TSPAN5 (tetraspanin 5)

Gene

• Entrez ID: 10098
• Gene name: Tetraspanin 5
• Gene symbol: TSPAN5
• Synonyms (NCBI Gene): NET-4, NET4, TM4SF9, TSPAN-5
• Chromosome: 4
• Chromosome location: 4q23
• Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018927	hsa-miR-335-5p	Microarray	18185580
MIRT1459856	hsa-miR-103a	CLIP-seq
MIRT1459857	hsa-miR-107	CLIP-seq
MIRT1459858	hsa-miR-1226	CLIP-seq
MIRT1459859	hsa-miR-15a	CLIP-seq
MIRT1459860	hsa-miR-15b	CLIP-seq
MIRT1459861	hsa-miR-16	CLIP-seq
MIRT1459862	hsa-miR-195	CLIP-seq
MIRT1459863	hsa-miR-208a	CLIP-seq
MIRT1459864	hsa-miR-208b	CLIP-seq
MIRT1459865	hsa-miR-2355-5p	CLIP-seq
MIRT1459866	hsa-miR-27a	CLIP-seq
MIRT1459867	hsa-miR-27b	CLIP-seq
MIRT1459868	hsa-miR-3138	CLIP-seq
MIRT1459869	hsa-miR-3145-3p	CLIP-seq
MIRT739247	hsa-miR-3179	CLIP-seq
MIRT1459870	hsa-miR-323-3p	CLIP-seq
MIRT1459871	hsa-miR-34b	CLIP-seq
MIRT1459872	hsa-miR-3616-3p	CLIP-seq
MIRT1459873	hsa-miR-424	CLIP-seq
MIRT1459874	hsa-miR-4310	CLIP-seq
MIRT1459875	hsa-miR-4311	CLIP-seq
MIRT1459876	hsa-miR-4318	CLIP-seq
MIRT1459877	hsa-miR-4328	CLIP-seq
MIRT1459878	hsa-miR-4459	CLIP-seq
MIRT1459879	hsa-miR-4468	CLIP-seq
MIRT1459880	hsa-miR-4639-3p	CLIP-seq
MIRT1459881	hsa-miR-4686	CLIP-seq
MIRT1459882	hsa-miR-4698	CLIP-seq
MIRT1459883	hsa-miR-4705	CLIP-seq
MIRT1459884	hsa-miR-4779	CLIP-seq
MIRT1459885	hsa-miR-497	CLIP-seq
MIRT1459886	hsa-miR-499-5p	CLIP-seq
MIRT1459887	hsa-miR-513a-5p	CLIP-seq
MIRT1459888	hsa-miR-513c	CLIP-seq
MIRT1459889	hsa-miR-514b-5p	CLIP-seq
MIRT1459890	hsa-miR-520d-5p	CLIP-seq
MIRT1459891	hsa-miR-524-5p	CLIP-seq
MIRT1459892	hsa-miR-556-3p	CLIP-seq
MIRT1459893	hsa-miR-665	CLIP-seq
MIRT1459894	hsa-miR-767-3p	CLIP-seq
MIRT1459895	hsa-miR-875-5p	CLIP-seq
MIRT1555229	hsa-miR-4778-5p	CLIP-seq
MIRT1555230	hsa-miR-485-3p	CLIP-seq
MIRT2138026	hsa-miR-1207-5p	CLIP-seq
MIRT2138027	hsa-miR-1246	CLIP-seq
MIRT2138028	hsa-miR-1253	CLIP-seq
MIRT2138029	hsa-miR-1297	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2138035	hsa-miR-26a	CLIP-seq
MIRT2138036	hsa-miR-26b	CLIP-seq
MIRT1459866	hsa-miR-27a	CLIP-seq
MIRT1459867	hsa-miR-27b	CLIP-seq
MIRT2138037	hsa-miR-3130-3p	CLIP-seq
MIRT2138038	hsa-miR-3134	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2138042	hsa-miR-3185	CLIP-seq
MIRT2138043	hsa-miR-3192	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2138045	hsa-miR-3689a-3p	CLIP-seq
MIRT2138046	hsa-miR-3689c	CLIP-seq
MIRT2138047	hsa-miR-3942-3p	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2138049	hsa-miR-4320	CLIP-seq
MIRT2138050	hsa-miR-4463	CLIP-seq
MIRT2138051	hsa-miR-4465	CLIP-seq
MIRT2138052	hsa-miR-4494	CLIP-seq
MIRT2138053	hsa-miR-455-5p	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT739246	hsa-miR-4728-5p	CLIP-seq
MIRT2138056	hsa-miR-4763-3p	CLIP-seq
MIRT2138057	hsa-miR-4793-3p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT1459887	hsa-miR-513a-5p	CLIP-seq
MIRT2138060	hsa-miR-544	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT2358928	hsa-miR-101	CLIP-seq
MIRT1459856	hsa-miR-103a	CLIP-seq
MIRT2358929	hsa-miR-106a	CLIP-seq
MIRT2358930	hsa-miR-106b	CLIP-seq
MIRT1459857	hsa-miR-107	CLIP-seq
MIRT2358931	hsa-miR-1207-3p	CLIP-seq
MIRT1459858	hsa-miR-1226	CLIP-seq
MIRT2358932	hsa-miR-1260	CLIP-seq
MIRT2358933	hsa-miR-1260b	CLIP-seq
MIRT2358934	hsa-miR-1287	CLIP-seq
MIRT2358935	hsa-miR-1299	CLIP-seq
MIRT2358936	hsa-miR-1301	CLIP-seq
MIRT2358937	hsa-miR-139-5p	CLIP-seq
MIRT2358938	hsa-miR-140-5p	CLIP-seq
MIRT2358939	hsa-miR-143	CLIP-seq
MIRT2358940	hsa-miR-144	CLIP-seq
MIRT2358941	hsa-miR-17	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2358942	hsa-miR-188-3p	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2358943	hsa-miR-20a	CLIP-seq
MIRT2358944	hsa-miR-20b	CLIP-seq
MIRT2358945	hsa-miR-29a	CLIP-seq
MIRT2358946	hsa-miR-29b	CLIP-seq
MIRT2358947	hsa-miR-29c	CLIP-seq
MIRT2358948	hsa-miR-3065-3p	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT739248	hsa-miR-3154	CLIP-seq
MIRT2358949	hsa-miR-3156-3p	CLIP-seq
MIRT2358950	hsa-miR-3164	CLIP-seq
MIRT739247	hsa-miR-3179	CLIP-seq
MIRT2358951	hsa-miR-3609	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2358954	hsa-miR-4301	CLIP-seq
MIRT1459875	hsa-miR-4311	CLIP-seq
MIRT1459876	hsa-miR-4318	CLIP-seq
MIRT2358955	hsa-miR-4427	CLIP-seq
MIRT2358956	hsa-miR-4431	CLIP-seq
MIRT2358957	hsa-miR-4447	CLIP-seq
MIRT2358958	hsa-miR-4472	CLIP-seq
MIRT2358959	hsa-miR-4488	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2138052	hsa-miR-4494	CLIP-seq
MIRT2358961	hsa-miR-4499	CLIP-seq
MIRT2358962	hsa-miR-4522	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2358963	hsa-miR-4697-5p	CLIP-seq
MIRT739246	hsa-miR-4728-5p	CLIP-seq
MIRT2358964	hsa-miR-4733-3p	CLIP-seq
MIRT2358965	hsa-miR-4756-3p	CLIP-seq
MIRT2358966	hsa-miR-4760-3p	CLIP-seq
MIRT2358967	hsa-miR-4770	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2358969	hsa-miR-4795-5p	CLIP-seq
MIRT2358970	hsa-miR-4796-3p	CLIP-seq
MIRT2358971	hsa-miR-4797-5p	CLIP-seq
MIRT2358972	hsa-miR-486-3p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2358973	hsa-miR-5047	CLIP-seq
MIRT2358974	hsa-miR-519d	CLIP-seq
MIRT2358975	hsa-miR-541	CLIP-seq
MIRT2358976	hsa-miR-548ah	CLIP-seq
MIRT2358977	hsa-miR-548v	CLIP-seq
MIRT2358978	hsa-miR-628-5p	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2358979	hsa-miR-654-5p	CLIP-seq
MIRT2358980	hsa-miR-7	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT2358981	hsa-miR-875-3p	CLIP-seq
MIRT2358982	hsa-miR-93	CLIP-seq
MIRT2358983	hsa-miR-936	CLIP-seq
MIRT1459856	hsa-miR-103a	CLIP-seq
MIRT1459857	hsa-miR-107	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2396424	hsa-miR-4513	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2652179	hsa-miR-1252	CLIP-seq
MIRT2652180	hsa-miR-146a	CLIP-seq
MIRT2652181	hsa-miR-146b-5p	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2652182	hsa-miR-1912	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2652183	hsa-miR-2276	CLIP-seq
MIRT2652184	hsa-miR-28-5p	CLIP-seq
MIRT2652185	hsa-miR-3064-5p	CLIP-seq
MIRT2652186	hsa-miR-3128	CLIP-seq
MIRT2652187	hsa-miR-3139	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2652188	hsa-miR-3180-5p	CLIP-seq
MIRT2652189	hsa-miR-3187-3p	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2652190	hsa-miR-3692	CLIP-seq
MIRT2652191	hsa-miR-3925-5p	CLIP-seq
MIRT2652192	hsa-miR-3973	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2652193	hsa-miR-4279	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2652194	hsa-miR-4420	CLIP-seq
MIRT2652195	hsa-miR-4452	CLIP-seq
MIRT2652196	hsa-miR-4470	CLIP-seq
MIRT2652197	hsa-miR-4474-5p	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2652198	hsa-miR-4529-5p	CLIP-seq
MIRT2138053	hsa-miR-455-5p	CLIP-seq
MIRT2652199	hsa-miR-4633-3p	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2652200	hsa-miR-4762-5p	CLIP-seq
MIRT2652201	hsa-miR-4772-3p	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2652202	hsa-miR-4793-5p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2652203	hsa-miR-520a-5p	CLIP-seq
MIRT2652204	hsa-miR-525-5p	CLIP-seq
MIRT2652205	hsa-miR-548l	CLIP-seq
MIRT2652206	hsa-miR-604	CLIP-seq
MIRT2652207	hsa-miR-630	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2652208	hsa-miR-647	CLIP-seq
MIRT2652209	hsa-miR-708	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT1459895	hsa-miR-875-5p	CLIP-seq
MIRT2652210	hsa-miR-934	CLIP-seq
MIRT2652179	hsa-miR-1252	CLIP-seq
MIRT2652180	hsa-miR-146a	CLIP-seq
MIRT2652181	hsa-miR-146b-5p	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2652183	hsa-miR-2276	CLIP-seq
MIRT2652184	hsa-miR-28-5p	CLIP-seq
MIRT2652185	hsa-miR-3064-5p	CLIP-seq
MIRT2652187	hsa-miR-3139	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2652189	hsa-miR-3187-3p	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2652190	hsa-miR-3692	CLIP-seq
MIRT2652191	hsa-miR-3925-5p	CLIP-seq
MIRT2652192	hsa-miR-3973	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2652197	hsa-miR-4474-5p	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2652198	hsa-miR-4529-5p	CLIP-seq
MIRT2652199	hsa-miR-4633-3p	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2652201	hsa-miR-4772-3p	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2652202	hsa-miR-4793-5p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2652205	hsa-miR-548l	CLIP-seq
MIRT2652206	hsa-miR-604	CLIP-seq
MIRT2652207	hsa-miR-630	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2652208	hsa-miR-647	CLIP-seq
MIRT2652209	hsa-miR-708	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT1459895	hsa-miR-875-5p	CLIP-seq
MIRT2652210	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23091066, 26686862, 31792032, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23091066, 31792032
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0008104	Process	Intracellular protein localization	IEA
GO:0016020	Component	Membrane	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0019899	Function	Enzyme binding	IPI	23091066
GO:0045747	Process	Positive regulation of Notch signaling pathway	IMP	23091066
GO:0051043	Process	Regulation of membrane protein ectodomain proteolysis	IDA	28600292, 31792032
GO:0051604	Process	Protein maturation	IEA
GO:0051604	Process	Protein maturation	IMP	23091066
GO:0072659	Process	Protein localization to plasma membrane	IMP	23091066

Other IDs

• MIM: 613136
• HGNC: 17753
• e!Ensembl: ENSG00000168785

Protein

• UniProt ID: P62079
• Protein name: Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
• Protein function: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell sur
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	15 → 260	Tetraspanin family	Family

• Sequence:

  MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFD
  PVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIK
  DQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERC
  GVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIF
  IGIALLQIFGICLAQNLVSDIEAVRASW

• Sequence length: 268

Pathways

Reactome:

Amyloid fiber formation

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Gastric cancer	Uncertain significance	rs751414387	RCV005929065
Lung cancer	Uncertain significance	rs751414387	RCV005929066
Prostate cancer	Uncertain significance	rs193921080	RCV000149175

Associations from Text Mining
Disease Name	Relationship Type	References
Alcoholism	Associate	32753686
Bone Diseases Metabolic	Associate	36728938
Carcinoma Hepatocellular	Associate	33955149
Colorectal Neoplasms	Stimulate	37047447
Depressive Disorder Major	Associate	26903268, 32753686
Fallopian Tube Diseases	Associate	29908376
Familial Primary Pulmonary Hypertension	Associate	34722766
Histiocytosis Langerhans Cell	Associate	36714021
Juvenile osteoporosis	Associate	29750314
Neoplasm Metastasis	Associate	33955149
Neoplasms	Associate	33955149
Pregnancy Tubal	Associate	29908376