Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	10016
Gene name	Programmed cell death 6
Gene symbol	PDCD6
Synonyms (NCBI Gene)	ALG-2ALG2PEF1B
Chromosome	5
Chromosome location	5p15.33
Summary	This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005725	hsa-miR-183-5p	qRT-PCR	20602797
MIRT040945	hsa-miR-18a-3p	CLASH	23622248
MIRT440016	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440016	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1219454	hsa-miR-1207-3p	CLIP-seq
MIRT1219455	hsa-miR-137	CLIP-seq
MIRT1219456	hsa-miR-183	CLIP-seq
MIRT1219457	hsa-miR-21	CLIP-seq
MIRT1219458	hsa-miR-218	CLIP-seq
MIRT1219459	hsa-miR-3124-3p	CLIP-seq
MIRT1219460	hsa-miR-338-5p	CLIP-seq
MIRT1219461	hsa-miR-346	CLIP-seq
MIRT1219462	hsa-miR-412	CLIP-seq
MIRT1219463	hsa-miR-4286	CLIP-seq
MIRT1219464	hsa-miR-4288	CLIP-seq
MIRT1219465	hsa-miR-4504	CLIP-seq
MIRT1219466	hsa-miR-4509	CLIP-seq
MIRT1219467	hsa-miR-4666-3p	CLIP-seq
MIRT1219468	hsa-miR-4684-3p	CLIP-seq
MIRT1219469	hsa-miR-4704-3p	CLIP-seq
MIRT1219470	hsa-miR-4716-5p	CLIP-seq
MIRT1219471	hsa-miR-4744	CLIP-seq
MIRT1219472	hsa-miR-4773	CLIP-seq
MIRT1219473	hsa-miR-4777-3p	CLIP-seq
MIRT1219474	hsa-miR-518a-5p	CLIP-seq
MIRT1219475	hsa-miR-527	CLIP-seq
MIRT1219476	hsa-miR-548aa	CLIP-seq
MIRT1219477	hsa-miR-582-5p	CLIP-seq
MIRT1219478	hsa-miR-587	CLIP-seq
MIRT1219479	hsa-miR-590-5p	CLIP-seq
MIRT1219480	hsa-miR-598	CLIP-seq
MIRT1219481	hsa-miR-632	CLIP-seq
MIRT1219482	hsa-miR-654-3p	CLIP-seq
MIRT1219483	hsa-miR-662	CLIP-seq
MIRT1219454	hsa-miR-1207-3p	CLIP-seq
MIRT1219463	hsa-miR-4286	CLIP-seq
MIRT1219454	hsa-miR-1207-3p	CLIP-seq
MIRT2063428	hsa-miR-136	CLIP-seq
MIRT1219455	hsa-miR-137	CLIP-seq
MIRT2063429	hsa-miR-1914	CLIP-seq
MIRT1219457	hsa-miR-21	CLIP-seq
MIRT1219458	hsa-miR-218	CLIP-seq
MIRT1219459	hsa-miR-3124-3p	CLIP-seq
MIRT2063430	hsa-miR-3130-3p	CLIP-seq
MIRT1219460	hsa-miR-338-5p	CLIP-seq
MIRT1219461	hsa-miR-346	CLIP-seq
MIRT2063431	hsa-miR-3914	CLIP-seq
MIRT2063432	hsa-miR-3938	CLIP-seq
MIRT1219462	hsa-miR-412	CLIP-seq
MIRT1219464	hsa-miR-4288	CLIP-seq
MIRT1219465	hsa-miR-4504	CLIP-seq
MIRT1219467	hsa-miR-4666-3p	CLIP-seq
MIRT1219469	hsa-miR-4704-3p	CLIP-seq
MIRT1219470	hsa-miR-4716-5p	CLIP-seq
MIRT1219472	hsa-miR-4773	CLIP-seq
MIRT2063433	hsa-miR-507	CLIP-seq
MIRT2063434	hsa-miR-542-3p	CLIP-seq
MIRT2063435	hsa-miR-557	CLIP-seq
MIRT1219478	hsa-miR-587	CLIP-seq
MIRT1219479	hsa-miR-590-5p	CLIP-seq
MIRT1219480	hsa-miR-598	CLIP-seq
MIRT1219481	hsa-miR-632	CLIP-seq
MIRT2063436	hsa-miR-642a	CLIP-seq
MIRT1219482	hsa-miR-654-3p	CLIP-seq
MIRT1219454	hsa-miR-1207-3p	CLIP-seq
MIRT1219455	hsa-miR-137	CLIP-seq
MIRT1219456	hsa-miR-183	CLIP-seq
MIRT2291895	hsa-miR-204	CLIP-seq
MIRT1219457	hsa-miR-21	CLIP-seq
MIRT2291896	hsa-miR-211	CLIP-seq
MIRT2063430	hsa-miR-3130-3p	CLIP-seq
MIRT2291897	hsa-miR-3143	CLIP-seq
MIRT2291898	hsa-miR-323-3p	CLIP-seq
MIRT1219460	hsa-miR-338-5p	CLIP-seq
MIRT1219461	hsa-miR-346	CLIP-seq
MIRT2063432	hsa-miR-3938	CLIP-seq
MIRT1219463	hsa-miR-4286	CLIP-seq
MIRT1219464	hsa-miR-4288	CLIP-seq
MIRT2291899	hsa-miR-4325	CLIP-seq
MIRT2291900	hsa-miR-4422	CLIP-seq
MIRT1219465	hsa-miR-4504	CLIP-seq
MIRT1219466	hsa-miR-4509	CLIP-seq
MIRT1219467	hsa-miR-4666-3p	CLIP-seq
MIRT1219469	hsa-miR-4704-3p	CLIP-seq
MIRT1219471	hsa-miR-4744	CLIP-seq
MIRT2291901	hsa-miR-4755-5p	CLIP-seq
MIRT1219472	hsa-miR-4773	CLIP-seq
MIRT1219473	hsa-miR-4777-3p	CLIP-seq
MIRT2291902	hsa-miR-494	CLIP-seq
MIRT2063433	hsa-miR-507	CLIP-seq
MIRT2291903	hsa-miR-543	CLIP-seq
MIRT1219476	hsa-miR-548aa	CLIP-seq
MIRT2063435	hsa-miR-557	CLIP-seq
MIRT1219479	hsa-miR-590-5p	CLIP-seq
MIRT1219480	hsa-miR-598	CLIP-seq
MIRT2291904	hsa-miR-623	CLIP-seq
MIRT1219481	hsa-miR-632	CLIP-seq
MIRT1219482	hsa-miR-654-3p	CLIP-seq
MIRT1219483	hsa-miR-662	CLIP-seq
MIRT1219457	hsa-miR-21	CLIP-seq
MIRT1219458	hsa-miR-218	CLIP-seq
MIRT1219459	hsa-miR-3124-3p	CLIP-seq
MIRT1219462	hsa-miR-412	CLIP-seq
MIRT1219470	hsa-miR-4716-5p	CLIP-seq
MIRT1219478	hsa-miR-587	CLIP-seq
MIRT1219479	hsa-miR-590-5p	CLIP-seq
MIRT1219461	hsa-miR-346	CLIP-seq
MIRT1219464	hsa-miR-4288	CLIP-seq
MIRT1219481	hsa-miR-632	CLIP-seq
MIRT1219482	hsa-miR-654-3p	CLIP-seq
MIRT2063428	hsa-miR-136	CLIP-seq
MIRT1219456	hsa-miR-183	CLIP-seq
MIRT2063429	hsa-miR-1914	CLIP-seq
MIRT1219458	hsa-miR-218	CLIP-seq
MIRT1219459	hsa-miR-3124-3p	CLIP-seq
MIRT2063430	hsa-miR-3130-3p	CLIP-seq
MIRT2291898	hsa-miR-323-3p	CLIP-seq
MIRT1219461	hsa-miR-346	CLIP-seq
MIRT2063432	hsa-miR-3938	CLIP-seq
MIRT1219462	hsa-miR-412	CLIP-seq
MIRT1219464	hsa-miR-4288	CLIP-seq
MIRT1219466	hsa-miR-4509	CLIP-seq
MIRT1219469	hsa-miR-4704-3p	CLIP-seq
MIRT1219470	hsa-miR-4716-5p	CLIP-seq
MIRT1219471	hsa-miR-4744	CLIP-seq
MIRT1219472	hsa-miR-4773	CLIP-seq
MIRT1219473	hsa-miR-4777-3p	CLIP-seq
MIRT2291902	hsa-miR-494	CLIP-seq
MIRT1219478	hsa-miR-587	CLIP-seq
MIRT1219481	hsa-miR-632	CLIP-seq
MIRT2063436	hsa-miR-642a	CLIP-seq
MIRT1219482	hsa-miR-654-3p	CLIP-seq
MIRT2589569	hsa-miR-760	CLIP-seq
MIRT2063428	hsa-miR-136	CLIP-seq
MIRT1219456	hsa-miR-183	CLIP-seq
MIRT2063429	hsa-miR-1914	CLIP-seq
MIRT1219458	hsa-miR-218	CLIP-seq
MIRT1219459	hsa-miR-3124-3p	CLIP-seq
MIRT2063430	hsa-miR-3130-3p	CLIP-seq
MIRT2291898	hsa-miR-323-3p	CLIP-seq
MIRT1219461	hsa-miR-346	CLIP-seq
MIRT2063431	hsa-miR-3914	CLIP-seq
MIRT2063432	hsa-miR-3938	CLIP-seq
MIRT1219462	hsa-miR-412	CLIP-seq
MIRT1219464	hsa-miR-4288	CLIP-seq
MIRT1219466	hsa-miR-4509	CLIP-seq
MIRT1219469	hsa-miR-4704-3p	CLIP-seq
MIRT1219470	hsa-miR-4716-5p	CLIP-seq
MIRT1219471	hsa-miR-4744	CLIP-seq
MIRT1219472	hsa-miR-4773	CLIP-seq
MIRT1219473	hsa-miR-4777-3p	CLIP-seq
MIRT2291902	hsa-miR-494	CLIP-seq
MIRT1219478	hsa-miR-587	CLIP-seq
MIRT1219481	hsa-miR-632	CLIP-seq
MIRT2063436	hsa-miR-642a	CLIP-seq
MIRT1219482	hsa-miR-654-3p	CLIP-seq
MIRT2589569	hsa-miR-760	CLIP-seq

Show/Hide all (61)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0001525	Process	Angiogenesis	IEA
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IDA	21893193
GO:0005509	Function	Calcium ion binding	IDA	25667979
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	11883939, 12445460, 16132846, 16189514, 17174262, 17196169, 18256029, 18940611, 21893193, 21988832, 23924735, 25416956, 25667979, 25910212, 26950892, 27716508, 27784779, 27813252, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	11278427, 16957052, 17045351, 17196169, 21122810, 27784779
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	11278427, 14999017, 17045351, 17196169, 21122810, 27784779
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	17196169
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006886	Process	Intracellular protein transport	IDA	21122810
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	27716508, 27813252
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IDA	21893193
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0014029	Process	Neural crest formation	IMP	27716508
GO:0014032	Process	Neural crest cell development	IMP	27716508
GO:0016020	Component	Membrane	IEA
GO:0030127	Component	COPII vesicle coat	IDA	27716508
GO:0030674	Function	Protein-macromolecule adaptor activity	IMP	19520058
GO:0030948	Process	Negative regulation of vascular endothelial growth factor receptor signaling pathway	IDA	21893193
GO:0031410	Component	Cytoplasmic vesicle	IDA	21122810
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IDA	27716508
GO:0032007	Process	Negative regulation of TOR signaling	IDA	21893193
GO:0034605	Process	Cellular response to heat	IDA	21122810
GO:0036324	Process	Vascular endothelial growth factor receptor-2 signaling pathway	IDA	21893193
GO:0042802	Function	Identical protein binding	IPI	16189514, 18940611, 21988832, 25416956
GO:0042803	Function	Protein homodimerization activity	IDA	25667979
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	16132846
GO:0043495	Function	Protein-membrane adaptor activity	IMP	16957052
GO:0045766	Process	Positive regulation of angiogenesis	IDA	21893193
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	11278427
GO:0046983	Function	Protein dimerization activity	IEA
GO:0046983	Function	Protein dimerization activity	IPI	11883899
GO:0048208	Process	COPII vesicle coating	IMP	27716508
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IMP	14999017
GO:0048306	Function	Calcium-dependent protein binding	IPI	12445460, 16957052, 17045351, 17196169, 17214967, 18256029, 23924735, 27716508
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17196169
GO:0051592	Process	Response to calcium ion	IDA	12445460, 17196169
GO:0051592	Process	Response to calcium ion	IEA
GO:0051592	Process	Response to calcium ion	ISS
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	21893193
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070971	Component	Endoplasmic reticulum exit site	IDA	27813252
GO:0070971	Component	Endoplasmic reticulum exit site	IMP	16957052
GO:0097190	Process	Apoptotic signaling pathway	TAS	8560270
GO:1902527	Process	Positive regulation of protein monoubiquitination	IMP	27716508
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IMP	27716508

MIM	HGNC	e!Ensembl
601057	8765	ENSG00000249915

O75340

Protein name

Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)

Protein function

Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein comple

PDB

2ZN8 , 2ZN9 , 2ZND , 2ZNE , 2ZRS , 2ZRT , 3AAJ , 3AAK , 3WXA , 5GQQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13202	EF-hand_5	30 → 53	EF hand	Domain
PF13499	EF-hand_7	92 → 156	EF-hand domain pair	Domain

Sequence

MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPF
NPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALS
GFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSY
EQYLSMVFSIV

Sequence length

191

Interactions

View interactions

PDCD6 (programmed cell death 6)