Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10107
Gene name Gene Name - the full gene name approved by the HGNC.	Tripartite motif containing 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRIM10
Synonyms (NCBI Gene) Gene synonyms aliases	HERF1, RFB30, RNF9
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Stud

Show/Hide all(100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT643366	hsa-miR-4426	HITS-CLIP	23824327
MIRT643365	hsa-miR-4647	HITS-CLIP	23824327
MIRT643364	hsa-miR-4662b	HITS-CLIP	23824327
MIRT643363	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT643362	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT643361	hsa-miR-591	HITS-CLIP	23824327
MIRT643360	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT643359	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT643358	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT643357	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT643356	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT643355	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT643353	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT643354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT643352	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT643351	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT643350	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT643349	hsa-miR-7641	HITS-CLIP	23824327
MIRT643348	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT616398	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT616397	hsa-miR-657	HITS-CLIP	23824327
MIRT616396	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT616395	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT616394	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT616393	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT572453	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT572452	hsa-miR-4762-5p	PAR-CLIP	20371350
MIRT572451	hsa-miR-1825	PAR-CLIP	20371350
MIRT572450	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT572449	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT572448	hsa-miR-4726-3p	PAR-CLIP	20371350
MIRT572447	hsa-miR-345-5p	PAR-CLIP	20371350
MIRT572446	hsa-miR-3182	PAR-CLIP	20371350
MIRT572445	hsa-miR-617	PAR-CLIP	20371350
MIRT572444	hsa-miR-6505-3p	PAR-CLIP	20371350
MIRT572443	hsa-miR-938	PAR-CLIP	20371350
MIRT572442	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT572441	hsa-miR-6740-3p	PAR-CLIP	20371350
MIRT572440	hsa-miR-3671	PAR-CLIP	20371350
MIRT572438	hsa-miR-4256	PAR-CLIP	20371350
MIRT572439	hsa-miR-607	PAR-CLIP	20371350
MIRT643366	hsa-miR-4426	HITS-CLIP	23824327
MIRT643365	hsa-miR-4647	HITS-CLIP	23824327
MIRT643364	hsa-miR-4662b	HITS-CLIP	23824327
MIRT643363	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT643362	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT643361	hsa-miR-591	HITS-CLIP	23824327
MIRT643360	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT643359	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT643358	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT643357	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT643356	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT643355	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT643353	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT643354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT643352	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT643351	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT643350	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT643349	hsa-miR-7641	HITS-CLIP	23824327
MIRT643348	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT616398	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT616397	hsa-miR-657	HITS-CLIP	23824327
MIRT616396	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT616395	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT616394	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT616393	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT572453	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT572452	hsa-miR-4762-5p	PAR-CLIP	20371350
MIRT572451	hsa-miR-1825	PAR-CLIP	20371350
MIRT572450	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT572449	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT572448	hsa-miR-4726-3p	PAR-CLIP	20371350
MIRT572447	hsa-miR-345-5p	PAR-CLIP	20371350
MIRT572446	hsa-miR-3182	PAR-CLIP	20371350
MIRT572445	hsa-miR-617	PAR-CLIP	20371350
MIRT572444	hsa-miR-6505-3p	PAR-CLIP	20371350
MIRT572443	hsa-miR-938	PAR-CLIP	20371350
MIRT572442	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT572441	hsa-miR-6740-3p	PAR-CLIP	20371350
MIRT572440	hsa-miR-3671	PAR-CLIP	20371350
MIRT572438	hsa-miR-4256	PAR-CLIP	20371350
MIRT572439	hsa-miR-607	PAR-CLIP	20371350
MIRT1452889	hsa-miR-3163	CLIP-seq
MIRT1452890	hsa-miR-345	CLIP-seq
MIRT1452891	hsa-miR-383	CLIP-seq
MIRT1452892	hsa-miR-4290	CLIP-seq
MIRT1452893	hsa-miR-4772-5p	CLIP-seq
MIRT1452894	hsa-miR-7	CLIP-seq
MIRT1452895	hsa-miR-873	CLIP-seq
MIRT2135657	hsa-miR-3909	CLIP-seq
MIRT2356866	hsa-miR-1229	CLIP-seq
MIRT1452890	hsa-miR-345	CLIP-seq
MIRT1452891	hsa-miR-383	CLIP-seq
MIRT1452893	hsa-miR-4772-5p	CLIP-seq
MIRT1452894	hsa-miR-7	CLIP-seq
MIRT1452895	hsa-miR-873	CLIP-seq
MIRT1452891	hsa-miR-383	CLIP-seq
MIRT1452893	hsa-miR-4772-5p	CLIP-seq
MIRT1452894	hsa-miR-7	CLIP-seq
MIRT1452895	hsa-miR-873	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	25416956, 31515488
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	ISS
GO:0008150	Process	Biological_process	ND
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0030218	Process	Erythrocyte differentiation	IEA
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0046597	Process	Negative regulation of viral entry into host cell	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635

MIM	HGNC	e!Ensembl
605701	10072	ENSG00000204613

Protein

UniProt ID

Q9UDY6

Protein name

Tripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9)

Protein function

E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (

PDB

7QS0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15227	zf-C3HC4_4	16 → 60		Domain
PF00643	zf-B_box	94 → 135	B-box zinc finger	Domain
PF13765	PRY	312 → 360	SPRY-associated domain	Family
PF00622	SPRY	364 → 481	SPRY domain	Family

Sequence

MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC
KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVV
CREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVST
KRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELE
EKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLEK
LCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHTGI
TGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPT
RLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLS
S

Sequence length

481

Interactions

View interactions

	Reactome
			Interferon gamma signaling

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Dermatitis	Dermatitis, Irritant	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	27258892
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	21725308
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	17804836, 19503088
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	28540026

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Psoriasis	Psoriasis	GWAS
Insomnia	Insomnia	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Diabetes Mellitus Type 1	Associate	19143812
Parkinson Disease	Associate	28586827

TRIM10 (tripartite motif containing 10)