TOB1 (transducer of ERBB2, 1)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10140 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Transducer of ERBB2, 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TOB1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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APRO5, APRO6, PIG49, TOB, TROB, TROB1 |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q21.33 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | P50616 | ||||||||||
| Protein name | Protein Tob1 (Transducer of erbB-2 1) | ||||||||||
| Protein function | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which | ||||||||||
| PDB | 2D5R , 2Z15 , 5CI8 , 5CI9 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous. | ||||||||||
| Sequence |
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| Sequence length | 345 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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