CDH10 (cadherin 10)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 1008
Gene name Cadherin 10
Gene symbol CDH10
Synonyms (NCBI Gene)
-
Chromosome 5
Chromosome location 5p14.2-p14.1
Summary This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the
miRNA miRNA information provided by mirtarbase database.
5
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (5)
miRTarBase ID miRNA Experiments Reference
MIRT879290 hsa-miR-3163 CLIP-seq
MIRT879291 hsa-miR-3662 CLIP-seq
MIRT879292 hsa-miR-432 CLIP-seq
MIRT879293 hsa-miR-450b-5p CLIP-seq
MIRT879294 hsa-miR-579 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
GO:0005912 Component Adherens junction IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604555 1749 ENSG00000040731
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6N8
Protein name Cadherin-10 (T2-cadherin)
Protein function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00028 Cadherin 60 → 151 Cadherin domain Domain
PF00028 Cadherin 165 → 260 Cadherin domain Domain
PF00028 Cadherin 274 → 376 Cadherin domain Domain
PF00028 Cadherin 389 → 480 Cadherin domain Domain
PF00028 Cadherin 493 → 587 Cadherin domain Domain
PF01049 Cadherin_C 635 → 782 Cadherin cytoplasmic region Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung. {ECO:0000269|PubMed:10386616}.
Sequence
Sequence length 788
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Adherens junctions interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CDH10-related condition Uncertain significance rs139913021 RCV005356325
Show/Hide Text Mining Associations (20)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Autism Spectrum Disorder Associate 19404256, 28281572, 33076578
Carcinogenesis Associate 28124395
Carcinoma Pancreatic Ductal Associate 28124395
Carcinoma Squamous Cell Associate 26503331
Colorectal Neoplasms Associate 24898286, 24951259
Death Associate 18711181
Endometrial Neoplasms Associate 28448305
Heart Defects Congenital Associate 30342662
Hyperkeratosis Epidermolytic Inhibit 35421402
Lung Diseases Associate 28448305