Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51699
Gene name	VPS29 retromer complex component
Gene symbol	VPS29
Synonyms (NCBI Gene)	DC15DC7PEP11
Chromosome	12
Chromosome location	12q24.11
Summary	This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retrome

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miRTarBase ID	miRNA	Experiments	Reference
MIRT037751	hsa-miR-708-5p	CLASH	23622248
MIRT1486445	hsa-miR-142-5p	CLIP-seq
MIRT1486446	hsa-miR-3673	CLIP-seq
MIRT1486447	hsa-miR-3974	CLIP-seq
MIRT1486448	hsa-miR-4436b-5p	CLIP-seq
MIRT1486449	hsa-miR-4699-5p	CLIP-seq
MIRT1486450	hsa-miR-4709-3p	CLIP-seq
MIRT1486451	hsa-miR-4777-5p	CLIP-seq
MIRT1486452	hsa-miR-488	CLIP-seq
MIRT1486453	hsa-miR-513a-3p	CLIP-seq
MIRT1486454	hsa-miR-515-5p	CLIP-seq
MIRT1486455	hsa-miR-561	CLIP-seq
MIRT1486456	hsa-miR-624	CLIP-seq
MIRT1486457	hsa-miR-889	CLIP-seq
MIRT1486458	hsa-miR-4307	CLIP-seq
MIRT1486459	hsa-miR-4326	CLIP-seq
MIRT1486460	hsa-miR-659	CLIP-seq
MIRT2660379	hsa-miR-1183	CLIP-seq
MIRT2660380	hsa-miR-1305	CLIP-seq
MIRT2660381	hsa-miR-2113	CLIP-seq
MIRT2660382	hsa-miR-30a	CLIP-seq
MIRT2660383	hsa-miR-30b	CLIP-seq
MIRT2660384	hsa-miR-30c	CLIP-seq
MIRT2660385	hsa-miR-30d	CLIP-seq
MIRT2660386	hsa-miR-30e	CLIP-seq
MIRT2660387	hsa-miR-3138	CLIP-seq
MIRT2660388	hsa-miR-3607-3p	CLIP-seq
MIRT2660389	hsa-miR-376a	CLIP-seq
MIRT2660390	hsa-miR-376b	CLIP-seq
MIRT2660391	hsa-miR-3924	CLIP-seq
MIRT2660392	hsa-miR-421	CLIP-seq
MIRT2660393	hsa-miR-4275	CLIP-seq
MIRT2660394	hsa-miR-4318	CLIP-seq
MIRT2660395	hsa-miR-432	CLIP-seq
MIRT2660396	hsa-miR-4436a	CLIP-seq
MIRT2660397	hsa-miR-4453	CLIP-seq
MIRT2660398	hsa-miR-4474-3p	CLIP-seq
MIRT2660399	hsa-miR-4538	CLIP-seq
MIRT2660400	hsa-miR-4650-5p	CLIP-seq
MIRT2660401	hsa-miR-4666-3p	CLIP-seq
MIRT2660402	hsa-miR-4693-5p	CLIP-seq
MIRT2660403	hsa-miR-4700-3p	CLIP-seq
MIRT2660404	hsa-miR-4709-5p	CLIP-seq
MIRT2660405	hsa-miR-4752	CLIP-seq
MIRT2660406	hsa-miR-4800-5p	CLIP-seq
MIRT2660407	hsa-miR-5095	CLIP-seq
MIRT1486453	hsa-miR-513a-3p	CLIP-seq
MIRT2660408	hsa-miR-548aa	CLIP-seq
MIRT2660409	hsa-miR-548ac	CLIP-seq
MIRT2660410	hsa-miR-548c-3p	CLIP-seq
MIRT2660411	hsa-miR-548d-3p	CLIP-seq
MIRT2660412	hsa-miR-548z	CLIP-seq
MIRT1486456	hsa-miR-624	CLIP-seq
MIRT2660413	hsa-miR-760	CLIP-seq
MIRT2660414	hsa-miR-892a	CLIP-seq
MIRT2660380	hsa-miR-1305	CLIP-seq
MIRT2660381	hsa-miR-2113	CLIP-seq
MIRT2660392	hsa-miR-421	CLIP-seq
MIRT2660396	hsa-miR-4436a	CLIP-seq
MIRT2660398	hsa-miR-4474-3p	CLIP-seq
MIRT2660400	hsa-miR-4650-5p	CLIP-seq
MIRT2660401	hsa-miR-4666-3p	CLIP-seq
MIRT2660403	hsa-miR-4700-3p	CLIP-seq
MIRT2660404	hsa-miR-4709-5p	CLIP-seq
MIRT2660408	hsa-miR-548aa	CLIP-seq
MIRT2660409	hsa-miR-548ac	CLIP-seq
MIRT2660410	hsa-miR-548c-3p	CLIP-seq
MIRT2660411	hsa-miR-548d-3p	CLIP-seq
MIRT2660412	hsa-miR-548z	CLIP-seq
MIRT2660413	hsa-miR-760	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11102511, 16732284, 17891154, 19619496, 20923837, 24152121, 24344282, 24603492, 24747528, 24980502, 25416956, 25502805, 26496610, 27385586, 28514442, 28892079, 31515488, 32296183, 32814053, 33961781, 35271311, 37172566
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005770	Component	Late endosome	IEA
GO:0005829	Component	Cytosol	IDA	11102511
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	IBA
GO:0010008	Component	Endosome membrane	IEA
GO:0010506	Process	Regulation of autophagy	IMP	24603492
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0030904	Component	Retromer complex	IBA
GO:0030904	Component	Retromer complex	IDA	11102511, 28892079
GO:0030904	Component	Retromer complex	IEA
GO:0030906	Component	Retromer, cargo-selective complex	IDA	27385586
GO:0030906	Component	Retromer, cargo-selective complex	NAS	26220253
GO:0032456	Process	Endocytic recycling	IMP	28892079
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IEA
GO:0042147	Process	Retrograde transport, endosome to Golgi	NAS	26220253
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
606932	14340	ENSG00000111237

Q9UBQ0

Protein name

Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29)

Protein function

Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:39587083, PubMed:38062209, PubMed

PDB

1W24 , 2R17 , 5GTU , 5OSH , 5OSI , 5WYH , 6XS5 , 6XS7 , 6XS9 , 6XSA , 7BLN , 8ESE , 8P0V , 8P0X , 8R02 , 8R0J , 8RKS , 8SYM , 8SYN , 8SYO , 9AU7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12850	Metallophos_2	1 → 158	Calcineurin-like phosphoesterase superfamily domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.

Sequence

MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVR
GDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFE
AFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYK
KP

Sequence length

182

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocytosis	WNT ligand biogenesis and trafficking

VPS29 (VPS29 retromer complex component)

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