Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10000
Gene name Gene Name - the full gene name approved by the HGNC.
AKT serine/threonine kinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AKT3
Synonyms (NCBI Gene) Gene synonyms aliases
MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MPPH2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q43-q44
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of b
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs397514605 T>C Pathogenic Coding sequence variant, missense variant, genic upstream transcript variant
rs397514606 C>T Pathogenic Coding sequence variant, 5 prime UTR variant, missense variant, genic upstream transcript variant
rs587776935 G>A Likely-pathogenic, pathogenic Genic downstream transcript variant, coding sequence variant, missense variant, intron variant
rs886041100 A>T Likely-pathogenic Missense variant, coding sequence variant, genic upstream transcript variant
rs1064795602 C>T Pathogenic Genic downstream transcript variant, missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003099 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003334 hsa-miR-15a-5p Review 20026422
MIRT003329 hsa-miR-16-5p Review 20026422
MIRT006197 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
MIRT006197 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000002 Process Mitochondrial genome maintenance IMP 18524868
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 25323119
GO:0004672 Function Protein kinase activity TAS 10092583
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 16540465
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611223 393 ENSG00000117020
Protein
UniProt ID Q9Y243
Protein name RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Protein function AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated throug
PDB 2X18 , 8ZXW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 6 107 PH domain Domain
PF00069 Pkinase 148 405 Protein kinase domain Domain
PF00433 Pkinase_C 426 473 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
Sequence
Sequence length 479
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Neutrophil extracellular trap formation
Toll-like receptor signaling pathway
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Neurotrophin signaling pathway
Cholinergic synapse
Dopaminergic synapse
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Relaxin signaling pathway
GnRH secretion
Insulin resistance
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Alcoholic liver disease
Carbohydrate digestion and absorption
Alzheimer disease
Spinocerebellar ataxia
Shigellosis
Salmonella infection
Yersinia infection
Chagas disease
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Human cytomegalovirus infection
Influenza A
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Proteoglycans in cancer
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
Regulation of PTEN stability and activity
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
Glioblastoma Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Glioma Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499
View all (13 more)
28346443
Hemimegalencephaly Hemimegalencephaly rs1057519914, rs1554438588 22500628
Unknown
Disease term Disease name Evidence References Source
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome GenCC
Megalencephaly, Polymicrogyria, Polydactyly, Hydrocephalus Syndrome megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 GenCC
Microcephaly microcephaly GenCC
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 33220166
Atherosclerosis Associate 34103010
Autistic Disorder Associate 28969385
Brain Diseases Associate 36226386
Breast Neoplasms Associate 10419456, 22722202, 23929892, 25927147, 27297869, 28160548, 29636477, 31781306, 32444848, 37834358, 40403210
Burkitt Lymphoma Associate 19759907
Carcinogenesis Associate 28733453
Carcinoma Hepatocellular Associate 25424347, 26002580, 33289700, 38033034
Carcinoma Non Small Cell Lung Associate 30280779, 30873868, 34313353, 34596822
Carcinoma Ovarian Epithelial Associate 26909918