Gene Gene information from NCBI Gene database.
Entrez ID 10097
Gene name Actin related protein 2
Gene symbol ACTR2
Synonyms (NCBI Gene)
ARP2
Chromosome 2
Chromosome location 2p14
Summary The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamel
miRNA miRNA information provided by mirtarbase database.
1289
miRTarBase ID miRNA Experiments Reference
MIRT020780 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT021852 hsa-miR-132-3p Microarray 17612493
MIRT024581 hsa-miR-215-5p Microarray 19074876
MIRT026515 hsa-miR-192-5p Microarray 19074876
MIRT028015 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003779 Function Actin binding IEA
GO:0005200 Function Structural constituent of cytoskeleton IDA 11741539
GO:0005515 Function Protein binding IPI 29058690, 32128961
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604221 169 ENSG00000138071
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61160
Protein name Actin-related protein 2 (Actin-like protein 2)
Protein function ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks i
PDB 6UHC , 6YW6 , 6YW7 , 8P94
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00022 Actin 3 390 Actin Family
Sequence
Sequence length 394
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
Tight junction
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection
  Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation
Clathrin-mediated endocytosis
FCGR3A-mediated phagocytosis
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Lung cancer Uncertain significance rs779587590 RCV005930898
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 36439123
Arthritis Rheumatoid Associate 36924774
Blood Platelet Disorders Associate 28368018
Carcinogenesis Associate 14990971
Carcinoma Non Small Cell Lung Associate 32169900
Carcinoma Squamous Cell Associate 35955862
Colorectal Neoplasms Associate 14990971, 17459058
Deafness Associate 22718764
Diabetic Nephropathies Associate 37681455
Fibrosis Associate 35449370, 36069177, 37681455