Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10277
Gene name	Ubiquitination factor E4B
Gene symbol	UBE4B
Synonyms (NCBI Gene)	E4HDNB1UBOX3UFD2UFD2A
Chromosome	1
Chromosome location	1p36.22
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016837	hsa-miR-335-5p	Microarray	18185580
MIRT049579	hsa-miR-92a-3p	CLASH	23622248
MIRT042528	hsa-miR-423-3p	CLASH	23622248
MIRT621670	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT621669	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT621668	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT621667	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT621666	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT621663	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT621662	hsa-miR-3671	HITS-CLIP	23824327
MIRT621660	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT621659	hsa-miR-607	HITS-CLIP	23824327
MIRT621658	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT621670	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT621669	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT621668	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT621667	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT621663	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT621662	hsa-miR-3671	HITS-CLIP	23824327
MIRT621660	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT621659	hsa-miR-607	HITS-CLIP	23824327
MIRT621671	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT621670	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT621669	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT621668	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT621667	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT621666	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT621665	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT621664	hsa-miR-6798-3p	HITS-CLIP	23824327
MIRT621663	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT621662	hsa-miR-3671	HITS-CLIP	23824327
MIRT621661	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT621660	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT621659	hsa-miR-607	HITS-CLIP	23824327
MIRT621658	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT464623	hsa-miR-4476	PAR-CLIP	23592263
MIRT464621	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT464620	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT464619	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT464618	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT464617	hsa-miR-1178-5p	PAR-CLIP	23592263
MIRT464616	hsa-miR-1182	PAR-CLIP	23592263
MIRT464615	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT464614	hsa-miR-3179	PAR-CLIP	23592263
MIRT464613	hsa-miR-3148	PAR-CLIP	23592263
MIRT464612	hsa-miR-3202	PAR-CLIP	23592263
MIRT464611	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT464610	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT464609	hsa-miR-8085	PAR-CLIP	23592263
MIRT464608	hsa-miR-3175	PAR-CLIP	23592263
MIRT464607	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT464605	hsa-miR-5698	PAR-CLIP	23592263
MIRT464606	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT464604	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT442709	hsa-miR-9-5p	PAR-CLIP	22100165
MIRT442708	hsa-miR-4753-5p	PAR-CLIP	22100165
MIRT442707	hsa-miR-1251-3p	PAR-CLIP	22100165
MIRT442706	hsa-miR-3926	PAR-CLIP	22100165
MIRT442705	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT621670	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT621669	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT621668	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT621667	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT621666	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT621663	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT621662	hsa-miR-3671	HITS-CLIP	23824327
MIRT621660	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT621659	hsa-miR-607	HITS-CLIP	23824327
MIRT621658	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT621670	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT621669	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT621668	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT621667	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT621663	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT621662	hsa-miR-3671	HITS-CLIP	23824327
MIRT621660	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT621659	hsa-miR-607	HITS-CLIP	23824327
MIRT621671	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT621670	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT621669	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT621668	hsa-miR-218-2-3p	HITS-CLIP	23824327
MIRT621667	hsa-miR-758-5p	HITS-CLIP	23824327
MIRT621666	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT621665	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT621664	hsa-miR-6798-3p	HITS-CLIP	23824327
MIRT621663	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT621662	hsa-miR-3671	HITS-CLIP	23824327
MIRT621661	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT621660	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT621659	hsa-miR-607	HITS-CLIP	23824327
MIRT621658	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT464623	hsa-miR-4476	PAR-CLIP	23592263
MIRT464621	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT464620	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT464619	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT464618	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT464617	hsa-miR-1178-5p	PAR-CLIP	23592263
MIRT464616	hsa-miR-1182	PAR-CLIP	23592263
MIRT464615	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT464614	hsa-miR-3179	PAR-CLIP	23592263
MIRT464613	hsa-miR-3148	PAR-CLIP	23592263
MIRT464612	hsa-miR-3202	PAR-CLIP	23592263
MIRT464611	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT464610	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT464609	hsa-miR-8085	PAR-CLIP	23592263
MIRT464608	hsa-miR-3175	PAR-CLIP	23592263
MIRT464607	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT464605	hsa-miR-5698	PAR-CLIP	23592263
MIRT464606	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT464604	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT442709	hsa-miR-9-5p	PAR-CLIP	22100165
MIRT442708	hsa-miR-4753-5p	PAR-CLIP	22100165
MIRT442707	hsa-miR-1251-3p	PAR-CLIP	22100165
MIRT442706	hsa-miR-3926	PAR-CLIP	22100165
MIRT442705	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT1469607	hsa-miR-1184	CLIP-seq
MIRT1469608	hsa-miR-1245b-3p	CLIP-seq
MIRT1469609	hsa-miR-129-5p	CLIP-seq
MIRT1469610	hsa-miR-1301	CLIP-seq
MIRT1469611	hsa-miR-130a	CLIP-seq
MIRT1469612	hsa-miR-130b	CLIP-seq
MIRT1469613	hsa-miR-141	CLIP-seq
MIRT1469614	hsa-miR-148a	CLIP-seq
MIRT1469615	hsa-miR-148b	CLIP-seq
MIRT1469616	hsa-miR-152	CLIP-seq
MIRT1469617	hsa-miR-15a	CLIP-seq
MIRT1469618	hsa-miR-15b	CLIP-seq
MIRT1469619	hsa-miR-16	CLIP-seq
MIRT1469620	hsa-miR-1915	CLIP-seq
MIRT1469621	hsa-miR-195	CLIP-seq
MIRT1469622	hsa-miR-200a	CLIP-seq
MIRT1469623	hsa-miR-2117	CLIP-seq
MIRT1469624	hsa-miR-301a	CLIP-seq
MIRT1469625	hsa-miR-301b	CLIP-seq
MIRT1469626	hsa-miR-3153	CLIP-seq
MIRT1469627	hsa-miR-3159	CLIP-seq
MIRT1469628	hsa-miR-3163	CLIP-seq
MIRT1469629	hsa-miR-342-3p	CLIP-seq
MIRT1469630	hsa-miR-34b	CLIP-seq
MIRT1469631	hsa-miR-3614-5p	CLIP-seq
MIRT1469632	hsa-miR-3666	CLIP-seq
MIRT1469633	hsa-miR-3977	CLIP-seq
MIRT1469634	hsa-miR-424	CLIP-seq
MIRT1469635	hsa-miR-4268	CLIP-seq
MIRT1469636	hsa-miR-4269	CLIP-seq
MIRT1469637	hsa-miR-4295	CLIP-seq
MIRT1469638	hsa-miR-4307	CLIP-seq
MIRT1469639	hsa-miR-4330	CLIP-seq
MIRT1469640	hsa-miR-4443	CLIP-seq
MIRT1469641	hsa-miR-4448	CLIP-seq
MIRT1469642	hsa-miR-4519	CLIP-seq
MIRT1469643	hsa-miR-4524	CLIP-seq
MIRT1469644	hsa-miR-454	CLIP-seq
MIRT1469645	hsa-miR-4640-5p	CLIP-seq
MIRT1469646	hsa-miR-4660	CLIP-seq
MIRT1469647	hsa-miR-4668-3p	CLIP-seq
MIRT1469648	hsa-miR-4684-5p	CLIP-seq
MIRT1469649	hsa-miR-4690-5p	CLIP-seq
MIRT1469650	hsa-miR-4698	CLIP-seq
MIRT1469651	hsa-miR-4726-3p	CLIP-seq
MIRT1469652	hsa-miR-4726-5p	CLIP-seq
MIRT1469653	hsa-miR-4753-3p	CLIP-seq
MIRT1469654	hsa-miR-497	CLIP-seq
MIRT1469655	hsa-miR-500a	CLIP-seq
MIRT1469656	hsa-miR-503	CLIP-seq
MIRT1469657	hsa-miR-5047	CLIP-seq
MIRT1469658	hsa-miR-545	CLIP-seq
MIRT1469659	hsa-miR-548c-3p	CLIP-seq
MIRT1469660	hsa-miR-548p	CLIP-seq
MIRT1469661	hsa-miR-646	CLIP-seq
MIRT1469662	hsa-miR-873	CLIP-seq
MIRT1469663	hsa-miR-942	CLIP-seq
MIRT2141237	hsa-miR-1185	CLIP-seq
MIRT1469617	hsa-miR-15a	CLIP-seq
MIRT1469618	hsa-miR-15b	CLIP-seq
MIRT1469619	hsa-miR-16	CLIP-seq
MIRT1469621	hsa-miR-195	CLIP-seq
MIRT1469626	hsa-miR-3153	CLIP-seq
MIRT1469629	hsa-miR-342-3p	CLIP-seq
MIRT2141238	hsa-miR-3611	CLIP-seq
MIRT2141239	hsa-miR-361-3p	CLIP-seq
MIRT2141240	hsa-miR-3679-5p	CLIP-seq
MIRT1469634	hsa-miR-424	CLIP-seq
MIRT1469635	hsa-miR-4268	CLIP-seq
MIRT1469638	hsa-miR-4307	CLIP-seq
MIRT1469640	hsa-miR-4443	CLIP-seq
MIRT1469643	hsa-miR-4524	CLIP-seq
MIRT2141241	hsa-miR-4640-3p	CLIP-seq
MIRT1469645	hsa-miR-4640-5p	CLIP-seq
MIRT1469650	hsa-miR-4698	CLIP-seq
MIRT2141242	hsa-miR-4700-3p	CLIP-seq
MIRT1469652	hsa-miR-4726-5p	CLIP-seq
MIRT2141243	hsa-miR-493	CLIP-seq
MIRT1469654	hsa-miR-497	CLIP-seq
MIRT1469656	hsa-miR-503	CLIP-seq
MIRT1469658	hsa-miR-545	CLIP-seq
MIRT2141244	hsa-miR-548g	CLIP-seq
MIRT1469660	hsa-miR-548p	CLIP-seq
MIRT1469661	hsa-miR-646	CLIP-seq
MIRT2141245	hsa-miR-668	CLIP-seq
MIRT1469663	hsa-miR-942	CLIP-seq
MIRT2362172	hsa-miR-1231	CLIP-seq
MIRT2362173	hsa-miR-4288	CLIP-seq
MIRT2362174	hsa-miR-632	CLIP-seq
MIRT1469607	hsa-miR-1184	CLIP-seq
MIRT2141237	hsa-miR-1185	CLIP-seq
MIRT1469608	hsa-miR-1245b-3p	CLIP-seq
MIRT2655987	hsa-miR-1290	CLIP-seq
MIRT1469609	hsa-miR-129-5p	CLIP-seq
MIRT1469610	hsa-miR-1301	CLIP-seq
MIRT1469613	hsa-miR-141	CLIP-seq
MIRT1469617	hsa-miR-15a	CLIP-seq
MIRT1469618	hsa-miR-15b	CLIP-seq
MIRT1469619	hsa-miR-16	CLIP-seq
MIRT1469621	hsa-miR-195	CLIP-seq
MIRT1469622	hsa-miR-200a	CLIP-seq
MIRT2655988	hsa-miR-214	CLIP-seq
MIRT2655989	hsa-miR-2278	CLIP-seq
MIRT1469626	hsa-miR-3153	CLIP-seq
MIRT2655990	hsa-miR-3188	CLIP-seq
MIRT1469629	hsa-miR-342-3p	CLIP-seq
MIRT2141238	hsa-miR-3611	CLIP-seq
MIRT1469631	hsa-miR-3614-5p	CLIP-seq
MIRT2655991	hsa-miR-3619-5p	CLIP-seq
MIRT2141240	hsa-miR-3679-5p	CLIP-seq
MIRT1469634	hsa-miR-424	CLIP-seq
MIRT1469635	hsa-miR-4268	CLIP-seq
MIRT1469636	hsa-miR-4269	CLIP-seq
MIRT1469638	hsa-miR-4307	CLIP-seq
MIRT1469639	hsa-miR-4330	CLIP-seq
MIRT1469640	hsa-miR-4443	CLIP-seq
MIRT1469641	hsa-miR-4448	CLIP-seq
MIRT2655992	hsa-miR-4457	CLIP-seq
MIRT1469645	hsa-miR-4640-5p	CLIP-seq
MIRT1469646	hsa-miR-4660	CLIP-seq
MIRT2655993	hsa-miR-4671-5p	CLIP-seq
MIRT1469649	hsa-miR-4690-5p	CLIP-seq
MIRT1469652	hsa-miR-4726-5p	CLIP-seq
MIRT2141243	hsa-miR-493	CLIP-seq
MIRT1469654	hsa-miR-497	CLIP-seq
MIRT1469657	hsa-miR-5047	CLIP-seq
MIRT2655994	hsa-miR-513b	CLIP-seq
MIRT2655995	hsa-miR-761	CLIP-seq
MIRT1469607	hsa-miR-1184	CLIP-seq
MIRT1469608	hsa-miR-1245b-3p	CLIP-seq
MIRT1469610	hsa-miR-1301	CLIP-seq
MIRT1469613	hsa-miR-141	CLIP-seq
MIRT1469622	hsa-miR-200a	CLIP-seq
MIRT1469626	hsa-miR-3153	CLIP-seq
MIRT1469629	hsa-miR-342-3p	CLIP-seq
MIRT1469631	hsa-miR-3614-5p	CLIP-seq
MIRT1469635	hsa-miR-4268	CLIP-seq
MIRT1469636	hsa-miR-4269	CLIP-seq
MIRT1469638	hsa-miR-4307	CLIP-seq
MIRT1469639	hsa-miR-4330	CLIP-seq
MIRT1469640	hsa-miR-4443	CLIP-seq
MIRT1469641	hsa-miR-4448	CLIP-seq
MIRT1469645	hsa-miR-4640-5p	CLIP-seq
MIRT1469646	hsa-miR-4660	CLIP-seq
MIRT1469649	hsa-miR-4690-5p	CLIP-seq
MIRT1469652	hsa-miR-4726-5p	CLIP-seq
MIRT1469657	hsa-miR-5047	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IEA
GO:0000151	Component	Ubiquitin ligase complex	TAS	11802788
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0003222	Process	Ventricular trabecula myocardium morphogenesis	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	20696396, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	11802788
GO:0006513	Process	Protein monoubiquitination	IEA
GO:0008626	Process	Granzyme-mediated apoptotic signaling pathway	IDA	11802788
GO:0009411	Process	Response to UV	IDA	11802788
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0019899	Function	Enzyme binding	ISS
GO:0030163	Process	Protein catabolic process	IEA
GO:0031175	Process	Neuron projection development	IEA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IBA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0036503	Process	ERAD pathway	IBA
GO:0036503	Process	ERAD pathway	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	23509263
GO:0051865	Process	Protein autoubiquitination	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
613565	12500	ENSG00000130939

O95155

Protein name

Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)

Protein function

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by anot

PDB

2KRE , 3L1X , 3L1Z , 5O75

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10408	Ufd2P_core	591 → 1212	Ubiquitin elongating factor core	Family
PF04564	U-box	1228 → 1299	U-box domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:118

Sequence

MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNM
TPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQV
DVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFL
SSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPD
RNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAA
SQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSP
QAVPASSSRQRPSSTGPPLPPASPSATSRRPSSLRISPSLGASGGASNWDSYSDHFTIET
CKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPR
SLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDY
FKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVF
AEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSY
MAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITL
PNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRL
RAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFL
RRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSP
QALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHP
LSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSG
KQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDE
RVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVEN
PEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIA
IEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILR
HLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH

Sequence length

1302

Interactions

View interactions

	KEGG
	Ubiquitin mediated proteolysis Protein processing in endoplasmic reticulum

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs189262553	RCV005932835
Developmental disorder	Uncertain significance	rs2523119409	RCV003128032
Gastric cancer	Benign	rs78519671	RCV005903395
Lung cancer	Benign	rs78519671	RCV005903397
Malignant tumor of esophagus	Likely benign	rs189262553	RCV005932836
Ovarian serous cystadenocarcinoma	Likely benign	rs189262553	RCV005932838
Sarcoma	Likely benign	rs189262553	RCV005932837
Thymoma	Benign	rs78519671	RCV005903396
Uterine corpus endometrial carcinoma	Benign	rs78519671	RCV005903398
Uveal melanoma	Benign	rs78519671	RCV005903394

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	36470669
Cardiomyopathies	Associate	24454898
Charcot Marie Tooth Disease	Associate	37595558
HAIR AN syndrome	Associate	26673821
Leukemia Lymphoma Adult T Cell	Associate	33362245
Myeloproliferative Disorder Chronic with Eosinophilia	Associate	35996826
Neoplasm Metastasis	Associate	37954063
Neoplasms	Inhibit	15740626
Neoplasms	Associate	36470669, 37954063
Neuroblastoma	Associate	22990745, 31475882, 37957138
Peripheral Nervous System Diseases	Associate	37595558

UBE4B (ubiquitination factor E4B)