XYLB (xylulokinase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9942
• Gene name: Xylulokinase
• Gene symbol: XYLB
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3p22.2
• Summary: The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include f

miRNA Show/Hide all (140)

miRTarBase ID	miRNA	Experiments	Reference
MIRT484736	hsa-miR-889-3p	PAR-CLIP	23592263
MIRT484735	hsa-miR-183-3p	PAR-CLIP	23592263
MIRT484734	hsa-miR-4452	PAR-CLIP	23592263
MIRT484732	hsa-miR-8081	PAR-CLIP	23592263
MIRT484736	hsa-miR-889-3p	PAR-CLIP	23592263
MIRT484735	hsa-miR-183-3p	PAR-CLIP	23592263
MIRT484734	hsa-miR-4452	PAR-CLIP	23592263
MIRT484732	hsa-miR-8081	PAR-CLIP	23592263
MIRT1497679	hsa-miR-1184	CLIP-seq
MIRT1497680	hsa-miR-1205	CLIP-seq
MIRT1497681	hsa-miR-1245b-5p	CLIP-seq
MIRT1497682	hsa-miR-1255a	CLIP-seq
MIRT1497683	hsa-miR-1255b	CLIP-seq
MIRT1497684	hsa-miR-1265	CLIP-seq
MIRT1497685	hsa-miR-1270	CLIP-seq
MIRT1497686	hsa-miR-1286	CLIP-seq
MIRT1497687	hsa-miR-1299	CLIP-seq
MIRT1497688	hsa-miR-1305	CLIP-seq
MIRT1497689	hsa-miR-2116	CLIP-seq
MIRT1497690	hsa-miR-2392	CLIP-seq
MIRT1497691	hsa-miR-296-3p	CLIP-seq
MIRT1497692	hsa-miR-3115	CLIP-seq
MIRT1497693	hsa-miR-3142	CLIP-seq
MIRT1497694	hsa-miR-3145-5p	CLIP-seq
MIRT1497695	hsa-miR-3158-5p	CLIP-seq
MIRT1497696	hsa-miR-3189-3p	CLIP-seq
MIRT1497697	hsa-miR-3616-5p	CLIP-seq
MIRT1497698	hsa-miR-3647-5p	CLIP-seq
MIRT1497699	hsa-miR-3671	CLIP-seq
MIRT1497700	hsa-miR-3690	CLIP-seq
MIRT1497701	hsa-miR-4254	CLIP-seq
MIRT1497702	hsa-miR-4299	CLIP-seq
MIRT1497703	hsa-miR-4311	CLIP-seq
MIRT1497704	hsa-miR-4426	CLIP-seq
MIRT1497705	hsa-miR-4433	CLIP-seq
MIRT1497706	hsa-miR-4434	CLIP-seq
MIRT1497707	hsa-miR-4456	CLIP-seq
MIRT1497708	hsa-miR-4481	CLIP-seq
MIRT1497709	hsa-miR-4484	CLIP-seq
MIRT1497710	hsa-miR-4516	CLIP-seq
MIRT1497711	hsa-miR-4531	CLIP-seq
MIRT1497712	hsa-miR-4638-3p	CLIP-seq
MIRT1497713	hsa-miR-4647	CLIP-seq
MIRT1497714	hsa-miR-4662b	CLIP-seq
MIRT1497715	hsa-miR-4677-5p	CLIP-seq
MIRT1497716	hsa-miR-4686	CLIP-seq
MIRT1497717	hsa-miR-4694-5p	CLIP-seq
MIRT1497718	hsa-miR-4722-5p	CLIP-seq
MIRT1497719	hsa-miR-4745-5p	CLIP-seq
MIRT1497720	hsa-miR-4752	CLIP-seq
MIRT1497721	hsa-miR-4760-3p	CLIP-seq
MIRT1497722	hsa-miR-4795-5p	CLIP-seq
MIRT1497723	hsa-miR-4797-3p	CLIP-seq
MIRT1497724	hsa-miR-515-3p	CLIP-seq
MIRT1497725	hsa-miR-519e	CLIP-seq
MIRT1497726	hsa-miR-548an	CLIP-seq
MIRT1497727	hsa-miR-548c-3p	CLIP-seq
MIRT1497728	hsa-miR-548q	CLIP-seq
MIRT1497729	hsa-miR-573	CLIP-seq
MIRT1497730	hsa-miR-607	CLIP-seq
MIRT1497731	hsa-miR-620	CLIP-seq
MIRT1497732	hsa-miR-635	CLIP-seq
MIRT1497733	hsa-miR-653	CLIP-seq
MIRT1497734	hsa-miR-7	CLIP-seq
MIRT1497735	hsa-miR-765	CLIP-seq
MIRT1497736	hsa-miR-875-3p	CLIP-seq
MIRT1497737	hsa-miR-944	CLIP-seq
MIRT1555630	hsa-miR-4716-3p	CLIP-seq
MIRT1555631	hsa-miR-4723-5p	CLIP-seq
MIRT1497686	hsa-miR-1286	CLIP-seq
MIRT2149918	hsa-miR-1324	CLIP-seq
MIRT2149919	hsa-miR-3130-3p	CLIP-seq
MIRT2149920	hsa-miR-3180-5p	CLIP-seq
MIRT2149921	hsa-miR-3614-5p	CLIP-seq
MIRT2149922	hsa-miR-3689a-3p	CLIP-seq
MIRT2149923	hsa-miR-3689c	CLIP-seq
MIRT2149924	hsa-miR-3919	CLIP-seq
MIRT2149925	hsa-miR-425	CLIP-seq
MIRT1497705	hsa-miR-4433	CLIP-seq
MIRT1497718	hsa-miR-4722-5p	CLIP-seq
MIRT2149926	hsa-miR-4737	CLIP-seq
MIRT2149927	hsa-miR-494	CLIP-seq
MIRT2149928	hsa-miR-520a-5p	CLIP-seq
MIRT2149929	hsa-miR-525-5p	CLIP-seq
MIRT2149930	hsa-miR-642b	CLIP-seq
MIRT2149931	hsa-miR-767-5p	CLIP-seq
MIRT2370050	hsa-miR-1236	CLIP-seq
MIRT2370051	hsa-miR-1269	CLIP-seq
MIRT2370052	hsa-miR-1269b	CLIP-seq
MIRT1497685	hsa-miR-1270	CLIP-seq
MIRT2370053	hsa-miR-1288	CLIP-seq
MIRT2370054	hsa-miR-2110	CLIP-seq
MIRT1497691	hsa-miR-296-3p	CLIP-seq
MIRT1497692	hsa-miR-3115	CLIP-seq
MIRT2370055	hsa-miR-3150a-3p	CLIP-seq
MIRT2370056	hsa-miR-3151	CLIP-seq
MIRT2370057	hsa-miR-3170	CLIP-seq
MIRT2149920	hsa-miR-3180-5p	CLIP-seq
MIRT2370058	hsa-miR-3616-3p	CLIP-seq
MIRT2149924	hsa-miR-3919	CLIP-seq
MIRT2149925	hsa-miR-425	CLIP-seq
MIRT2370059	hsa-miR-4291	CLIP-seq
MIRT1497705	hsa-miR-4433	CLIP-seq
MIRT1497706	hsa-miR-4434	CLIP-seq
MIRT2370060	hsa-miR-4447	CLIP-seq
MIRT2370061	hsa-miR-4472	CLIP-seq
MIRT1497708	hsa-miR-4481	CLIP-seq
MIRT2370062	hsa-miR-4515	CLIP-seq
MIRT1497710	hsa-miR-4516	CLIP-seq
MIRT1497711	hsa-miR-4531	CLIP-seq
MIRT2370063	hsa-miR-4740-5p	CLIP-seq
MIRT1497719	hsa-miR-4745-5p	CLIP-seq
MIRT1497720	hsa-miR-4752	CLIP-seq
MIRT2370064	hsa-miR-4778-3p	CLIP-seq
MIRT2370065	hsa-miR-491-5p	CLIP-seq
MIRT2149928	hsa-miR-520a-5p	CLIP-seq
MIRT2149929	hsa-miR-525-5p	CLIP-seq
MIRT2370066	hsa-miR-539	CLIP-seq
MIRT2370067	hsa-miR-545	CLIP-seq
MIRT1497731	hsa-miR-620	CLIP-seq
MIRT2149930	hsa-miR-642b	CLIP-seq
MIRT2370068	hsa-miR-760	CLIP-seq
MIRT1497735	hsa-miR-765	CLIP-seq
MIRT2397111	hsa-miR-486-3p	CLIP-seq
MIRT2466344	hsa-miR-3681	CLIP-seq
MIRT2149924	hsa-miR-3919	CLIP-seq
MIRT2466345	hsa-miR-4773	CLIP-seq
MIRT1497722	hsa-miR-4795-5p	CLIP-seq
MIRT2695391	hsa-miR-3180	CLIP-seq
MIRT2695392	hsa-miR-3180-3p	CLIP-seq
MIRT2695393	hsa-miR-3196	CLIP-seq
MIRT2695394	hsa-miR-342-5p	CLIP-seq
MIRT2695395	hsa-miR-3675-5p	CLIP-seq
MIRT2370060	hsa-miR-4447	CLIP-seq
MIRT2370061	hsa-miR-4472	CLIP-seq
MIRT2695396	hsa-miR-4488	CLIP-seq
MIRT2695397	hsa-miR-4651	CLIP-seq
MIRT2695398	hsa-miR-4664-5p	CLIP-seq
MIRT2695399	hsa-miR-4697-5p	CLIP-seq
MIRT2695400	hsa-miR-608	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004856	Function	D-xylulokinase activity	EXP	23179721
GO:0004856	Function	D-xylulokinase activity	IBA
GO:0004856	Function	D-xylulokinase activity	IDA	23179721
GO:0004856	Function	D-xylulokinase activity	IEA
GO:0004856	Function	D-xylulokinase activity	TAS	9763671
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0005975	Process	Carbohydrate metabolic process	TAS	9763671
GO:0005997	Process	Xylulose metabolic process	IBA
GO:0005997	Process	Xylulose metabolic process	IDA	23179721
GO:0005998	Process	Xylulose catabolic process	TAS	9763671
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	9763671
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019640	Process	D-glucuronate catabolic process to D-xylulose 5-phosphate	TAS
GO:0042732	Process	D-xylose metabolic process	IEA
GO:0046835	Process	Carbohydrate phosphorylation	IEA

Other IDs

• MIM: 604049
• HGNC: 12839
• e!Ensembl: ENSG00000093217

Protein

• UniProt ID: O75191
• Protein name: Xylulose kinase (Xylulokinase) (EC 2.7.1.17)
• Protein function: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.
• PDB: 4BC2 , 4BC3 , 4BC4 , 4BC5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00370	FGGY_N	125 → 287	FGGY family of carbohydrate kinases, N-terminal domain	Domain
  PF02782	FGGY_C	295 → 481	FGGY family of carbohydrate kinases, C-terminal domain	Domain

• Sequence:

  MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT
  VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR
  LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY
  QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH
  LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG
  TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK
  ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR
  IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG
  LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE

• Sequence length: 536

Pathways

KEGG Pathway	Reactome Pathway
Pentose and glucuronate interconversions	Formation of xylulose-5-phosphate
Metabolic pathways

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	29317602	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	26198764	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	30019117	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	33372590	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	25855559, 26352407	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension Pulmonary	Pulmonary hypertension	Pubtator	26352407	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	24122314		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	40148931	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CRYL1 2 shared pathwaysPentose and glucuronate interconversions, Formation of xylulose-5-phosphate Related via 2 shared pathways including Pentose and glucuronate interconversions, Formation of xylulose-5-phosphate. DCXR 2 shared pathwaysPentose and glucuronate interconversions, Formation of xylulose-5-phosphate Related via 2 shared pathways including Pentose and glucuronate interconversions, Formation of xylulose-5-phosphate. SORD 2 shared pathwaysPentose and glucuronate interconversions, Formation of xylulose-5-phosphate Related via 2 shared pathways including Pentose and glucuronate interconversions, Formation of xylulose-5-phosphate. AKR1A1 2 shared pathwaysPentose and glucuronate interconversions, Formation of xylulose-5-phosphate Related via 2 shared pathways including Pentose and glucuronate interconversions, Formation of xylulose-5-phosphate.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CRYL1	0	[]	2	["Pentose and glucuronate interconversions","Formation of xylulose-5-phosphate"]	0	[]
DCXR	0	[]	2	["Pentose and glucuronate interconversions","Formation of xylulose-5-phosphate"]	0	[]
SORD	0	[]	2	["Pentose and glucuronate interconversions","Formation of xylulose-5-phosphate"]	0	[]
AKR1A1	0	[]	2	["Pentose and glucuronate interconversions","Formation of xylulose-5-phosphate"]	0	[]

Diseases Linked via Similar Genes

Breast cancer Linked via 2 of 4 related genesCRYL1, AKR1A1 Obesity Linked via 2 of 4 related genesCRYL1, DCXR Prostatic neoplasms Linked via 2 of 4 related genesCRYL1, DCXR Astrocytoma Linked via 1 of 4 related genesCRYL1 Central nervous system cancer Linked via 1 of 4 related genesCRYL1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Breast cancer	2	["CRYL1","AKR1A1"]
Obesity	2	["CRYL1","DCXR"]
Prostatic neoplasms	2	["CRYL1","DCXR"]
Astrocytoma	1	["CRYL1"]
Central nervous system cancer	1	["CRYL1"]