Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10018
Gene name Gene Name - the full gene name approved by the HGNC.
BCL2 like 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BCL2L11
Synonyms (NCBI Gene) Gene synonyms aliases
BAM, BIM, BOD
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003739 hsa-miR-32-5p Luciferase reporter assay 18676839
MIRT003739 hsa-miR-32-5p qRT-PCR 18676839
MIRT001206 hsa-miR-17-5p Luciferase reporter assay, Western blot 19136465
MIRT001206 hsa-miR-17-5p Luciferase reporter assay, Western blot 19136465
MIRT001206 hsa-miR-17-5p Luciferase reporter assay, Western blot 19136465
Transcription factors
Transcription factor Regulation Reference
CREB1 Unknown 20367563
FOXO3 Unknown 21654193
NFKB1 Repression 18223231
RELA Repression 18223231
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0001782 Process B cell homeostasis IEA
GO:0001783 Process B cell apoptotic process IEA
GO:0001822 Process Kidney development IEA
GO:0001844 Process Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603827 994 ENSG00000153094
Protein
UniProt ID O43521
Protein name Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)
Protein function Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-ga
PDB 1F95 , 2K7W , 2NL9 , 2V6Q , 2VM6 , 2WH6 , 2YQ6 , 2YQ7 , 3D7V , 3FDL , 3IO8 , 3IO9 , 3KJ0 , 3KJ1 , 3KJ2 , 4A1U , 4A1W , 4B4S , 4D2M , 4QVF , 4UF3 , 4YJ4 , 4ZIE , 4ZIF , 4ZIH , 5AGW , 5AGX , 5C3G , 5VWV , 5VWW , 5VWX , 5VWY , 5VWZ , 5VX0 , 5VX2 , 5VX3 , 5WOS , 6QFI , 6RJP , 6TQQ , 6UA3 , 6UAB , 6VBX , 6X8O , 8T5E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06773 Bim_N 4 40 Bim protein N-terminus Family
PF08945 Bclx_interact 132 166 Bcl-x interacting, BH3 domain Domain
Tissue specificity TISSUE SPECIFICITY: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in sple
Sequence
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSP
QGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPP
CQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPR
MVILRLLRYIVRLVWRMH
Sequence length 198
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
FoxO signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Apoptosis - multiple species
Non-alcoholic fatty liver disease
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Colorectal cancer
  Activation of BIM and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
Signaling by BRAF and RAF fusions
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
RUNX3 regulates BCL2L11 (BIM) transcription
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
28869590
Prostate cancer Prostate carcinoma, Prostate cancer, familial rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 29892016
Prostate cancer, hereditary PROSTATE CANCER, HEREDITARY, 1 rs387906327, rs193929331, rs74315365, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466 29892016
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Diabetes Diabetes GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Lymphocytic Leukemia Lymphocytic Leukemia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 25527700
Adenocarcinoma Associate 20348947
Adenocarcinoma of Lung Associate 25791936, 26639561
Adenoma Associate 20348947
Adenoma Pleomorphic Associate 28941993
Adenoma Pleomorphic Stimulate 31488082
Adenomatous Polyposis Coli Associate 22399804
Alzheimer Disease Associate 32844279
Arthritis Rheumatoid Associate 20878914, 39930543
Arthropathy progressive pseudorheumatoid of childhood Associate 28941993