VCY (variable charge Y-linked)

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Gene Gene information from NCBI Gene database.
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Entrez ID 9084
Gene name Variable charge Y-linked
Gene symbol VCY
Synonyms (NCBI Gene)
BPY1VCY1VCY1A
Chromosome Y
Chromosome location Yq11.221
Summary The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequ
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32814053
GO:0007420 Process Brain development IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
400012 12668 ENSG00000129864
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
SPERMATOGENIC FAILURE, NONOBSTRUCTIVE, Y-LINKED — CTD —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SPERMATOGENIC FAILURE, Y-LINKED, 2 — ClinVar, HPO
ClinVar, HPO 		—
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Azoospermia Azoospermia HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 29453317 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Intellectual Disability Mental retardation BEFREE 15888481
★★★★★
★☆☆☆☆
Found in Text Mining only
Mental Retardation Mental retardation BEFREE 15888481
★★★★★
★☆☆☆☆
Found in Text Mining only
Spermatogenic Failure, Nonobstructive, Y-Linked Nonobstructive Spermatogenic Failure, Y-Linked CTD_human_DG
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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BPY2 1 shared diseaseSpermatogenic failure, y-linked 3 shared evidence sourcesCTD (Spermatogenic failure, y-linked), ClinVar (Spermatogenic failure, y-linked), HPO (Spermatogenic failure, y-linked) Related via 1 shared disease including Spermatogenic failure, y-linked — evidence mostly CTD. CDY1 1 shared diseaseSpermatogenic failure, y-linked 3 shared evidence sourcesCTD (Spermatogenic failure, y-linked), ClinVar (Spermatogenic failure, y-linked), HPO (Spermatogenic failure, y-linked) Related via 1 shared disease including Spermatogenic failure, y-linked — evidence mostly CTD. CDY2A 1 shared diseaseSpermatogenic failure, y-linked 3 shared evidence sourcesCTD (Spermatogenic failure, y-linked), ClinVar (Spermatogenic failure, y-linked), HPO (Spermatogenic failure, y-linked) Related via 1 shared disease including Spermatogenic failure, y-linked — evidence mostly CTD. HSFY1 1 shared diseaseSpermatogenic failure, y-linked 3 shared evidence sourcesCTD (Spermatogenic failure, y-linked), ClinVar (Spermatogenic failure, y-linked), HPO (Spermatogenic failure, y-linked) Related via 1 shared disease including Spermatogenic failure, y-linked — evidence mostly CTD. DAZ1 1 shared diseaseSpermatogenic failure, y-linked 3 shared evidence sourcesCTD (Spermatogenic failure, y-linked), ClinVar (Spermatogenic failure, y-linked), HPO (Spermatogenic failure, y-linked) Related via 1 shared disease including Spermatogenic failure, y-linked — evidence mostly CTD.
Chromosome y microdeletion syndrome Linked via 1 of 5 related genesDAZ1