CRISP3 (cysteine rich secretory protein 3)

Gene

• Entrez ID: 10321
• Gene name: Cysteine rich secretory protein 3
• Gene symbol: CRISP3
• Synonyms (NCBI Gene): Aeg2, CRISP-3, CRS3, SGP28, dJ442L6.3
• Disease Acronyms (UniProt): CRS3
• Chromosome: 6
• Chromosome location: 6p12.3
• Summary: This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT036271	hsa-miR-1229-3p	CLASH	23622248
MIRT909781	hsa-miR-129-3p	CLIP-seq
MIRT909782	hsa-miR-151-3p	CLIP-seq
MIRT909783	hsa-miR-3123	CLIP-seq
MIRT909784	hsa-miR-3130-5p	CLIP-seq
MIRT909785	hsa-miR-3160-5p	CLIP-seq
MIRT909786	hsa-miR-33a	CLIP-seq
MIRT909787	hsa-miR-33b	CLIP-seq
MIRT909788	hsa-miR-3647-3p	CLIP-seq
MIRT909789	hsa-miR-3651	CLIP-seq
MIRT909790	hsa-miR-384	CLIP-seq
MIRT909791	hsa-miR-3919	CLIP-seq
MIRT909792	hsa-miR-4282	CLIP-seq
MIRT909793	hsa-miR-4328	CLIP-seq
MIRT909794	hsa-miR-4481	CLIP-seq
MIRT909795	hsa-miR-4482	CLIP-seq
MIRT909796	hsa-miR-4494	CLIP-seq
MIRT909797	hsa-miR-450b-5p	CLIP-seq
MIRT909798	hsa-miR-4658	CLIP-seq
MIRT909799	hsa-miR-4662a-3p	CLIP-seq
MIRT909800	hsa-miR-4687-5p	CLIP-seq
MIRT909801	hsa-miR-4699-3p	CLIP-seq
MIRT909802	hsa-miR-4745-5p	CLIP-seq
MIRT909803	hsa-miR-4758-5p	CLIP-seq
MIRT909804	hsa-miR-4797-5p	CLIP-seq
MIRT909805	hsa-miR-499a-5p	CLIP-seq
MIRT909806	hsa-miR-507	CLIP-seq
MIRT909807	hsa-miR-557	CLIP-seq
MIRT909808	hsa-miR-656	CLIP-seq
MIRT909809	hsa-miR-105	CLIP-seq
MIRT909781	hsa-miR-129-3p	CLIP-seq
MIRT909810	hsa-miR-203	CLIP-seq
MIRT909783	hsa-miR-3123	CLIP-seq
MIRT909784	hsa-miR-3130-5p	CLIP-seq
MIRT909789	hsa-miR-3651	CLIP-seq
MIRT909790	hsa-miR-384	CLIP-seq
MIRT909791	hsa-miR-3919	CLIP-seq
MIRT909793	hsa-miR-4328	CLIP-seq
MIRT909795	hsa-miR-4482	CLIP-seq
MIRT909811	hsa-miR-4684-5p	CLIP-seq
MIRT909800	hsa-miR-4687-5p	CLIP-seq
MIRT909812	hsa-miR-4768-5p	CLIP-seq
MIRT909804	hsa-miR-4797-5p	CLIP-seq
MIRT2205766	hsa-miR-331-3p	CLIP-seq
MIRT2205767	hsa-miR-3607-3p	CLIP-seq
MIRT2205768	hsa-miR-4713-5p	CLIP-seq
MIRT2205769	hsa-miR-4775	CLIP-seq
MIRT2205770	hsa-miR-590-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Unknown	11223178
ERG	Unknown	21814574

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005576	Component	Extracellular region	IDA	8601434, 12009203, 12223513, 12433721
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006952	Process	Defense response	NAS	12647793
GO:0031012	Component	Extracellular matrix	NAS	12223513
GO:0035580	Component	Specific granule lumen	TAS
GO:0042581	Component	Specific granule	IDA	8601434, 12223513
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045087	Process	Innate immune response	NAS	12223513
GO:1904724	Component	Tertiary granule lumen	TAS

Other IDs

• MIM: 618062
• HGNC: 16904
• e!Ensembl: ENSG00000096006

Protein

• UniProt ID: P54108
• Protein name: Cysteine-rich secretory protein 3 (CRISP-3) (Specific granule protein of 28 kDa) (SGP28)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00188	CAP	43 → 171	Cysteine-rich secretory protein family	Domain
  PF08562	Crisp	191 → 245	Crisp	Domain

• Tissue specificity: TISSUE SPECIFICITY: Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.
• Sequence:

  MTLFPVLLFLVAGLLPSFPANEDKDPAFTALLTTQTQVQREIVNKHNELRRAVSPPARNM
  LKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASSSWSQAIQSWFDEY
  NDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANR
  LYVPYEQGAPCASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNC
  SNSIY

• Sequence length: 245

Pathways

Reactome:

Neutrophil degranulation