Gene Gene information from NCBI Gene database.
Entrez ID 10221
Gene name Tribbles pseudokinase 1
Gene symbol TRIB1
Synonyms (NCBI Gene)
C8FWGIG-2GIG2SKIP1TRB-1TRB1
Chromosome 8
Chromosome location 8q24.13
miRNA miRNA information provided by mirtarbase database.
848
miRTarBase ID miRNA Experiments Reference
MIRT003109 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
MIRT003109 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
MIRT016950 hsa-miR-335-5p Microarray 18185580
MIRT027398 hsa-miR-99a-5p Sequencing 20371350
MIRT027499 hsa-miR-98-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS 17724128
GO:0004672 Function Protein kinase activity TAS 20410507
GO:0004860 Function Protein kinase inhibitor activity IEA
GO:0004860 Function Protein kinase inhibitor activity IMP 15299019
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609461 16891 ENSG00000173334
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96RU8
Protein name Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
Protein function Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 s
PDB 5CEK , 5CEM , 5IGO , 5IGQ , 6DC0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 105 338 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. {ECO:0000269|PubMed:15299019}.
Sequence
Sequence length 372
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    NGF-stimulated transcription