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Gene Gene information from NCBI Gene database.
Entrez ID 7529
Gene name Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Gene symbol YWHAB
Synonyms (NCBI Gene)
GW128HEL-S-1HS1KCIP-1YWHAA
Chromosome 20
Chromosome location 20q13.12
Summary This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded pro
miRNA miRNA information provided by mirtarbase database.
1245 Show/Hide all (1245)
miRTarBase ID miRNA Experiments Reference
MIRT046917 hsa-miR-221-3p CLASH 23622248
MIRT044012 hsa-miR-378a-5p CLASH 23622248
MIRT037014 hsa-miR-877-3p CLASH 23622248
MIRT035990 hsa-miR-1301-3p CLASH 23622248
MIRT641784 hsa-miR-4457 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37 Show/Hide all (37)
GO ID Ontology Definition Evidence Reference
GO:0004860 Function Protein kinase inhibitor activity IDA 11555644
GO:0004864 Function Protein phosphatase inhibitor activity IDA 17255105
GO:0005515 Function Protein binding IPI 7644510, 7882972, 7935795, 8085158, 9341175, 10713667, 10958686, 11157475, 11555644, 11697890, 11886850, 12582162, 12620389, 12963375, 14688255, 14701738, 14743216, 15023544, 15159416, 15454081, 15691829, 15860732, 15883195, 16367866, 16672054, 16672277, 16775625, 16868027, 16959763
GO:0005634 Component Nucleus IDA 31906564
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601289 12849 ENSG00000166913
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P31946
Protein name 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally resu
PDB 2BQ0 , 2C23 , 4DNK , 5N10 , 6A5Q , 6BYK , 6GN0 , 6GN8 , 6GNJ , 6GNK , 6GNN , 6HEP , 8DP5 , 8EQ8 , 8EQH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 11 → 231 14-3-3 protein Domain
Sequence
Sequence length 246
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Cell cycle Activation of BAD and translocation to mitochondria
Oocyte meiosis mTOR signalling
PI3K-Akt signaling pathway mTORC1-mediated signalling
Hippo signaling pathway Frs2-mediated activation
Hepatitis C Signaling by Hippo
Hepatitis B Rap1 signalling
Viral carcinogenesis Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  RHO GTPases activate PKNs
  TP53 Regulates Metabolic Genes
  RAF activation
  MAP2K and MAPK activation
  Negative regulation of MAPK pathway
  Signaling by moderate kinase activity BRAF mutants
  Signaling by high-kinase activity BRAF mutants
  Signaling by BRAF and RAF fusions
  Paradoxical activation of RAF signaling by kinase inactive BRAF
  Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
  Regulation of localization of FOXO transcription factors
  Signaling downstream of RAS mutants
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
SCHIZOPHRENIA — GWAS catalog 35396580
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (19)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16369491
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Sickle Cell Sickle cell anemia Pubtator 19650141 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 27527857 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 27039779 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 31387239 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Degenerative polyarthritis Arthritis BEFREE 29749466
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 22575386 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Hypoxia Hypoxia Pubtator 29180379 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Idiopathic pulmonary arterial hypertension Pulmonary arterial hypertension BEFREE 30317584
★★★★★
★☆☆☆☆
Found in Text Mining only
Idiopathic pulmonary hypertension Pulmonary Hypertension BEFREE 30317584
★★★★★
★☆☆☆☆
Found in Text Mining only