Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
10221
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Tribbles pseudokinase 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
TRIB1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1 |
Chromosome
Chromosome number
|
8 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
8q24.13 |
UniProt ID |
Q96RU8
|
Protein name |
Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) |
Protein function |
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 s |
PDB |
5CEK
,
5CEM
,
5IGO
,
5IGQ
,
6DC0
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069
|
Pkinase |
105 → 338 |
Protein kinase domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. {ECO:0000269|PubMed:15299019}. |
Sequence |
|
Sequence length |
372 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Coronary artery disease |
Coronary Artery Disease |
rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 |
24097064 |
Lung carcinoma |
Large cell carcinoma of lung |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 View all (44 more) |
|
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Myocardial Infarction |
Myocardial Infarction |
|
|
GWAS |
Diabetes |
Diabetes |
|
|
GWAS |
Gout |
Gout |
|
|
GWAS |
Hyperlipidemia |
Hyperlipidemia |
|
|
GWAS |
Metabolic Syndrome |
Metabolic Syndrome |
|
|
GWAS |
Psoriasis |
Psoriasis |
|
|
GWAS |
Alzheimer disease |
Alzheimer disease |
|
|
GWAS |
Glioblastoma |
Glioblastoma |
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 |
|
GWAS, CBGDA |
Oligodendroglioma |
Oligodendroglioma |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Aortic Valve Stenosis |
Associate
|
37175670 |
Ascites |
Associate
|
17971902 |
Atherosclerosis |
Associate
|
24161842 |
Breast Neoplasms |
Associate
|
28087598 |
Carcinogenesis |
Associate
|
20691260 |
Carcinoma Hepatocellular |
Associate
|
16434963 |
Carcinoma Renal Cell |
Inhibit
|
20691260 |
Cardiovascular Diseases |
Associate
|
18987386, 26235576, 28717196 |
Cerebral Infarction |
Associate
|
30787327, 31250580 |
Cholesterol pneumonia |
Associate
|
30369316 |
Colorectal Neoplasms |
Associate
|
26678268, 28624785 |
Coronary Artery Disease |
Associate
|
21966275, 24161842, 25811180, 29502537, 30369316 |
Coronary Disease |
Associate
|
18987386, 25986010, 30787327, 31470861, 32370221 |
Fatty Liver |
Associate
|
28717196 |
Fatty Liver Alcoholic |
Associate
|
26845607 |
Gastritis |
Associate
|
37249580 |
Glioma |
Associate
|
26521947 |
Glycogen Storage Disease Type II |
Associate
|
25205864 |
Hyperlipoproteinemia Type V |
Associate
|
19656773 |
Hypothyroidism |
Associate
|
20691260 |
Kidney Diseases |
Associate
|
25540021 |
Leukemia |
Associate
|
26235576 |
Leukemia Lymphocytic Chronic B Cell |
Associate
|
30616686 |
Leukemia Myelogenous Chronic BCR ABL Positive |
Associate
|
23642027 |
Leukemia Myeloid Acute |
Associate
|
34714913, 37532789 |
Lung Neoplasms |
Associate
|
28662101 |
Macular Degeneration |
Associate
|
31191752 |
Medulloblastoma |
Associate
|
16618975 |
Metabolic Diseases |
Associate
|
26235576 |
Metabolic Syndrome |
Associate
|
24785259 |
Mitochondrial Diseases |
Associate
|
24161842 |
Myocardial Infarction |
Inhibit
|
25811180 |
Myotonic Dystrophy |
Associate
|
24027017 |
Neoplasm Metastasis |
Associate
|
28624785 |
Neoplasms |
Inhibit
|
20691260, 27171412 |
Neoplasms |
Associate
|
28087598, 28662101, 30616686 |
Neuroblastoma |
Associate
|
15778291 |
Non alcoholic Fatty Liver Disease |
Associate
|
24785259, 30851741, 31470861, 32841307, 33275980, 34558842, 35654975 |
Osteoarthritis |
Associate
|
24825461 |
Ovarian Diseases |
Associate
|
17971902 |
Ovarian Neoplasms |
Associate
|
17971902, 35269838 |
Pituitary Neoplasms |
Associate
|
32871778 |
Prostatic Neoplasms |
Associate
|
27078000 |
Prostatitis |
Associate
|
29203868 |
Triple Negative Breast Neoplasms |
Associate
|
27472710 |
|