Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10221
Gene name Gene Name - the full gene name approved by the HGNC.
Tribbles pseudokinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRIB1
Synonyms (NCBI Gene) Gene synonyms aliases
C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.13
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003109 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003109 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT016950 hsa-miR-335-5p Microarray 18185580
MIRT027398 hsa-miR-99a-5p Sequencing 20371350
MIRT027499 hsa-miR-98-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004672 Function Protein kinase activity TAS 20410507
GO:0004860 Function Protein kinase inhibitor activity IMP 15299019
GO:0005515 Function Protein binding IPI 25852190, 28514442
GO:0005524 Function ATP binding TAS 20410507
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609461 16891 ENSG00000173334
Protein
UniProt ID Q96RU8
Protein name Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
Protein function Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 s
PDB 5CEK , 5CEM , 5IGO , 5IGQ , 6DC0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 105 338 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. {ECO:0000269|PubMed:15299019}.
Sequence
Sequence length 372
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    NGF-stimulated transcription
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 24097064
Lung carcinoma Large cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
Unknown
Disease term Disease name Evidence References Source
Myocardial Infarction Myocardial Infarction GWAS
Diabetes Diabetes GWAS
Gout Gout GWAS
Hyperlipidemia Hyperlipidemia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Aortic Valve Stenosis Associate 37175670
Ascites Associate 17971902
Atherosclerosis Associate 24161842
Breast Neoplasms Associate 28087598
Carcinogenesis Associate 20691260
Carcinoma Hepatocellular Associate 16434963
Carcinoma Renal Cell Inhibit 20691260
Cardiovascular Diseases Associate 18987386, 26235576, 28717196
Cerebral Infarction Associate 30787327, 31250580
Cholesterol pneumonia Associate 30369316