AKR1A1 (aldo-keto reductase family 1 member A1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10327
Gene name Gene Name - the full gene name approved by the HGNC.
Aldo-keto reductase family 1 member A1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AKR1A1
Synonyms (NCBI Gene) Gene synonyms aliases
ALDR1, ALR, ARM, DD3, HEL-S-6
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present i
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT025351 hsa-miR-34a-5p Proteomics 21566225
MIRT032282 hsa-let-7b-5p Proteomics 18668040
MIRT045288 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(42)
GO ID Ontology Definition Evidence Reference
GO:0004032 Function Aldose reductase (NADPH) activity IBA
GO:0004032 Function Aldose reductase (NADPH) activity IEA
GO:0004032 Function Aldose reductase (NADPH) activity TAS 2498333
GO:0004745 Function All-trans-retinol dehydrogenase (NAD+) activity ISS
GO:0005515 Function Protein binding IPI 21044950, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
103830 380 ENSG00000117448
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P14550
Protein name Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20) (S-nitroso-CoA reductase) (ScorR) (EC
Protein function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128). Displays enzymatic activity towards endogenous metabolites such as aromatic and alipha
PDB 2ALR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00248 Aldo_ket_red 16 → 294 Aldo/keto reductase family Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung. {ECO:0000269|PubMed:10486210, ECO:0000269|PubMed:10510318,
Sequence
Sequence length 325
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glycolysis / Gluconeogenesis
Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Glycerolipid metabolism
Pyruvate metabolism
Metabolic pathways
Biosynthesis of cofactors
Chemical carcinogenesis - reactive oxygen species 		  Glutathione conjugation
Formation of xylulose-5-phosphate
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer N/A N/A GWAS
Colorectal Cancer Early onset colorectal cancer N/A N/A GWAS
Show/Hide Text Mining Associations (34)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30727821
Alcoholism Associate 16425414, 23468174, 31933193
Alzheimer Disease Associate 10600649
Autistic Disorder Associate 23468174
Breast Neoplasms Associate 17295732
Carcinogenesis Associate 21517275
Carcinoma Hepatocellular Associate 2167445, 29600553, 30653870
Carcinoma Non Small Cell Lung Associate 29808834
Cardiotoxicity Associate 24562808
Colorectal Neoplasms Associate 17517051