP-seq
MIRT2676182	hsa-miR-3942-5p	CLIP-seq
MIRT2676183	hsa-miR-409-3p	CLIP-seq
MIRT2676184	hsa-miR-4261	CLIP-seq
MIRT2676185	hsa-miR-4267	CLIP-seq
MIRT2676186	hsa-miR-4328	CLIP-seq
MIRT2676187	hsa-miR-4419b	CLIP-seq
MIRT2676188	hsa-miR-4446-5p	CLIP-seq
MIRT2676189	hsa-miR-4476	CLIP-seq
MIRT2676190	hsa-miR-4478	CLIP-seq
MIRT2676191	hsa-miR-4480	CLIP-seq
MIRT2676192	hsa-miR-4511	CLIP-seq
MIRT827481	hsa-miR-4654	CLIP-seq
MIRT2676193	hsa-miR-4689	CLIP-seq
MIRT827467	hsa-miR-4690-5p	CLIP-seq
MIRT2676194	hsa-miR-4693-5p	CLIP-seq
MIRT2676195	hsa-miR-4703-5p	CLIP-seq
MIRT2676196	hsa-miR-4710	CLIP-seq
MIRT2676197	hsa-miR-4713-5p	CLIP-seq
MIRT2676198	hsa-miR-4719	CLIP-seq
MIRT2676199	hsa-miR-4727-3p	CLIP-seq
MIRT2676200	hsa-miR-4755-5p	CLIP-seq
MIRT2676201	hsa-miR-4760-3p	CLIP-seq
MIRT2676202	hsa-miR-4760-5p	CLIP-seq
MIRT827483	hsa-miR-4769-5p	CLIP-seq
MIRT2676203	hsa-miR-4784	CLIP-seq
MIRT2676204	hsa-miR-4792	CLIP-seq
MIRT2676205	hsa-miR-4793-3p	CLIP-seq
MIRT2676206	hsa-miR-489	CLIP-seq
MIRT2676207	hsa-miR-502-5p	CLIP-seq
MIRT2676208	hsa-miR-516a-3p	CLIP-seq
MIRT2676209	hsa-miR-532-3p	CLIP-seq
MIRT2676210	hsa-miR-544	CLIP-seq
MIRT2676211	hsa-miR-548ac	CLIP-seq
MIRT2676212	hsa-miR-548ae	CLIP-seq
MIRT2676213	hsa-miR-548aj	CLIP-seq
MIRT2676214	hsa-miR-548am	CLIP-seq
MIRT2676215	hsa-miR-548b-3p	CLIP-seq
MIRT2676216	hsa-miR-548d-3p	CLIP-seq
MIRT2676217	hsa-miR-548x	CLIP-seq
MIRT2676218	hsa-miR-548z	CLIP-seq
MIRT2676219	hsa-miR-549	CLIP-seq
MIRT2676220	hsa-miR-561	CLIP-seq
MIRT2676221	hsa-miR-569	CLIP-seq
MIRT2676222	hsa-miR-590-5p	CLIP-seq
MIRT2676223	hsa-miR-633	CLIP-seq
MIRT2676224	hsa-miR-640	CLIP-seq
MIRT2676225	hsa-miR-661	CLIP-seq
MIRT2676226	hsa-miR-875-3p	CLIP-seq
MIRT2676227	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002456	Process	T cell mediated immunity	IMP	22767497
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	29339503, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA	22767497
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0050852	Process	T cell receptor signaling pathway	IBA

Other IDs

• MIM: 613595
• HGNC: 1140
• e!Ensembl: ENSG00000111801

Protein

• UniProt ID: O00478
• Protein name: Butyrophilin subfamily 3 member A3
• Protein function: Plays a role in T-cell responses in the adaptive immune response.
• PDB: 4F8T, 5ZZ3, 6J0G, 6J0K, 6J0L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	35 → 144	Immunoglobulin V-set domain	Domain
  PF13765	PRY	342 → 390	SPRY-associated domain	Family
  PF00622	SPRY	394 → 506	SPRY domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected in spleen and lymphocytes. {ECO:0000269|PubMed:20610803}.
• Sequence:

  MKMASSLAFLLLNFHVSLFLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSA
  ETMELRWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASD
  SGKYLCYFQDGDFYEKALVELKVAALGSDLHIEVKGYEDGGIHLECRSTGWYPQPQIKWS
  DTKGENIPAVEAPVVADGVGLYAVAASVIMRGSSGGGVSCIIRNSLLGLEKTASISIADP
  FFRSAQPWIAALAGTLPISLLLLAGASYFLWRQQKEKIALSRETEREREMKEMGYAATEQ
  EISLREKLQEELKWRKIQYMARGEKSLAYHEWKMALFKPADVILDPDTANAILLVSEDQR
  SVQRAEEPRDLPDNPERFEWRYCVLGCENFTSGRHYWEVEVGDRKEWHIGVCSKNVERKK
  GWVKMTPENGYWTMGLTDGNKYRALTEPRTNLKLPEPPRKVGIFLDYETGEISFYNATDG
  SHIYTFPHASFSEPLYPVFRILTLEPTALTICPIPKEVESSPDPDLVPDHSLETPLTPGL
  ANESGEPQAEVTSLLLPAHPGAEVSPSATTNQNHKLQARTEALY

• Sequence length: 584

Pathways

Reactome:

Butyrophilin (BTN) family interactions