Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	84321
Gene name	THO complex subunit 3
Gene symbol	THOC3
Synonyms (NCBI Gene)	THO3hTREX45
Chromosome	5
Chromosome location	5q35.2
Summary	This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited t

153 Show/Hide all (153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050030	hsa-miR-27a-3p	CLASH	23622248
MIRT047243	hsa-miR-181b-5p	CLASH	23622248
MIRT046211	hsa-miR-27b-3p	CLASH	23622248
MIRT1423432	hsa-miR-105	CLIP-seq
MIRT1423433	hsa-miR-1276	CLIP-seq
MIRT1423434	hsa-miR-186	CLIP-seq
MIRT1423435	hsa-miR-2467-3p	CLIP-seq
MIRT1423436	hsa-miR-2909	CLIP-seq
MIRT1423437	hsa-miR-3064-3p	CLIP-seq
MIRT1423438	hsa-miR-3144-3p	CLIP-seq
MIRT1423439	hsa-miR-3158-5p	CLIP-seq
MIRT1423440	hsa-miR-3678-3p	CLIP-seq
MIRT1423441	hsa-miR-3688-3p	CLIP-seq
MIRT1423442	hsa-miR-3691-3p	CLIP-seq
MIRT1423443	hsa-miR-374c	CLIP-seq
MIRT1423444	hsa-miR-382	CLIP-seq
MIRT1423445	hsa-miR-3925-5p	CLIP-seq
MIRT1423446	hsa-miR-3978	CLIP-seq
MIRT1423447	hsa-miR-4293	CLIP-seq
MIRT1423448	hsa-miR-4418	CLIP-seq
MIRT1423449	hsa-miR-4424	CLIP-seq
MIRT1423450	hsa-miR-4488	CLIP-seq
MIRT1423451	hsa-miR-4672	CLIP-seq
MIRT1423452	hsa-miR-4697-5p	CLIP-seq
MIRT1423453	hsa-miR-4731-5p	CLIP-seq
MIRT1423454	hsa-miR-4764-3p	CLIP-seq
MIRT1423455	hsa-miR-4773	CLIP-seq
MIRT1423456	hsa-miR-509-3-5p	CLIP-seq
MIRT1423457	hsa-miR-509-5p	CLIP-seq
MIRT1423458	hsa-miR-520d-5p	CLIP-seq
MIRT1423459	hsa-miR-524-5p	CLIP-seq
MIRT1423460	hsa-miR-548ae	CLIP-seq
MIRT1423461	hsa-miR-548aj	CLIP-seq
MIRT1423462	hsa-miR-548am	CLIP-seq
MIRT1423463	hsa-miR-548x	CLIP-seq
MIRT1423464	hsa-miR-610	CLIP-seq
MIRT1423465	hsa-miR-637	CLIP-seq
MIRT1423466	hsa-miR-655	CLIP-seq
MIRT1423467	hsa-miR-938	CLIP-seq
MIRT2126868	hsa-miR-1470	CLIP-seq
MIRT1423435	hsa-miR-2467-3p	CLIP-seq
MIRT1423439	hsa-miR-3158-5p	CLIP-seq
MIRT1423440	hsa-miR-3678-3p	CLIP-seq
MIRT1423442	hsa-miR-3691-3p	CLIP-seq
MIRT1423444	hsa-miR-382	CLIP-seq
MIRT1423445	hsa-miR-3925-5p	CLIP-seq
MIRT1423448	hsa-miR-4418	CLIP-seq
MIRT2126869	hsa-miR-4469	CLIP-seq
MIRT2126870	hsa-miR-4667-3p	CLIP-seq
MIRT1423455	hsa-miR-4773	CLIP-seq
MIRT1423456	hsa-miR-509-3-5p	CLIP-seq
MIRT1423457	hsa-miR-509-5p	CLIP-seq
MIRT1423460	hsa-miR-548ae	CLIP-seq
MIRT1423461	hsa-miR-548aj	CLIP-seq
MIRT1423462	hsa-miR-548am	CLIP-seq
MIRT1423463	hsa-miR-548x	CLIP-seq
MIRT1423467	hsa-miR-938	CLIP-seq
MIRT1423432	hsa-miR-105	CLIP-seq
MIRT2348683	hsa-miR-1252	CLIP-seq
MIRT2348684	hsa-miR-1253	CLIP-seq
MIRT2348685	hsa-miR-1912	CLIP-seq
MIRT2348686	hsa-miR-198	CLIP-seq
MIRT1423435	hsa-miR-2467-3p	CLIP-seq
MIRT1423437	hsa-miR-3064-3p	CLIP-seq
MIRT1423439	hsa-miR-3158-5p	CLIP-seq
MIRT2348687	hsa-miR-3162-3p	CLIP-seq
MIRT2348688	hsa-miR-3183	CLIP-seq
MIRT2348689	hsa-miR-331-5p	CLIP-seq
MIRT1423440	hsa-miR-3678-3p	CLIP-seq
MIRT1423442	hsa-miR-3691-3p	CLIP-seq
MIRT1423444	hsa-miR-382	CLIP-seq
MIRT2348690	hsa-miR-3919	CLIP-seq
MIRT2348691	hsa-miR-4287	CLIP-seq
MIRT1423448	hsa-miR-4418	CLIP-seq
MIRT1423449	hsa-miR-4424	CLIP-seq
MIRT2348692	hsa-miR-4459	CLIP-seq
MIRT2126869	hsa-miR-4469	CLIP-seq
MIRT2348693	hsa-miR-4678	CLIP-seq
MIRT2348694	hsa-miR-4685-3p	CLIP-seq
MIRT2348695	hsa-miR-4723-3p	CLIP-seq
MIRT1423453	hsa-miR-4731-5p	CLIP-seq
MIRT1423454	hsa-miR-4764-3p	CLIP-seq
MIRT2348696	hsa-miR-501-3p	CLIP-seq
MIRT2348697	hsa-miR-502-3p	CLIP-seq
MIRT1423456	hsa-miR-509-3-5p	CLIP-seq
MIRT1423457	hsa-miR-509-5p	CLIP-seq
MIRT2348698	hsa-miR-520a-5p	CLIP-seq
MIRT2348699	hsa-miR-525-5p	CLIP-seq
MIRT2348700	hsa-miR-541	CLIP-seq
MIRT2348701	hsa-miR-615-5p	CLIP-seq
MIRT2348702	hsa-miR-624	CLIP-seq
MIRT2348703	hsa-miR-654-5p	CLIP-seq
MIRT2348704	hsa-miR-7	CLIP-seq
MIRT2348683	hsa-miR-1252	CLIP-seq
MIRT2348684	hsa-miR-1253	CLIP-seq
MIRT1423434	hsa-miR-186	CLIP-seq
MIRT2348685	hsa-miR-1912	CLIP-seq
MIRT2348686	hsa-miR-198	CLIP-seq
MIRT2641870	hsa-miR-203	CLIP-seq
MIRT1423435	hsa-miR-2467-3p	CLIP-seq
MIRT1423436	hsa-miR-2909	CLIP-seq
MIRT1423437	hsa-miR-3064-3p	CLIP-seq
MIRT1423439	hsa-miR-3158-5p	CLIP-seq
MIRT2641871	hsa-miR-330-3p	CLIP-seq
MIRT1423440	hsa-miR-3678-3p	CLIP-seq
MIRT1423441	hsa-miR-3688-3p	CLIP-seq
MIRT2348690	hsa-miR-3919	CLIP-seq
MIRT1423445	hsa-miR-3925-5p	CLIP-seq
MIRT1423446	hsa-miR-3978	CLIP-seq
MIRT1423447	hsa-miR-4293	CLIP-seq
MIRT1423448	hsa-miR-4418	CLIP-seq
MIRT1423449	hsa-miR-4424	CLIP-seq
MIRT2348692	hsa-miR-4459	CLIP-seq
MIRT1423450	hsa-miR-4488	CLIP-seq
MIRT1423452	hsa-miR-4697-5p	CLIP-seq
MIRT1423453	hsa-miR-4731-5p	CLIP-seq
MIRT1423454	hsa-miR-4764-3p	CLIP-seq
MIRT1423455	hsa-miR-4773	CLIP-seq
MIRT2348696	hsa-miR-501-3p	CLIP-seq
MIRT2348697	hsa-miR-502-3p	CLIP-seq
MIRT1423456	hsa-miR-509-3-5p	CLIP-seq
MIRT1423457	hsa-miR-509-5p	CLIP-seq
MIRT2348698	hsa-miR-520a-5p	CLIP-seq
MIRT1423458	hsa-miR-520d-5p	CLIP-seq
MIRT1423459	hsa-miR-524-5p	CLIP-seq
MIRT2348699	hsa-miR-525-5p	CLIP-seq
MIRT2348700	hsa-miR-541	CLIP-seq
MIRT2641872	hsa-miR-548p	CLIP-seq
MIRT2348702	hsa-miR-624	CLIP-seq
MIRT1423465	hsa-miR-637	CLIP-seq
MIRT2348703	hsa-miR-654-5p	CLIP-seq
MIRT1423434	hsa-miR-186	CLIP-seq
MIRT2641870	hsa-miR-203	CLIP-seq
MIRT1423435	hsa-miR-2467-3p	CLIP-seq
MIRT1423436	hsa-miR-2909	CLIP-seq
MIRT1423439	hsa-miR-3158-5p	CLIP-seq
MIRT2641871	hsa-miR-330-3p	CLIP-seq
MIRT1423440	hsa-miR-3678-3p	CLIP-seq
MIRT1423445	hsa-miR-3925-5p	CLIP-seq
MIRT1423447	hsa-miR-4293	CLIP-seq
MIRT1423448	hsa-miR-4418	CLIP-seq
MIRT1423449	hsa-miR-4424	CLIP-seq
MIRT1423450	hsa-miR-4488	CLIP-seq
MIRT1423452	hsa-miR-4697-5p	CLIP-seq
MIRT1423453	hsa-miR-4731-5p	CLIP-seq
MIRT1423454	hsa-miR-4764-3p	CLIP-seq
MIRT1423455	hsa-miR-4773	CLIP-seq
MIRT1423456	hsa-miR-509-3-5p	CLIP-seq
MIRT1423457	hsa-miR-509-5p	CLIP-seq
MIRT1423458	hsa-miR-520d-5p	CLIP-seq
MIRT1423459	hsa-miR-524-5p	CLIP-seq
MIRT2641872	hsa-miR-548p	CLIP-seq
MIRT1423465	hsa-miR-637	CLIP-seq

14 Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000346	Component	Transcription export complex	IDA	15833825, 15998806
GO:0000445	Component	THO complex part of transcription export complex	IBA
GO:0000445	Component	THO complex part of transcription export complex	IDA	23222130
GO:0000781	Component	Chromosome, telomeric region	IDA	24270157
GO:0003723	Function	RNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006406	Process	MRNA export from nucleus	IBA
GO:0006406	Process	MRNA export from nucleus	IDA	17190602
GO:0006406	Process	MRNA export from nucleus	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0051028	Process	MRNA transport	IEA

MIM	HGNC	e!Ensembl
606929	19072	ENSG00000051596

Q96J01

Protein name

THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)

Protein function

Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:159988

PDB

7APK , 7ZNK , 7ZNL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	89 → 128	WD domain, G-beta repeat	Repeat
PF00400	WD40	40 → 82	WD domain, G-beta repeat	Repeat
PF08662	eIF2A	131 → 246	Eukaryotic translation initiation factor eIF2A	Family
PF12894	ANAPC4_WD40	262 → 316	Anaphase-promoting complex subunit 4 WD40 domain	Repeat

Sequence

MAVPAAAMGPSALGQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHS
VAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASG
DKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQ
FKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFA
TGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDK
LWEVQCESPTFTVAWHPKRPLLAFACDDKDGKYDSSREAGTVKLFGLPNDS

Sequence length

351

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Nucleocytoplasmic transport	Transport of Mature mRNA derived from an Intron-Containing Transcript
Spliceosome	mRNA 3'-end processing
	RNA Polymerase II Transcription Termination

THOC3 (THO complex subunit 3)

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