Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10121
Gene name Gene Name - the full gene name approved by the HGNC.
Actin related protein 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACTR1A
Synonyms (NCBI Gene) Gene synonyms aliases
ARP1, Arp1A, CTRN1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q24.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000806 hsa-miR-15a-5p proteomics analysis 18362358
MIRT000805 hsa-miR-16-5p proteomics analysis 18362358
MIRT049187 hsa-miR-92a-3p CLASH 23622248
MIRT049187 hsa-miR-92a-3p CLASH 23622248
MIRT047006 hsa-miR-210-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0002177 Component Manchette IEA
GO:0005515 Function Protein binding IPI 28394342
GO:0005524 Function ATP binding IEA
GO:0005737 Component Cytoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605143 167 ENSG00000138107
Protein
UniProt ID P61163
Protein name Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Protein function Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00022 Actin 7 376 Actin Family
Sequence
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Motor proteins
Amyotrophic lateral sclerosis
Huntington disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection
  MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Ulcerative colitis Ulcerative colitis GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Leprosy Leprosy GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 36750132
Hepatoblastoma Inhibit 7784207
Insulin Resistance Stimulate 36750132
Mesothelioma Malignant Associate 18303113
Multiple Myeloma Associate 37587064
Neoplasms Associate 18303113
Polycystic Ovary Syndrome Associate 36750132