Gene Gene information from NCBI Gene database.
Entrez ID 10121
Gene name Actin related protein 1A
Gene symbol ACTR1A
Synonyms (NCBI Gene)
ARP1Arp1ACTRN1
Chromosome 10
Chromosome location 10q24.32
Summary This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions,
miRNA miRNA information provided by mirtarbase database.
781
miRTarBase ID miRNA Experiments Reference
MIRT000806 hsa-miR-15a-5p proteomics analysis 18362358
MIRT000805 hsa-miR-16-5p proteomics analysis 18362358
MIRT049187 hsa-miR-92a-3p CLASH 23622248
MIRT049187 hsa-miR-92a-3p CLASH 23622248
MIRT047006 hsa-miR-210-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005515 Function Protein binding IPI 28394342
GO:0005524 Function ATP binding IEA
GO:0005737 Component Cytoplasm IDA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605143 167 ENSG00000138107
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61163
Protein name Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Protein function Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00022 Actin 7 376 Actin Family
Sequence
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Motor proteins
Amyotrophic lateral sclerosis
Huntington disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection
  MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2