This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multip
miRNAmiRNA information provided by mirtarbase database.
["Activation of IRF3\/IRF7 mediated by TBK1\/IKK epsilon","Caspase activation via Death Receptors in the presence of ligand","Toll Like Receptor 4 (TLR4) Cascade","MyD88-independent TLR4 cascade ","TRIF-mediated programmed cell death","IKK complex recruitment mediated by RIP1","TRAF6-mediated induction of TAK1 complex within TLR4 complex","IRAK2 mediated activation of TAK1 complex upon TLR7\/8 or 9 stimulation"]
["Activation of IRF3\/IRF7 mediated by TBK1\/IKK epsilon","Caspase activation via Death Receptors in the presence of ligand","Toll Like Receptor 4 (TLR4) Cascade","MyD88-independent TLR4 cascade ","TRIF-mediated programmed cell death","IKK complex recruitment mediated by RIP1","TRAF6-mediated induction of TAK1 complex within TLR4 complex","IRAK2 mediated activation of TAK1 complex upon TLR7\/8 or 9 stimulation"]
["Activation of IRF3\/IRF7 mediated by TBK1\/IKK epsilon","MyD88-independent TLR4 cascade ","IKK complex recruitment mediated by RIP1","TRAF6-mediated induction of TAK1 complex within TLR4 complex"]
["Activation of IRF3\/IRF7 mediated by TBK1\/IKK epsilon","Caspase activation via Death Receptors in the presence of ligand","Toll Like Receptor 4 (TLR4) Cascade","MyD88-independent TLR4 cascade ","TRIF-mediated programmed cell death","IKK complex recruitment mediated by RIP1","TRAF6-mediated induction of TAK1 complex within TLR4 complex","IRAK2 mediated activation of TAK1 complex upon TLR7\/8 or 9 stimulation"]
["Activation of IRF3\/IRF7 mediated by TBK1\/IKK epsilon","Caspase activation via Death Receptors in the presence of ligand","MyD88-independent TLR4 cascade ","TRIF-mediated programmed cell death","IKK complex recruitment mediated by RIP1","TRAF6-mediated induction of TAK1 complex within TLR4 complex","IRAK2 mediated activation of TAK1 complex upon TLR7\/8 or 9 stimulation"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to TMED7-TICAM2 (see Related Genes above), that are NOT already directly curated for TMED7-TICAM2 itself -- a lead worth checking, not a confirmed association.