PDIA6 (protein disulfide isomerase family A member 6)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
10130 |
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Protein disulfide isomerase family A member 6 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
PDIA6 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
ERP5, P5, TXNDC7 |
Chromosome
Chromosome number
|
2 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2p25.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically |
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
Transcription factors | |||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
Protein | ||||||||||||||||
UniProt ID | Q15084 | |||||||||||||||
Protein name | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | |||||||||||||||
Protein function | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed | |||||||||||||||
PDB | 1X5D , 3VWW , 3W8J , 4EF0 , 4GWR , 8CPQ | |||||||||||||||
Family and domains |
Pfam
|
|||||||||||||||
Tissue specificity | TISSUE SPECIFICITY: Expressed in platelets (at protein level). {ECO:0000269|PubMed:15466936}. | |||||||||||||||
Sequence |
|
|||||||||||||||
Sequence length | 440 | |||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|