Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1021
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin dependent kinase 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDK6
Synonyms (NCBI Gene) Gene synonyms aliases
MCPH12, PLSTIRE
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MCPH12
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity o
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs606231255 C>T Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001233 hsa-miR-107 Western blot 19407485
MIRT001233 hsa-miR-107 Western blot 19407485
MIRT001233 hsa-miR-107 Western blot 19407485
MIRT002642 hsa-miR-124-3p Luciferase reporter assay, Western blot 18607543
MIRT002642 hsa-miR-124-3p Luciferase reporter assay, Western blot 18607543
Transcription factors
Transcription factor Regulation Reference
AR Unknown 15790678
MYC Activation 22395148
NANOG Repression 17761754
NANOG Unknown 19139263
NFKB2 Activation 18504428
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle TAS 16294322
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IDA 17420273
GO:0001726 Component Ruffle IDA 10205165
GO:0001954 Process Positive regulation of cell-matrix adhesion IDA 10205165
GO:0003323 Process Type B pancreatic cell development IDA 20668294
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603368 1777 ENSG00000105810
Protein
UniProt ID Q00534
Protein name Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Protein function Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and contr
PDB 1BI7 , 1BI8 , 1BLX , 1G3N , 1JOW , 1XO2 , 2EUF , 2F2C , 3NUP , 3NUX , 4AUA , 4EZ5 , 4TTH , 5L2I , 5L2S , 5L2T , 6OQL , 6OQO , 8I0M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 13 300 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. {ECO:0000269|Pub
Sequence
Sequence length 326
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
Cellular senescence
Cushing syndrome
Hepatitis C
Measles
Human cytomegalovirus infection
Influenza A
Human papillomavirus infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
MicroRNAs in cancer
Pancreatic cancer
Glioma
Melanoma
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
  Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Regulation of RUNX1 Expression and Activity
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Agenesis of corpus callosum Agenesis of corpus callosum rs754914260, rs1057519053, rs1057519056, rs1057519054, rs1057519055, rs1057519057, rs1384496494, rs1599017933
Anemia Anemia rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)
28255017
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)
29892015, 30061737
Carcinoma of the head and neck Squamous cell carcinoma of the head and neck rs121909237, rs121909250, rs121909251, rs121909252, rs28934571, rs28934574, rs28934576, rs28934578, rs121912664, rs397516436, rs121912666, rs397514495, rs587782705, rs193920774, rs730882001
View all (7 more)
29464035
Unknown
Disease term Disease name Evidence References Source
Ischemic stroke Ischemic stroke 29531354 ClinVar
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation 30061737, 29892015 ClinVar
Atrial Fibrillation Atrial Fibrillation GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 21593195, 22450065, 30718927, 34152098, 35167417
Adenocarcinoma of Lung Associate 23792647, 32091408, 36040373, 37061713
Adenomatous Polyposis Coli Associate 34370741
Adrenocortical Carcinoma Associate 29283884, 30413320, 35462410
Appendiceal Neoplasms Associate 31784493
Arthritis Rheumatoid Associate 19644859, 21676922, 25138370, 34910834
Ascites Associate 35062876
Aspartylglucosaminuria Associate 31854063
Astrocytoma Associate 37667984
Ataxia Telangiectasia Associate 9422538